The Effect of Severe Protein Deficiency on Serum Zinc Concentration of Mice Fed a Requirement Level or a Very High Level of Dietary Zinc

Assessing the prevalence and severity of zinc deficiency in populations is critical to determine the need for and appropriate targeting of zinc intervention programs and to assess their effectiveness for improving the health and well-being of high-risk populations. However, there is very little information on the zinc status of populations worldwide due to the lack of consensus on appropriate biochemical indicators of zinc status. The objective of this review was to evaluate the use of serum zinc concentration as an indicator of population zinc status. We have reviewed the response of serum zinc concentration to dietary zinc restriction and zinc supplementation. In addition, we completed pooled analyses of nine zinc intervention trials in young children to assess the relations between serum zinc concentration of individuals before treatment and their responses to zinc supplementation. Also, in updated combined analyses of previously published data, we investigated the relation between the mean initial serum zinc concentration of a study population and their mean growth responses to zinc supplementation in randomized intervention trials among children. The results from depletion/repletion studies indicate that serum zinc concentrations respond appreciably to severe dietary zinc restriction, although there is considerable interindividual variation in these responses. There is also clear evidence that both individual and population mean serum zinc concentrations increase consistently during zinc supplementation, regardless of the initial level of serum zinc concentration. By contrast, an individual's serum zinc concentration does not reliably predict that person's response to zinc supplementation. Serum zinc concentration can be considered a useful biomarker of a population's risk of zinc deficiency and response to zinc interventions, although it may not be a reliable indicator of individual zinc status.

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A positive association between maternal serum zinc concentration and birth weight

American Journal of Clinical Nutrition ◽

10.1093/ajcn/51.4.678 ◽

1990 ◽

Vol 51 (4) ◽

pp. 678-684 ◽

Cited By ~ 66

Author(s):

Y H Neggers ◽

G R Cutter ◽

R T Acton ◽

J O Alvarez ◽

J L Bonner ◽

...

Keyword(s):

Birth Weight ◽

Zinc Concentration ◽

Serum Zinc ◽

Positive Association ◽

Maternal Serum ◽

Serum Zinc Concentration

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Subnormal Serum Zinc Concentration in a Patient with Zinc Fever

Occupational Medicine ◽

10.1093/occmed/33.4.187 ◽

1983 ◽

Vol 33 (4) ◽

pp. 187-189 ◽

Cited By ~ 2

Author(s):

RUNE J. ULVIK

Keyword(s):

Zinc Concentration ◽

Serum Zinc ◽

Serum Zinc Concentration

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Reduced Serum Zinc Concentration During Pregnancy

Obstetrics and Gynecology ◽

10.1097/00006250-198309000-00010 ◽

1983 ◽

Vol 62 (3) ◽

pp. 313-318 ◽

Cited By ~ 53

Author(s):

C. A. SWANSON ◽

J. C. KING

Keyword(s):

Zinc Concentration ◽

Serum Zinc ◽

Serum Zinc Concentration

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A prospective study of serum zinc concentration in children with celiac disease

The Journal of Pediatrics ◽

10.1016/s0022-3476(83)80248-0 ◽

1983 ◽

Vol 102 (5) ◽

pp. 734-736 ◽

Cited By ~ 15

Author(s):

Yehezkel Naveh ◽

Abraham Lightman ◽

Oren Zinder

Keyword(s):

Celiac Disease ◽

Prospective Study ◽

Zinc Concentration ◽

Serum Zinc ◽

Serum Zinc Concentration ◽

A Prospective Study

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Serum Zinc Level in Pre-eclamptic Pregnancies: Association with Clinical Complication

Bangladesh Medical Journal ◽

10.3329/bmj.v39i1.6226 ◽

1970 ◽

Vol 39 (1) ◽

pp. 7-10

Author(s):

Touhida Ahsan ◽

Razia Sultana Begum ◽

Sheikh Naznul Islam

Keyword(s):

Blood Pressure ◽

Diastolic Blood Pressure ◽

Zinc Concentration ◽

Serum Zinc ◽

Zinc Level ◽

Contributory Factor ◽

Serum Zinc Concentration ◽

Correlative Analysis ◽

Blood Pressures ◽

In Pregnancy

Pre-eclampsia is one of the fatal complications in pregnancy. Zinc plays an important role in the course and eventual outcome of human pregnancy, and is essential for normal embryogenesis and fetal growth. Zinc deficiency in pregnancy is thought to be associated with pre-eclampsia. The aim of this study was, therefore, to investigate the scum zinc level in pre-eclampsia and to examine its association (if any) with pre-eclampsia. A case control study was done among 45 pre-eclamptic and 35 normotensive pregnants at their third trimester. Serum zinc concentration was determined by Atomic Absorption Flame Spectrophotometric method. Correlative analysis was made to find any correlation, of serum zinc with blood Pressure. Results showed identical Maternal and gestational age, and different gravida distribution for the patients and controls, and significantly (P<0.005) higher blood pressures (systolic and diastolic) for pre-eclampsia. Serum zinc concentration were estimated 0.65±0.09mg/L in pre-eclamsia and 0.60±0.08mg/L in pregnant controls, difference of which was insignificant (p=0.284). Correlative analysis wowed that there was a linear correlation between serum level and diastolic blood pressure, but it was found to be insignificant (r=0.158, p=0.330). It was suggested that changes in zinc status may not be an etiological or contributory factor in pre-eclamsia. Key words: Serum zinc; pre-eclampsia; diastolic blood pressure DOI: 10.3329/bmj.v39i1.6226 Bangladesh Medical Journal 2010; 39(1): 7-10

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