Transcriptome analysis of 3D primary mouse liver spheroids shows that long-term exposure to hexafluoropropylene oxide trimer acid disrupts hepatic bile acid metabolism

2021 ◽  
pp. 151509
Author(s):  
Sujie Sun ◽  
Jianshe Wang ◽  
Jingzhi Yao ◽  
Hua Guo ◽  
Jiayin Dai
Keyword(s):  
Bile Acid ◽  
Transcriptome Analysis ◽  
Mouse Liver ◽  
Acid Metabolism ◽  
Bile Acid Metabolism ◽  
Hepatic Bile ◽  
Primary Mouse ◽  
Hexafluoropropylene Oxide

scholarly journals Effects of long-term ingestion of difructose anhydride III (DFA III) on intestinal bacteria and bile acid metabolism in humans

2006 ◽  
Vol 101 (2) ◽  
pp. 149-156 ◽  
Author(s):  
Kimiko Minamida ◽  
Chikako Asakawa ◽  
I Nengah Sujaya ◽  
Maki Kaneko ◽  
Ayumi Abe ◽  
...  
Keyword(s):  
Bile Acid ◽  
Acid Metabolism ◽  
Intestinal Bacteria ◽  
Bile Acid Metabolism ◽  
Dfa Iii

scholarly journals Inulin Supplementation Disturbs Hepatic Cholesterol and Bile Acid Metabolism Independent from Housing Temperature

Nutrients ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 3200
Author(s):  
Mira J. Pauly ◽  
Julia K. Rohde ◽  
Clara John ◽  
Ioannis Evangelakos ◽  
Anja Christina Koop ◽  
...  
Keyword(s):  
Bile Acid ◽  
Acid Metabolism ◽  
Plasma Cholesterol ◽  
Cold Treatment ◽  
Short Chain Fatty Acids ◽  
Liver Cholesterol ◽  
Bile Acid Metabolism ◽  
Short Term ◽  
Hepatic Bile ◽  
Brown Adipose

Dietary fibers are fermented by gut bacteria into the major short chain fatty acids (SCFAs) acetate, propionate, and butyrate. Generally, fiber-rich diets are believed to improve metabolic health. However, recent studies suggest that long-term supplementation with fibers causes changes in hepatic bile acid metabolism, hepatocyte damage, and hepatocellular cancer in dysbiotic mice. Alterations in hepatic bile acid metabolism have also been reported after cold-induced activation of brown adipose tissue. Here, we aim to investigate the effects of short-term dietary inulin supplementation on liver cholesterol and bile acid metabolism in control and cold housed specific pathogen free wild type (WT) mice. We found that short-term inulin feeding lowered plasma cholesterol levels and provoked cholestasis and mild liver damage in WT mice. Of note, inulin feeding caused marked perturbations in bile acid metabolism, which were aggravated by cold treatment. Our studies indicate that even relatively short periods of inulin consumption in mice with an intact gut microbiome have detrimental effects on liver metabolism and function.

Long-term effects of cholecystectomy on bile acid metabolism

Hepatology ◽  
1995 ◽  
Vol 21 (1) ◽  
pp. 41-45 ◽  
Author(s):  
Gerd-Achim Kullak-Ublick ◽  
Gustav Paumgartner ◽  
Frieder Berr
Keyword(s):  
Bile Acid ◽  
Acid Metabolism ◽  
Bile Acid Metabolism ◽  
Long Term Effects
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