scholarly journals Smoking Cessation After Lung Cancer Diagnosis and the Risk of Second Primary Lung Cancer: The Multiethnic Cohort Study

2021 ◽  
Vol 5 (5) ◽  
Author(s):  
Sophia J Luo ◽  
Eunji Choi ◽  
Jacqueline V Aredo ◽  
Lynne R Wilkens ◽  
Martin C Tammemägi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Smoking Cessation ◽  
Cohort Study ◽  
Cancer Diagnosis ◽  
Primary Lung Cancer ◽  
Second Primary ◽  
Lung Cancer Diagnosis ◽  
Second Primary Lung Cancer ◽  
Multiethnic Cohort

Abstract Background Smoking cessation reduces lung cancer mortality. However, little is known about whether diagnosis of lung cancer impacts changes in smoking behaviors. Furthermore, the effects of smoking cessation on the risk of second primary lung cancer (SPLC) have not been established yet. This study aims to examine smoking behavior changes after initial primary lung cancer (IPLC) diagnosis and estimate the effect of smoking cessation on SPLC risk following IPLC diagnosis. Methods The study cohort consisted of 986 participants in the Multiethnic Cohort Study who were free of lung cancer and active smokers at baseline (1993-1996), provided 10-year follow-up smoking data (2003-2008), and were diagnosed with IPLC in 1993-2017. The primary outcome was a change in smoking status from “current” at baseline to “former” at 10-year follow-up (ie, smoking cessation), analyzed using logistic regression. The second outcome was SPLC incidence after smoking cessation, estimated using cause-specific Cox regression. All statistical tests were 2-sided. Results Among 986 current smokers at baseline, 51.1% reported smoking cessation at 10-year follow-up. The smoking cessation rate was statistically significantly higher (80.6%) for those diagnosed with IPLC between baseline and 10-year follow-up vs those without IPLC diagnosis (45.4%) during the 10-year period (adjusted odds ratio = 5.12, 95% confidence interval [CI] = 3.38 to 7.98; P < .001). Incidence of SPLC was statistically significantly lower among the 504 participants who reported smoking cessation at follow-up compared with those without smoking cessation (adjusted hazard ratio = 0.31, 95% CI = 0.14 to 0.67; P = .003). Conclusion Lung cancer diagnosis has a statistically significant impact on smoking cessation. Quitting smoking after IPLC diagnosis may reduce the risk of developing a subsequent malignancy in the lungs.

scholarly journals Routine follow-up after surgical treatment of lung cancer: is chest CT useful?

2021 ◽  
pp. e20210025 ◽  
Author(s):  
Juliana B F Morellato1 ◽  
Marcos D Guimarães2 ◽  
Maria L L Medeiros1 ◽  
Hélio A Carneiro1 ◽  
Alex D Oliveira2 ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Surgical Resection ◽  
Primary Lung Cancer ◽  
Cancer Recurrence ◽  
Chest Ct ◽  
Second Primary ◽  
Medical Visits ◽  
Asymptomatic Patients ◽  
Second Primary Lung Cancer

Objective: To report the experience of a routine follow-up program based on medical visits and chest CT. Methods: This was a retrospective study involving patients followed after complete surgical resection of non-small cell lung cancer between April of 2007 and December of 2015. The follow-up program consisted of clinical examination and chest CT. Each follow-up visit was classified as a routine or non-routine consultation, and patients were considered symptomatic or asymptomatic. The outcomes of the follow-up program were no evidence of cancer, recurrence, or second primary lung cancer. Results: The sample comprised 148 patients. The median time of follow-up was 40.1 months, and 74.3% of the patients underwent fewer chest CTs than those recommended in our follow-up program. Recurrence and second primary lung cancer were found in 17.6% and 11.5% of the patients, respectively. Recurrence was diagnosed in a routine medical consultation in 69.2% of the cases, 57.7% of the patients being asymptomatic. Second primary lung cancer was diagnosed in a routine medical appointment in 94.1% of the cases, 88.2% of the patients being asymptomatic. Of the 53 patients who presented with abnormalities on chest CT, 41 (77.3%) were diagnosed with cancer. Conclusion: Most of the cases of recurrence, especially those of second primary lung cancer, were confirmed by chest CT in asymptomatic patients, indicating the importance of a strict follow-up program that includes chest CTs after surgical resection of lung cancer.

scholarly journals Second primary lung cancer: importance of long term follow up.

Thorax ◽  
1989 ◽  
Vol 44 (10) ◽  
pp. 788-793 ◽  
Author(s):  
P C van Bodegom ◽  
S S Wagenaar ◽  
B Corrin ◽  
J P Baak ◽  
J Berkel ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Primary Lung Cancer ◽  
Second Primary ◽  
Second Primary Lung Cancer ◽  
Long Term Follow Up

scholarly journals Radiotherapy was associated with the lower incidence of metachronous second primary lung cancer

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Zhi Gang Hu ◽  
Yu Feng Tian ◽  
Wen Xin Li ◽  
Fan Jun Zeng
Keyword(s):  
Lung Cancer ◽  
Regression Analysis ◽  
Propensity Score ◽  
Primary Lung Cancer ◽  
Second Primary ◽  
Competing Risk Analysis ◽  
Joinpoint Regression ◽  
Joinpoint Regression Analysis ◽  
Second Primary Lung Cancer

AbstractOur study aims to estimate the incidence of metachronous second primary lung cancer(SPLC) in initial primary lung cancer(IPLC) survivors and to determine whether radiotherapy affects the risk of metachronous SPLC in the first five years after the diagnosis of lung cancer. Incidence data of IPLC individuals who survived ≥2 years were obtained from SEER-18 database in 2004–2007. Joinpoint regression analysis and competing risk analysis were used to calculate the incidence of metachronous SPLC. Propensity score matching and decision analysis were available to estimate the effect of radiotherapy on metachronous SPLC. 264 of 11657 IPLC survivors with radiotherapy and 1090 of 24499 IPLC survivors without radiotherapy developed metachronous SPLC during 5-year follow-up, respectively. In joinpoint regression analysis, the 5-year incidence of metachronous SPLC in the radiotherapy group was lower than that in the nonradiotherapy group(2385 per 100,000 vs 4748 per 100,000, HR = 0.43,95% CI:0.39–0.47). Competing risk analysis showed that the survivors with radiotherapy were associated with the lower 5 year incidence of metachronous SPLC compared with those without radiotherapy(2.28% vs 4.47%, HR = 0.49,95% CI:0.43–0.57). Through propensity score matching, 4077 pairs of survivors were available to further study that radiotherapy potentially decreased the risk of developing metachronous SPLC with the adjustment of various factors(2.5% vs 3.3%, HR = 0.72, 95% CI:0.55–0.96). Decision analysis suggested that radiotherapy was a negative independent risk factor of metachronous SPLC with clinical net benefit in a range of risk thresholds (2% to 5%). Survivors of IPLC with radiotherapy likely had a low risk of metachronous SPLC during the first five years follow-up, especially non-small cell lung cancer.

Second primary lung cancer and relapse: treatment and follow-up

1995 ◽  
Vol 9 (11) ◽  
pp. 607-611 ◽  
Author(s):  
C ANGELETTI ◽  
A MUSSI ◽  
A JANNI ◽  
M LUCCHI ◽  
A RIBECHINI ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Primary Lung Cancer ◽  
Second Primary ◽  
Relapse Treatment ◽  
Second Primary Lung Cancer

Second pulmonary resection for a second primary lung cancer: analysis of morbidity and survival

2020 ◽  
Author(s):  
Walid Abid ◽  
Agathe Seguin-Givelet ◽  
Emmanuel Brian ◽  
Madalina Grigoroiu ◽  
Philippe Girard ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Median Overall Survival ◽  
Pulmonary Resection ◽  
Early Stage ◽  
Wedge Resection ◽  
Tumour Size ◽  
Primary Lung Cancer ◽  
Second Primary ◽  
Second Primary Lung Cancer

Abstract OBJECTIVES Evaluating morbidity and survival of patients operated on for a second primary non-small-cell lung cancer (NSCLC). METHODS Retrospective collection of data from patients operated on for a second NSCLC between 2009 and 2018. RESULTS Fifty-two patients met the inclusion criteria. At the time of second pulmonary resection, the median time between the 2 surgeries was 25 months (5–44.5 months). Patients’ median age was 65 years (61–68 years). Median tumour size was 16 mm (10–22 mm). Thoracoscopy was used in 75% of cases. The resection was a pneumonectomy (n = 1), bilobectomy (n = 1), lobectomy (n = 15), segmentectomy (n = 32) or wedge resection (n = 3). The length of stay was 7 days (5–9 days). Mortality was null and morbidity was 36.5%, mainly from grade I–II complications according to the Clavien–Dindo classification. The median follow-up was 28 months (13–50 months). The median overall survival was 67 months (95% confidence interval 60.8–73.1 months). Survival at 5 years and specific survival were 71.1% and 67.7%, respectively. CONCLUSIONS A second surgical resection of either synchronous or metachronous NSCLC has a morbidity that is not superior to the morbidity of the first operation. The new tumour is usually diagnosed at an early stage. An anatomical sublobar resection is most likely the best compromise. It might also be considered for the first operation when there is a suspicious synchronous lesion that may require surgery at a later stage.

Sign in / Sign up

Export Citation Format

Share Document