Secondary bone/soft tissue sarcoma in childhood cancer survivors: a nationwide hospital-based case-series study in Japan

2018 ◽  
Vol 48 (9) ◽  
pp. 806-814 ◽  
Author(s):  
Yasushi Ishida ◽  
Miho Maeda ◽  
Souichi Adachi ◽  
Takeshi Rikiishi ◽  
Maho Sato ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Cancer Survivors ◽  
Childhood Cancer ◽  
Case Series ◽  
Childhood Cancer Survivors ◽  
Case Series Study ◽  
Series Study

Anthracycline-induced cardiotoxicity in patients with paediatric bone sarcoma and soft tissue sarcoma

2017 ◽  
Vol 27 (9) ◽  
pp. 1815-1822 ◽  
Author(s):  
Ilaria Bini ◽  
Sebastian D. Asaftei ◽  
Chiara Riggi ◽  
Elisa Tirtei ◽  
Rosaria Manicone ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Heart Transplantation ◽  
Cancer Survivors ◽  
Childhood Cancer ◽  
Cardiac Toxicity ◽  
Childhood Cancer Survivors ◽  
Anthracycline Cardiotoxicity ◽  
Anthracycline Dose

AbstractObjectivesAnthracycline cardiotoxicity is an important side-effect in long-term childhood cancer survivors. We evaluated the incidence of and factors associated with anthracycline cardiotoxicity in a population of patients diagnosed with bone or soft tissue sarcoma.Materials and methodsWe retrospectively enrolled patients diagnosed with bone or soft tissue sarcoma, from 1995 to 2011, treated with anthracycline chemotherapy at our Centre and with a follow-up echocardiography carried out ⩾3 years from cardiotoxic therapy completion. Cardiac toxicity was graded using Common Terminology Criteria for Adverse Events version 4.0.ResultsA total of 82 patients were eligible. The median age at treatment was 11.9 years (1.44–18). We evaluated the median cumulative anthracycline dose, age at treatment, sex, thoracic radiotherapy, hematopoietic stem cell transplantation, and high-dose cyclophosphamide treatment as possible risk factors for cardiotoxicity. The median cumulative anthracycline dose was 390.75 mg/m2(80–580). Of the 82 patients, 12 (14.6%) developed cardiotoxicity with grade ⩾2 ejection fraction decline: four patients were asymptomatic and did not receive any treatment; six patients were treated with pharmacological heart failure therapy; one patient with severe cardiomyopathy underwent heart transplantation and did not need any further treatment; and one patient died while waiting for heart transplantation. The median time at cardiac toxicity, from the end of anthracycline frontline chemotherapy, was 4.2 years (0.05–9.6). Cumulative anthracycline dose ⩾300 mg/m2(p 0.04) was the only risk factor for cardiotoxicity on statistical analyses.ConclusionsIn our population, the cumulative incidence of cardiotoxicity is comparable to rates in the literature. This underlines the need for primary prevention and lifelong cardiac toxicity surveillance programmes in long-term childhood cancer survivors.

Neuromuscular dysfunction and associated health/socioeconomic outcomes: A report from the Childhood Cancer Survivor Study (CCSS).

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. 10546-10546
Author(s):  
Rozalyn L Rodwin ◽  
Yan Chen ◽  
Yutaka Yasui ◽  
Wendy M. Leisenring ◽  
Todd M. Gibson ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Cancer Survivors ◽  
Childhood Cancer ◽  
Cumulative Incidence ◽  
Childhood Cancer Survivors ◽  
Soft Tissue Tumors ◽  
Motor Dysfunction ◽  
Vinca Alkaloids ◽  
Socioeconomic Outcomes ◽  
Neuromuscular Dysfunction

10546 Background: Childhood cancer survivors are at risk for neuromuscular dysfunction. We estimated the prevalence and cumulative incidence of neuromuscular dysfunction in a cohort of childhood cancer survivors and examined associations with treatment exposures and health/socioeconomic outcomes. Methods: CCSS participants ≥5 years from cancer diagnosed between 1970-1999 (n = 25,583, 46.5% female, median [range] age 54.4 [15.1-57.6] years) and siblings (n = 5,044, 52.3% female, median [range] age 54.1 [32.5-57.0] years) were included. Neuromuscular dysfunction was identified by self-report of 1) motor dysfunction: impaired balance, tremor, or extremity weakness; 2) sensory dysfunction: impaired touch sensation. Multivariable analyses examined predictors of dysfunction by diagnosis. Results: Cumulative incidence of neuromuscular dysfunction was elevated at 20 years from diagnosis in survivors (24.3%, 95% CI 23.8-24.8; motor 18.2%, sensory 13.5%) versus siblings (8.9%, 95% CI 8.1-9.7). In survivors five years from diagnosis, motor dysfunction was associated with exposure to cytarabine (OR = 1.39, 95% CI 1.10-1.77) and spinal radiation (OR = 2.11, 95% CI 1.31-3.41) in acute lymphoblastic leukemia/non-hodgkin lymphoma (ALL/NHL), vinca alkaloids (OR 1.29, 95% CI 1.03-1.60) and brain radiation (OR = 1.58, 95% CI 1.35-1.85) in central nervous system tumors, and cytarabine (OR = 3.73, 95% CI 1.62-8.57) and non-brain/spine radiation (OR = 1.84, 95% CI 1.42-2.40) in bone/soft tissue tumors. Sensory dysfunction was associated with exposure to vinca alkaloids (OR = 3.45, 95% CI 1.06-11.22) in ALL/NHL, and platinum agents (OR = 1.31, 95% CI 1.03-1.67) and spinal radiation (OR = 3.71, 95% CI 1.24-11.11) in bone/soft tissue tumors. Survivors with neuromuscular dysfunction were at increased risk for adverse health/socioeconomic outcomes (Table). Conclusions: Neuromuscular dysfunction is a prevalent morbidity in childhood cancer survivors, associated with specific therapies within a particular diagnosis. Interventions are needed to identify and improve neuromuscular dysfunction given its association with adverse health/socioeconomic outcomes. [Table: see text]

scholarly journals Necrotizing soft-tissue infections in pediatric intensive care: a prospective multicenter case-series study

Critical Care ◽  
2021 ◽  
Vol 25 (1) ◽  
Author(s):  
Stéphane Dauger ◽  
◽  
Renaud Blondé ◽  
Olivier Brissaud ◽  
Marie-Odile Marcoux ◽  
...  
Keyword(s):  
Intensive Care ◽  
Soft Tissue ◽  
Case Series ◽  
Pediatric Intensive Care ◽  
Soft Tissue Infections ◽  
Case Series Study ◽  
Necrotizing Soft Tissue Infections ◽  
Series Study

Schwannoma Formation in Childhood Cancer Survivors Exposed to Total Body Irradiation: Case Series

2019 ◽  
Vol 8 (4) ◽  
pp. 477-480
Author(s):  
Emily Anderson ◽  
Nadine Linendoll ◽  
Carl B. Heilman ◽  
Ron I. Riesenburger ◽  
Miriam A. O'Leary ◽  
...  
Keyword(s):  
Cancer Survivors ◽  
Childhood Cancer ◽  
Total Body Irradiation ◽  
Case Series ◽  
Childhood Cancer Survivors ◽  
Total Body

scholarly journals Aesthetics outcome of immediately restored single implants placed in extraction sockets in the anterior maxilla: A case series study

2020 ◽  
Vol 14 (1) ◽  
pp. 48-53
Author(s):  
Amin Saedi Germi ◽  
Vadoud Ghasemi Barghi ◽  
Karim Jafari ◽  
Rahman Nemati ◽  
Saeed Yeganzad
Keyword(s):  
Soft Tissue ◽  
Case Series ◽  
T Test ◽  
Facial Soft Tissue ◽  
Anterior Maxilla ◽  
Case Series Study ◽  
Significant Difference ◽  
The Status ◽  
The Aesthetic ◽  
Series Study

Background . Immediate single implant placement and restoration (IIR) is recognized as a novel method and is the main request of many patients. This study was designed to evaluate the aesthetic outcomes of immediately restored single implants placed in extraction sockets in theanterior maxilla. Methods. In this case series study, 18 patients were selected from two private clinics after placing a single-tooth implant in the anterior maxilla. Immediate provisional crowns were delivered on the following day or at most 48 hours later, and guidelines were provided. The Pink Esthetic Score (PES) questionnaire was used at 6- and 12-month follow-ups to assess aesthetic outcomes. Data were analyzed with single t-test and dependent t-test. Results. In general, the results showed that the status of the mesial papilla, distal papilla, curve of the facial soft tissue line, level of the facial peri-implant mucosa and root convexity soft tissue in IIR method were optimal (P<0.05), with total PES means of 9.44±0.783 and 8.58±1.003 after 6 and 12 months, respectively. Also, the results showed a significant difference in PES between the 6-month and 12-month intervals (P<0.05). Conclusion. IIR is a viable method that resulted in optimal aesthetic outcomes based on PES in the short term. Considering its confirmation in this study and previous studies, it is recommended that dentists apply this method.

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