Pleomorphic Calcifications

2018 ◽  
Author(s):  
Stephanie A. Lee-Felker ◽  
Colin J. Wells
Keyword(s):  
Needle Biopsy ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Calcium Deposition ◽  
Imaging Features ◽  
Triangular Shape ◽  
Imaging Protocols ◽  
Multifocal Breast Cancer ◽  
Management Recommendations

Pleomorphic calcifications are categorized among calcifications with suspicious morphology: amorphous, coarse heterogeneous, fine linear or fine-linear branching, and fine pleomorphic calcifications. Unlike amorphous calcifications, pleomorphic calcifications are more conspicuous, with discernible shapes that appear predominantly irregular, and are variable in size and configuration. A segmental distribution, seen as a triangular shape with its apex centered at the nipple, is especially suspicious for ductal carcinoma in situ (DCIS) or multifocal breast cancer, as its pattern of calcium deposition suggests involvement of a duct system within the breast. This chapter, appearing in the section on calcifications, reviews the key clinical and imaging features, imaging protocols, differential diagnoses, and management recommendations for pleomorphic calcifications. Topics discussed include characteristic morphology and distribution of pleomorphic calcifications, BI-RADS assessments, core needle biopsy, and radiological–pathological correlation.

Secretory Calcifications

2018 ◽  
Author(s):  
Christopher P. Ho
Keyword(s):  
Carcinoma In Situ ◽  
Plasma Cells ◽  
Ductal Carcinoma ◽  
Close Association ◽  
Epithelial Hyperplasia ◽  
Appropriate Use ◽  
Imaging Protocols ◽  
Management Recommendations

Secretory calcifications are large rod-like calcifications that are often seen in a linear or segmental distribution. They can often be easily differentiated from more malignant-appearing calcifications because they are smooth and much coarser than calcifications seen with ductal carcinoma in situ (DCIS). Secretory calcifications are thought to be associated with duct ectasia and have been historically referred to as “plasma cell mastitis” because of the close association of plasma cells within the ductal infiltrates and epithelial hyperplasia. This chapter, appearing in the section on calcifications, reviews the key imaging and clinical features, imaging protocols and pitfalls, differential diagnoses, and management recommendations for secretory calcifications. Topics discussed include appropriate use of magnification views, how to differentiate the calcifications from more suspicious ones, and appropriate follow-up.

Fine, Linear/Branching Calcifications

2018 ◽  
Author(s):  
Laura Doepke
Keyword(s):  
Positive Predictive Value ◽  
Predictive Value ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Imaging Features ◽  
Imaging Protocols ◽  
Risk Of Malignancy ◽  
Stereotactic Core Needle Biopsy ◽  
Stereotactic Core

Of all of the calcifications identified on mammography, fine, linear/branching calcifications are the most suspicious for malignancy, most commonly ductal carcinoma in situ (DCIS). The risk of malignancy associated with fine, linear/branching calcifications is approximately 70%. A recent study evaluating the positive predictive value of suspicious calcifications based on the fifth edition of BI-RADS found the positive predictive value of fine pleomorphic/linear or segmental calcifications was 93.8%. This chapter, which appears in the section on calcifications, reviews the key imaging features, imaging protocols for evaluating calcifications, management, and potential pitfalls or mimics of fine, linear/branching calcifications. Topics discussed will include magnification views, stereotactic core needle biopsy, and radiology–pathology correlation.

Amorphous/Indistinct Calcifications (Group)

2018 ◽  
Author(s):  
Lilian Wang
Keyword(s):  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Atypical Ductal Hyperplasia ◽  
Morphological Classification ◽  
Imaging Protocols ◽  
Fibrocystic Change ◽  
Ductal Hyperplasia ◽  
Management Recommendations

Amorphous calcifications are calcifications that are sufficiently small and/or hazy that a more specific morphological classification cannot be made. Historically, such calcifications were referred to as “indistinct” calcifications. The likelihood of malignancy and the management of amorphous calcifications largely depend on their distribution. This chapter, appearing in the section on calcifications, reviews the key imaging and clinical features, imaging protocols and pitfalls, differential diagnosis with radiology–pathology correlation, and management recommendations for amorphous/indistinct calcifications in a group. Topics discussed include spot magnification views for characterization, role of distribution in BI-RADS assessment, and pathological entities, including fibrocystic change, milk of calcium, atypical ductal hyperplasia (ADH), and ductal carcinoma in situ (DCIS).

scholarly journals Encapsulated Papillary Carcinoma of the Breast: Imaging Features with Histopathologic Correlation

2020 ◽  
Vol 2 (6) ◽  
pp. 590-597
Author(s):  
Sarah E Bonnet ◽  
Gloria J Carter ◽  
Wendie A Berg
Keyword(s):  
Papillary Carcinoma ◽  
Core Needle Biopsy ◽  
Needle Biopsy ◽  
Breast Imaging ◽  
Ductal Carcinoma ◽  
Imaging Features ◽  
Term Survival ◽  
Core Needle ◽  
Cystic Component

Abstract Encapsulated papillary carcinoma (EPC) is a rare, clinically indolent breast malignancy most common in postmenopausal women. Absence of myoepithelial cells at the periphery is a characteristic feature. Mammographically, EPC typically presents as a mostly circumscribed, noncalcified, dense mass that can have focally indistinct margins when there is associated frank invasive carcinoma. Ultrasound shows a circumscribed solid or complex cystic and solid mass, and occasional hemorrhage in the cystic component may produce a fluid-debris level; the solid components typically show intense washout enhancement on MRI. Color Doppler may demonstrate a prominent vascular pedicle and blood flow within solid papillary fronds. Encapsulated papillary carcinoma can exist in pure form; however, EPC is often associated with conventional ductal carcinoma in-situ and/or invasive ductal carcinoma, no special type. Adjacent in-situ and invasive disease may be only focally present at the periphery of EPC and potentially unsampled at core-needle biopsy. In order to facilitate diagnosis, the mass wall should be included on core-needle biopsy, which will show absence of myoepithelial markers. Staging and prognosis are determined by any associated frankly invasive component, with usually excellent long-term survival and rare distant metastases.

Ductal and lobular carcinoma in situ arising within an enlarging biopsy proven fibroadenoma

2021 ◽  
Vol 14 (1) ◽  
pp. e237017
Author(s):  
Yara Z Feliciano ◽  
Rochelle Freire ◽  
Jose Net ◽  
Monica Yepes
Keyword(s):  
Needle Biopsy ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Incidental Finding ◽  
Case Reports ◽  
Lobular Carcinoma ◽  
Lobular Carcinoma In Situ ◽  
Current Case ◽  
Malignant Changes

The diagnosis via core needle biopsy of concurrent ductal carcinoma in situ and lobular carcinoma in situ within an enlarging previously biopsied benign fibroadenoma in women in their 40s is rare. Several case reports have described the occurrence of malignant changes within fibroadenomas, usually as an incidental finding following excision, and few reports have documented the transition of a fibroadenoma to malignancy. The current case report emphasises the importance of re-biopsying enlarging fibroadenomas, even with otherwise maintained benign appearing features on imaging, in women in their 40s, in order to exclude the possibility of malignancy.

Ductal carcinoma in situ diagnosed by breast needle biopsy: Predictors of invasion in the excision specimen

The Breast ◽  
2016 ◽  
Vol 27 ◽  
pp. 15-21 ◽  
Author(s):  
S.C. Doebar ◽  
C. de Monyé ◽  
H. Stoop ◽  
J. Rothbarth ◽  
S.P. Willemsen ◽  
...  
Keyword(s):  
Ductal Carcinoma In Situ ◽  
Needle Biopsy ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma

scholarly journals Ductal Carcinoma in situ after Core Needle Biopsy: In Which Cases Is a Sentinel Node Biopsy Necessary?

Breast Care ◽  
2019 ◽  
Vol 15 (3) ◽  
pp. 260-264
Author(s):  
Robbert J.H. van Leeuwen ◽  
Birgitta Kortmann ◽  
Herman Rijna
Keyword(s):  
Sentinel Node ◽  
Sentinel Node Biopsy ◽  
Ductal Carcinoma In Situ ◽  
Core Needle Biopsy ◽  
Needle Biopsy ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Core Needle ◽  
Node Biopsy

Introduction: In some hospitals it is still common practice to carry out a sentinel node biopsy (SNB) if ductal carcinoma in situ (DCIS) is determined in preoperative staging, although this is against international guidelines. The reason for this is because an infiltrative component can be demonstrated frequently in the final pathohistological examination. In this study, we wanted to investigate possible predictors for infiltrative growth, to select patients to do an SNB or to omit it. Material and Methods: All patients with DCIS in the core needle biopsy (CNB), who were treated with surgery including an SNB, were included in a prospective data registry. Patient characteristics were collected through physical examination, mammography and ultrasonography. All characteristics of the DCIS were noted. After surgery, the pathological results were collected. Results: From the 287 patients, 39 (13.6%) had an infiltrative component in the definitive pathological examination despite only DCIS in preoperative CNB. In total, there were only 14 (4.9%) positive SNBs, of which 11 patients had infiltrative growth in the breast tumor and 3 (1.2% of patients with DCIS alone in the final pathology) did not. In addition, characteristics of the CNB, including microcalcifications and comedonecrosis, did not show a statistically significant higher risk for infiltration. Discussion: Considering the low rates of positive SNBs in our population, we think that an SNB should not be performed in advance when DCIS is diagnosed, because if infiltrative growth is found in the final biopsy, an SNB could always be performed afterwards. Only if an SNB cannot be performed afterwards is an SNB indicated.

Ductal carcinoma in situ presenting as microcalcifications: the effect of stereotactic large-core needle biopsy on surgical therapy

The Breast ◽  
2004 ◽  
Vol 13 (6) ◽  
pp. 461-467 ◽  
Author(s):  
M.A.J. de Roos ◽  
R.M. Pijnappel ◽  
A.D. Groote ◽  
J. de Vries ◽  
W.J. Post ◽  
...  
Keyword(s):  
Surgical Therapy ◽  
Ductal Carcinoma In Situ ◽  
Core Needle Biopsy ◽  
Needle Biopsy ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Large Core ◽  
Core Needle
Sign in / Sign up

Export Citation Format

Share Document