Inhibition of In Vitro Friend Murine Leukemia Virus Infection of Lipopolysaccharide-Activated B-Cells With Concanavalin A2

1979 ◽  
Keyword(s):  
B Cells ◽  
Virus Infection ◽  
Concanavalin A ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Murine Leukemia ◽  
Activated B Cells

T-cells inhibit Friend murine leukemia virus infection of B-cells in vitro

1989 ◽  
Vol 120 (2) ◽  
pp. 375-386 ◽  
Author(s):  
Dale D. Isaak ◽  
Robert Fleischmann ◽  
Jan Cerny
Keyword(s):  
T Cells ◽  
B Cells ◽  
Virus Infection ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Murine Leukemia

Effect of interferon on the exogenous friend murine leukemia virus infection

Virology ◽  
1982 ◽  
Vol 118 (1) ◽  
pp. 202-213 ◽  
Author(s):  
Charles H. Riggin ◽  
Paula M. Pithai
Keyword(s):  
Virus Infection ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Murine Leukemia

scholarly journals Sequential activation of the three protomers in the Moloney murine leukemia virus Env

2017 ◽  
Vol 114 (10) ◽  
pp. 2723-2728 ◽  
Author(s):  
Mathilda Sjöberg ◽  
Robin Löving ◽  
Birgitta Lindqvist ◽  
Henrik Garoff
Keyword(s):  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Moloney Murine Leukemia Virus ◽  
Virus Envelope ◽  
Sequential Activation ◽  
Virus Envelope Protein ◽  
Membrane Fusion Proteins ◽  
Viral Membrane Fusion ◽  
Murine Leukemia

Viral membrane fusion proteins of class I are trimers in which the protomeric unit is a complex of a surface subunit (SU) and a fusion active transmembrane subunit (TM). Here we have studied how the protomeric units of Moloney murine leukemia virus envelope protein (Env) are activated in relation to each other, sequentially or simultaneously. We followed the isomerization of the SU-TM disulfide and subsequent SU release from Env with biochemical methods and found that this early activation step occurred sequentially in the three protomers, generating two asymmetric oligomer intermediates according to the scheme (SU-TM)3→ (SU-TM)2TM → (SU-TM)TM2→ TM3. This was the case both when activation was triggered in vitro by depleting stabilizing Ca2+from solubilized Env and when viral Env was receptor triggered on rat XC cells. In the latter case, the activation reaction was too fast for direct observation of the intermediates, but they could be caught by alkylation of the isomerization active thiol.

Heterogeneity of Murine Leukemia Virus in vitro DNA; Detection of Viral DNA in Mammalian Cells

Science ◽  
1971 ◽  
Vol 172 (3990) ◽  
pp. 1353-1355 ◽  
Author(s):  
L. D. Gelb ◽  
S. A. Aaronson ◽  
M. A. Martin
Keyword(s):  
Murine Leukemia Virus ◽  
Mammalian Cells ◽  
Dna Detection ◽  
Leukemia Virus ◽  
Viral Dna ◽  
Murine Leukemia

scholarly journals trans-dominant interference with virus infection at two different stages by a mutant envelope protein of Friend murine leukemia virus.

1993 ◽  
Vol 67 (4) ◽  
pp. 2026-2033 ◽  
Author(s):  
T Matano ◽  
T Odawara ◽  
M Ohshima ◽  
H Yoshikura ◽  
A Iwamoto
Keyword(s):  
Virus Infection ◽  
Envelope Protein ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Murine Leukemia

scholarly journals Susceptibility of human primary neuronal cells to Xenotropic Murine Leukemia Virus-related (XMRV) virus infection

2011 ◽  
Vol 8 (1) ◽  
pp. 443 ◽  
Author(s):  
Veerasamy Ravichandran ◽  
Eugen O Major ◽  
Carol Ibe ◽  
Maria Monaco ◽  
Mohan Girisetty ◽  
...  
Keyword(s):  
Virus Infection ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Neuronal Cells ◽  
Xenotropic Murine Leukemia ◽  
Primary Neuronal Cells ◽  
Murine Leukemia

Strong selection for cells containing new ecotropic recombinant murine leukemia virus provirus after propagation of C57BL/6 radiation-induced thymoma cells in vitro or in vivo

1983 ◽  
Vol 3 (9) ◽  
pp. 1675-1679
Author(s):  
P Jolicoeur ◽  
E Rassart ◽  
P Sankar-Mistry
Keyword(s):  
Cell Lines ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Primary Radiation ◽  
Secondary Tumors ◽  
Radiation Induced ◽  
Viral Sequences ◽  
Murine Leukemia

Using the Southern procedure, we have studied the presence of ecotropic-specific murine leukemia viral sequences in genomic DNA isolated from primary X-ray-induced thymomas, from lymphoid cell lines established from them, or from secondary tumors passaged in vivo. We found that primary radiation-induced thymomas and infiltrated spleens do not harbor newly acquired ecotropic provirus. However, additional ecotropic proviruses (which appear recombinant in the gagpol region) could be detected in most of the tumorigenic cell lines established in vitro from them and in tumors arising from subcutaneous transplantation of the primary thymomas. These results suggest that primary radiation-induced thymomas may not be clonal. They also indicate a strong correlation between the presence of ecotropic recombinant proviruses in the genome and the growth ability, both in vitro and in vivo, of specific cells within these thymomas, suggesting a possible mitogenic function for murine leukemia virus.

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