Long-Term Effects of Inadequate and Excessive Dietary Ascorbate on Bile Acid Metabolism in the Guinea Pig

1984 ◽  
Vol 114 (8) ◽  
pp. 1370-1376 ◽  
Author(s):  
David E. Holloway ◽  
Jerry M. Rivers
Keyword(s):  
Bile Acid ◽  
Guinea Pig ◽  
Acid Metabolism ◽  
Bile Acid Metabolism ◽  
Long Term Effects

Long-term effects of cholecystectomy on bile acid metabolism

Hepatology ◽  
1995 ◽  
Vol 21 (1) ◽  
pp. 41-45 ◽  
Author(s):  
Gerd-Achim Kullak-Ublick ◽  
Gustav Paumgartner ◽  
Frieder Berr
Keyword(s):  
Bile Acid ◽  
Acid Metabolism ◽  
Bile Acid Metabolism ◽  
Long Term Effects

scholarly journals Effects of long-term ingestion of difructose anhydride III (DFA III) on intestinal bacteria and bile acid metabolism in humans

2006 ◽  
Vol 101 (2) ◽  
pp. 149-156 ◽  
Author(s):  
Kimiko Minamida ◽  
Chikako Asakawa ◽  
I Nengah Sujaya ◽  
Maki Kaneko ◽  
Ayumi Abe ◽  
...  
Keyword(s):  
Bile Acid ◽  
Acid Metabolism ◽  
Intestinal Bacteria ◽  
Bile Acid Metabolism ◽  
Dfa Iii

Effects of dietary cholesterol upon bile acid metabolism in guinea pig

Lipids ◽  
1974 ◽  
Vol 9 (10) ◽  
pp. 731-737 ◽  
Author(s):  
Heleni Lansma ◽  
Rosemarie Ostwald
Keyword(s):  
Bile Acid ◽  
Guinea Pig ◽  
Acid Metabolism ◽  
Dietary Cholesterol ◽  
Bile Acid Metabolism

scholarly journals FGF21 acts as a negative regulator of bile acid synthesis

2018 ◽  
Vol 237 (2) ◽  
pp. 139-152 ◽  
Author(s):  
Michelle M Chen ◽  
Clarence Hale ◽  
Shanaka Stanislaus ◽  
Jing Xu ◽  
Murielle M Véniant
Keyword(s):  
Bile Acid ◽  
Acid Metabolism ◽  
Acid Synthesis ◽  
Bile Acid Synthesis ◽  
Negative Regulator ◽  
Bile Acid Metabolism ◽  
Primary Hepatocytes ◽  
Term Administration ◽  
Long Acting

Fibroblast growth factor 21 (FGF21) is a potent regulator of glucose and lipid homeostasis in vivo; its most closely related subfamily member, FGF19, is known to be a critical negative regulator of bile acid synthesis. To delineate whether FGF21 also plays a functional role in bile acid metabolism, we evaluated the effects of short- and long-term exposure to native FGF21 and long-acting FGF21 analogs on hepatic signal transduction, gene expression and enterohepatic bile acid levels in primary hepatocytes and in rodent and monkey models. FGF21 acutely induced ERK phosphorylation and inhibited Cyp7A1 mRNA expression in primary hepatocytes and in different rodent models, although less potently than recombinant human FGF19. Long-term administration of FGF21 in mice fed a standard chow diet resulted in a 50–60% decrease in bile acid levels in the liver and small intestines and consequently a 60% reduction of bile acid pool size. In parallel, colonic and fecal bile acid was decreased, whereas fecal cholesterol and fatty acid excretions were elevated. The long-acting FGF21 analog showed superiority to recombinant human FGF21 and FGF19 in decreasing bile acid levels with long duration of effect action in mice. Long-term administration of the long-acting FGF21 analogs in obese cynomolgus monkeys suppressed plasma total bile acid and 7α-hydroxy-4-cholesten-3-one levels, a biomarker for bile acid synthesis. Collectively, these data reveal a previously unidentified role of FGF21 in bile acid metabolism as a negative regulator of bile acid synthesis.

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