Lower Serum Zinc Concentration Despite Higher Dietary Zinc Intake in Athletes: A Systematic Review and Meta-analysis

Background Soil-transmitted helminth (STH) infection can cause malnutrition and vice versa, and decrease serum zinc concentrations. No previous studies were found on the effect of STH treatment on serum zinc concentrations in elementary school children. The objective of this study was to evalaute the effect of STH treatment on serum zinc concentration in elementary school children in Jakarta. Methods A pre-experimental study (one group pre and post) was conducted on 3rd - 5th grade students in one elementary school in North Jakarta. FLOTAC examination was used to determine infection status and STH intensity, while serum zinc concentrations were measured by atomic absorption spectrometry. All children were given albendazole 400 mg for three consecutive days. Stool and blood samples were collected before and three weeks after treatment with albendazole. A paired t test was used to analyze the data. Results The STH prevalence was 63.4%; these were mainly Ascaris lumbricoides and Trichuris trichiura infections. Before treatment, children infected with A.lumbricoides and T.trichiura had significantly higher serum zinc concentrations (p=0.028; p=0.014). After treatment, children with A.lumbricoides had significantly lower serum zinc concentrations (p=0.039), while children with T.trichiura had slightly lower serum zinc concentrations (p=0.659) than before treatment. Conclusions Albendazole treatment produces lower serum zinc concentration in elementary school children with A.lumbricoides infections. A profound understanding of the interaction between helminth infections and zinc may assist in guiding integrated and sustainable intervention strategies among affected children throughout the world.

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Comparative study of serum zinc concentrations in benign and malignant prostate disease: A Systematic Review and Meta-Analysis

Scientific Reports ◽

10.1038/srep25778 ◽

2016 ◽

Vol 6 (1) ◽

Cited By ~ 13

Author(s):

Jiang Zhao ◽

Qingjian Wu ◽

Xiaoyan Hu ◽

Xingyou Dong ◽

Liang Wang ◽

...

Keyword(s):

Zinc Concentration ◽

Meta Analysis ◽

Serum Zinc ◽

Cochrane Library ◽

Prostatic Disease ◽

Serum Zinc Concentration ◽

Prostate Disease ◽

Zinc Concentrations ◽

The Relationship ◽

Normal Controls

Abstract Many studies have investigated the relationship between serum zinc concentration and prostatic disease, but have shown inconsistent results. Hence, we performed a systematic literature review and meta-analysis to assess the correlation between serum zinc concentration and prostate disease. Systematic literature searches were conducted with PubMed, EMBASE, Science Direct/Elsevier, MEDLINE, CNKI and the Cochrane Library up to June 2015 for studies that involved the relationship between serum zinc concentration and prostate disease. Fourteen studies were identified from the databases. Our results illustrated that the serum zinc concentrations in prostate cancer patients were significantly lower than those in Benign prostatic hyperplasia (BPH) patients and normal controls (SMD (95% CI), −0.94 [−1.57, −0.32]; −1.18 [−1.90, −0.45]). However, the serum zinc concentrations in BPH patients were significantly higher than those in normal controls (SMD (95% CI) 1.77 [0.15, 3.39]). The present study showed that different levels of serum zinc concentrations are correlated with different prostatic disease. Serum zinc concentration may be used as a tool for the diagnosis and screening of prostate disease. But, further studies with well-designed larger sample studies are needed in this field to further clarify the correlation between serum zinc concentration and prostate disease.

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Serum zinc level and dietary zinc intake status in non-alcoholic fatty liver disease: A meta-analysis and systematic review

Hepatology Forum ◽

10.14744/hf.2020.2020.0006 ◽

2020 ◽

Author(s):

Nuray Yazihan

Keyword(s):

Systematic Review ◽

Liver Disease ◽

Fatty Liver Disease ◽

Meta Analysis ◽

Serum Zinc ◽

Zinc Level ◽

Serum Zinc Level ◽

Zinc Intake ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

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Dietary zinc intake and whole blood zinc concentration in subjects with type 2 diabetes versus healthy subjects: A systematic review, meta-analysis and meta-regression

Journal of Trace Elements in Medicine and Biology ◽

10.1016/j.jtemb.2018.02.008 ◽

2018 ◽

Vol 49 ◽

pp. 241-251 ◽

Cited By ~ 6

Author(s):

José C. Fernández-Cao ◽

Marisol Warthon-Medina ◽

Victoria Hall Moran ◽

Victoria Arija ◽

Carlos Doepking ◽

...

Keyword(s):

Systematic Review ◽

Type 2 Diabetes ◽

Whole Blood ◽

Healthy Subjects ◽

Zinc Concentration ◽

Meta Analysis ◽

Zinc Intake ◽

Meta Regression ◽

Blood Zinc

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Zinc Intake and Status and Risk of Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Nutrients ◽

10.3390/nu11051027 ◽

2019 ◽

Vol 11 (5) ◽

pp. 1027 ◽

Cited By ~ 8

Author(s):

José C. Fernández-Cao ◽

Marisol Warthon-Medina ◽

Victoria H. Moran ◽

Victoria Arija ◽

Carlos Doepking ◽

...

Keyword(s):

Diabetes Mellitus ◽

Systematic Review ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Zinc Concentration ◽

Meta Analysis ◽

Plasma Zinc ◽

Zinc Intake ◽

Meta Analyses

Zinc could have a protective role against type 2 diabetes mellitus (T2DM). This systematic review and meta-analysis aimed to evaluate the association between dietary, supplementary, and total zinc intake, as well as serum/plasma and whole blood zinc concentration, and risk of T2DM. Observational studies, conducted on cases of incident diabetes or T2DM patients and healthy subjects that reported a measure of association between zinc exposure and T2DM, were selected. Random effects meta-analyses were applied to obtain combined results. Stratified meta-analyses and meta-regressions were executed to assess sources of heterogeneity, as well as the impact of covariates on the findings. From 12,136 publications, 16 studies were selected. The odds ratio (OR) for T2DM comparing the highest versus lowest zinc intake from diet was 0.87 (95% CI: 0.78–0.98). Nevertheless, no association between supplementary or total zinc intake from both diet and supplementation, and T2DM was observed. A direct relationship was found between serum/plasma zinc levels and T2DM (OR = 1.64, 95% CI: 1.25–2.14). A moderately high dietary zinc intake, in relation to the Dietary Reference Intake, could reduce by 13% the risk of T2DM, and up to 41% in rural areas. Conversely, elevated serum/plasma zinc concentration was associated with an increased risk of T2DM by 64%, suggesting disturbances in zinc homeostasis.

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Use of Serum Zinc Concentration as an Indicator of Population Zinc Status

Food and Nutrition Bulletin ◽

10.1177/15648265070283s303 ◽

2007 ◽

Vol 28 (3_suppl3) ◽

pp. S403-S429 ◽

Cited By ~ 139

Author(s):

Sonja Y. Hess ◽

Janet M. Peerson ◽

Janet C. King ◽

Kenneth H. Brown

Keyword(s):

Zinc Deficiency ◽

Zinc Concentration ◽

Zinc Supplementation ◽

Serum Zinc ◽

Interindividual Variation ◽

Zinc Status ◽

Dietary Zinc ◽

Serum Zinc Concentration ◽

Zinc Concentrations ◽

Intervention Trials

Assessing the prevalence and severity of zinc deficiency in populations is critical to determine the need for and appropriate targeting of zinc intervention programs and to assess their effectiveness for improving the health and well-being of high-risk populations. However, there is very little information on the zinc status of populations worldwide due to the lack of consensus on appropriate biochemical indicators of zinc status. The objective of this review was to evaluate the use of serum zinc concentration as an indicator of population zinc status. We have reviewed the response of serum zinc concentration to dietary zinc restriction and zinc supplementation. In addition, we completed pooled analyses of nine zinc intervention trials in young children to assess the relations between serum zinc concentration of individuals before treatment and their responses to zinc supplementation. Also, in updated combined analyses of previously published data, we investigated the relation between the mean initial serum zinc concentration of a study population and their mean growth responses to zinc supplementation in randomized intervention trials among children. The results from depletion/repletion studies indicate that serum zinc concentrations respond appreciably to severe dietary zinc restriction, although there is considerable interindividual variation in these responses. There is also clear evidence that both individual and population mean serum zinc concentrations increase consistently during zinc supplementation, regardless of the initial level of serum zinc concentration. By contrast, an individual's serum zinc concentration does not reliably predict that person's response to zinc supplementation. Serum zinc concentration can be considered a useful biomarker of a population's risk of zinc deficiency and response to zinc interventions, although it may not be a reliable indicator of individual zinc status.

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