Coinfection With Human Herpesvirus (HHV)-6B in Immunocompetent, Healthy Individuals With Chromosomally Integrated HHV-6A

2020 ◽  
Author(s):  
Hiroki Miura ◽  
Tamae Ohye ◽  
Kei Kozawa ◽  
Fumihiko Hattori ◽  
Yoshiki Kawamura ◽  
...  
Keyword(s):  
Clinical Features ◽  
Human Herpesvirus ◽  
Healthy Individuals ◽  
Exanthema Subitum

Abstract Immunocompetent sisters with chromosomally integrated human herpesvirus 6A (HHV-6A) transiently excreted HHV-6B genome in their saliva. They did not have past histories of exanthema subitum but had antibodies against HHV-6A and HHV-6B. This suggests that endogenous HHV-6A may modify the clinical features of HHV-6B coinfection.

Clinical Features and Hepatic Molecular Characteristics in NAFLD and NASH Patients Compared to Normal Weight Healthy Individuals

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 260-LB
Author(s):  
MALTE P. SUPPLI ◽  
KRISTOFFER RIGBOLT ◽  
SANNE VEIDAL ◽  
SARA HEEBØLL ◽  
MIA DEMANT ◽  
...  
Keyword(s):  
Clinical Features ◽  
Normal Weight ◽  
Molecular Characteristics ◽  
Healthy Individuals

Clinical Features and Virological Findings in Children With Primary Human Herpesvirus 7 Infection

PEDIATRICS ◽  
1997 ◽  
Vol 99 (3) ◽  
pp. e4-e4 ◽  
Author(s):  
S. Suga ◽  
T. Yoshikawa ◽  
T. Nagai ◽  
Y. Asano
Keyword(s):  
Clinical Features ◽  
Human Herpesvirus

scholarly journals Detection of human herpesvirus 7 infection in young children presenting with exanthema subitum

2011 ◽  
Vol 106 (3) ◽  
pp. 371-373 ◽  
Author(s):  
Ivna de Melo Magalhães ◽  
Rebeca Vazquez Novo Martins ◽  
Renata Oliveira Vianna ◽  
Natalia Moysés ◽  
Larissa Alves Afonso ◽  
...  
Keyword(s):  
Young Children ◽  
Human Herpesvirus ◽  
Exanthema Subitum

Hepatitis in Association With Human Herpesvirus-7 Infection

PEDIATRICS ◽  
1995 ◽  
Vol 96 (4) ◽  
pp. 783-785
Author(s):  
Tetsuo Hashida ◽  
Emiko Komura ◽  
Maki Yoshida ◽  
Takuji Otsuka ◽  
Shigeyoshi Hibi ◽  
...  
Keyword(s):  
Hemophagocytic Syndrome ◽  
Mononuclear Cells ◽  
Organ Transplant ◽  
Human Herpesvirus ◽  
Chronic Fatigue ◽  
Peripheral Blood Mononuclear ◽  
Barr Virus ◽  
Transplant Patients ◽  
Exanthema Subitum ◽  
Epstein Barr

Human herpesvirus-7 (HHV-7), a newly identified lymphotropic member of the herpes family, has recently been isolated from the peripheral blood mononuclear cells (PBMC) of healthy individuals.1 Similar to human herpesvirus-6 (HHV-6), HHV-7 has been found to prevalently infect children at younger ages.2-4 HHV-6 is known to be a causative agent of exanthema subitum,5 and has also been identified in cases of fatal fulminant hepatitis,6 hemophagocytic syndrome,7 encephalitis,8 and intussusception.9 Moreover, HHV-6 infection with severe consequences has been reported in bone marrow and organ transplant patients undergoing immunosuppressive therapy.10-12 Although HHV-7 has recently been isolated from the PBMC of the patients with chronic fatigue syndrome13 and of a child with symptoms mimicking chronic Epstein Barr virus (EBV) infection,14 it is as yet unknown what other diseases are associated with this newly isolated HHV-7 virus infection.

Antiprothrombin antibodies detected in two different assay systems

2005 ◽  
Vol 93 (02) ◽  
pp. 289-297 ◽  
Author(s):  
Tatsuya Atsumi ◽  
Takao Koike ◽  
Graham Hughes ◽  
Munther Khamashta ◽  
Maria Bertolaccini
Keyword(s):  
Clinical Significance ◽  
Clinical Features ◽  
Clinical Benefit ◽  
Protein S ◽  
Healthy Individuals ◽  
Obstetric History ◽  
Antiprothrombin Antibodies ◽  
Standard Tests

SummaryWe evaluated the clinical significance of aPT and aPS-PT by testing for the presence of these antibodies in 212 SLE patients and in 100 healthy individuals. Results show that anti-prothrombin antibodies were found in 47% of the patients (aPT in 31% and aPS-PT in 31%). Their presence did not correlate with that of aCL, anti-β 2GPI, LA and/or anti-protein S. IgG but not IgM aPT were more frequently found in patients with thrombosis than in those without. IgG and IgM aPS-PT were also more frequent in patients with thrombosis (venous and/or arterial) than in those without. Levels of IgG aPT and IgG and IgM aPS-PT were higher in patients with thrombosis than in those without. Although aPT and aPS-PT were more frequently found in women with adverse obstetric history than in those without, the differences were not statistically significant. More significantly, 48% of the patients with aPL-related clinical features who were negative for standard tests had antiprothrombin antibodies. We can conclude that aPT and aPS-PT are frequently found in SLE. Their presence is associated with thrombosis, making these antibodies potential markers for the APS. Testing for these antibodies could be of clinical benefit in patients who are negative for the routinely used tests.

Clinical Features of Complex Febrile Seizure Caused by Primary Human Herpesvirus 6B Infection

2020 ◽  
Vol 109 ◽  
pp. 52-55 ◽  
Author(s):  
Misa Miyake ◽  
Yoshiki Kawamura ◽  
Fumihiko Hattori ◽  
Hiroki Miura ◽  
Naoko Ishihara ◽  
...  
Keyword(s):  
Clinical Features ◽  
Febrile Seizure ◽  
Human Herpesvirus

scholarly journals Detection of human herpesvirus-7 by qualitative nested-PCR: comparison between healthy individuals and liver transplant recipients

2008 ◽  
Vol 41 (6) ◽  
pp. 556-559 ◽  
Author(s):  
Ronaldo Luis Thomasini ◽  
Juliana de Moraes Martins ◽  
Daniela Corte Parola ◽  
Sandra Helena Alves Bonon ◽  
Ilka de Fátima Santana Ferreira Boin ◽  
...  
Keyword(s):  
Liver Transplant ◽  
Healthy Volunteers ◽  
Nested Pcr ◽  
Human Herpesvirus ◽  
Transplant Recipients ◽  
Healthy Individuals ◽  
Active Infection ◽  
Serological Tests ◽  
Transplant Patients ◽  
Liver Transplant Recipients

Diagnosis of human herpesvirus-7 active infection in transplant patients has proved difficult, because this virus is ubiquitous and can cause persistent infections in the host. The significance of viral DNA detected in leukocytes by PCR is unclear and cross-reaction in serological tests may occur. This study aimed to evaluate nested-PCR to detect human herpesvirus-7 active infection in liver transplant recipients compared to healthy individuals. human herpesvirus-7 nested-PCR was performed on leukocytes and sera of 53 healthy volunteers and sera of 29 liver transplant recipients. In healthy volunteers, human herpesvirus-7 was detected in 28.3% of leukocytes and 0% of serum. human herpesvirus-7 was detected in sera of 48.2% of the liver transplant recipients. Nested-PCR on DNA extracted from leukocytes detected latent infection and the study suggests that nested-PCR performed on serum could be useful to detect human herpesvirus-7 active infection in liver transplant recipients.

scholarly journals Effect of Prophylactic Valacyclovir on the Presence of Human Herpesvirus DNA in Saliva of Healthy Individuals after Dental Treatment

2005 ◽  
Vol 43 (5) ◽  
pp. 2173-2180 ◽  
Author(s):  
C. S. Miller ◽  
S. A. Avdiushko ◽  
R. J. Kryscio ◽  
R. J. Danaher ◽  
R. J. Jacob
Keyword(s):  
Dental Treatment ◽  
Human Herpesvirus ◽  
Healthy Individuals
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