Parvovirus

2018 ◽  
Author(s):  
Amol Purandare ◽  
Barbara A. Jantausch
Keyword(s):  
Parvovirus B19 ◽  
Antiviral Agents ◽  
Neurodevelopmental Outcome ◽  
Congenital Infection ◽  
Future Research ◽  
Fetal Anemia ◽  
Intrauterine Transfusion ◽  
History Of ◽  
Parvovirus B19 Infection ◽  
Neurodevelopmental Impairment

Parvovirus B19 is a common infection in humans that occurs worldwide. Parvovirus B19 is transmitted through exposure to respiratory droplets, blood, and blood products, and through mother-to-child transmission (MTCT) in utero. Intrauterine parvovirus B19 infection is a rare occurrence during pregnancy but can result in significant morbidity and mortality for the fetus, including severe fetal anemia and nonimmune fetal hydrops (NIFH). Intrauterine transfusion can be successful in treating fetal anemia. Neurodevelopmental impairment has been reported in infants with congenital infection who have received intrauterine transfusion (IUT). Future research on the development of antiviral agents for the treatment of parvovirus B19 infection in pregnant women is needed, along with the development of a parvovirus B19 vaccine. Longitudinal studies to evaluate neurodevelopmental outcome of infants with a history of congenital parvovirus B19 infection are needed in order to facilitate the optimal evaluation and management of these infants.

Intrauterine transfusion for parvovirus B19 infection: long-term neurodevelopmental outcome

2012 ◽  
Vol 206 (3) ◽  
pp. 204.e1-204.e5 ◽  
Author(s):  
Eveline P. De Jong ◽  
Irene T. Lindenburg ◽  
Jeanine M. van Klink ◽  
Dick Oepkes ◽  
Inge L. van Kamp ◽  
...  
Keyword(s):  
Parvovirus B19 ◽  
Neurodevelopmental Outcome ◽  
Intrauterine Transfusion ◽  
Parvovirus B19 Infection

History of parvovirus B19 infection is associated with silent cerebral infarcts

2017 ◽  
Vol 65 (1) ◽  
pp. e26767 ◽  
Author(s):  
Foluso J. Ogunsile ◽  
Kelli L. Currie ◽  
Mark Rodeghier ◽  
Adetola Kassim ◽  
Michael R. DeBaun ◽  
...  
Keyword(s):  
Parvovirus B19 ◽  
Cerebral Infarcts ◽  
History Of ◽  
Parvovirus B19 Infection

scholarly journals History of parvovirus B19 infection is associated with a DNA methylation signature in childhood acute lymphoblastic leukemia

Epigenetics ◽  
2011 ◽  
Vol 6 (12) ◽  
pp. 1436-1443 ◽  
Author(s):  
Gisele M. Vasconcelos ◽  
Brock C. Christensen ◽  
E. Andrés Houseman ◽  
Jianqiao Xiao ◽  
Carmen J. Marsit ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Acute Lymphoblastic Leukemia ◽  
Parvovirus B19 ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
History Of ◽  
Parvovirus B19 Infection

scholarly journals First-trimester treatment of fetal anemia secondary to parvovirus B19 infection

2007 ◽  
Vol 29 (2) ◽  
pp. 226-228 ◽  
Author(s):  
A. Kempe ◽  
B. Rösing ◽  
C. Berg ◽  
D. Kamil ◽  
A. Heep ◽  
...  
Keyword(s):  
Parvovirus B19 ◽  
First Trimester ◽  
Fetal Anemia ◽  
Parvovirus B19 Infection

35: Long-term neurodevelopment in children after intrauterine transfusion for Parvovirus B19 infection

2012 ◽  
Vol 206 (1) ◽  
pp. S22-S23
Author(s):  
Jeanine van Klink ◽  
Dick Oepkes ◽  
Irene Lindenburg ◽  
Inge van Kamp ◽  
Enrico Lopriore
Keyword(s):  
Parvovirus B19 ◽  
Intrauterine Transfusion ◽  
Parvovirus B19 Infection

A Case Report of Parvovirus B19 Infection in a Renal Allograft

2017 ◽  
Vol 25 (7) ◽  
pp. 648-651
Author(s):  
Diana M. Oramas ◽  
Suman Setty ◽  
Vijay Yeldandi ◽  
Julio Cabrera ◽  
Tushar Patel
Keyword(s):  
Renal Allograft ◽  
Parvovirus B19 ◽  
Solid Organ Transplantation ◽  
Refractory Anemia ◽  
Solid Organ ◽  
Previous Infection ◽  
Risk Patients ◽  
History Of ◽  
Parvovirus B19 Infection ◽  
Viral Inclusions

Parvovirus B19 infection is undiagnosed in recipients undergoing solid organ transplantation. It is usually responsible for unexplained acute and chronic red blood cell aplasia that does not respond to erythropoietin therapy. Cases of parvovirus B19 infection associated with pancytopenia, solid organ dysfunction, and allograft rejection have been described in the literature. The deterioration of the immune system as a result of severe immunotherapy favors the reactivation of a previous infection or the acquisition of a new one. We present a case of a 32-year-old woman with a 1-year history of renal allograft transplant and previous cytomegalovirus (CMV) infection who presented with chest pain, polyarthritis, pancytopenia, and renal dysfunction. A serum sample using polymerase chain reaction showed a parvovirus titer of 13.8 trillion IU/mL and a CMV titer of 800 IU/mL. The renal biopsy revealed nucleomegaly with focal viral inclusions, along with changes associated with immunotherapy toxicity. Electron microscopy demonstrated capillary and tubular epithelial cells with “viral factories,” thereby confirming the diagnosis. Thus, screening for parvovirus B19 is advised in high-risk patients who present with refractory anemia to avoid the complications of a chronic infection associated with the fatal rejection of the transplanted organ.

Critical cardiac tamponade in newborn, life-saving emergency interventions and possibility of parvovirus B19 congenital infection

Open Medicine ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. 420-423
Author(s):  
Radoslaw Jaworski ◽  
Ireneusz Haponiuk ◽  
Ninela Irga-Jaworska ◽  
Jolanta Zablocka ◽  
Maciej Chojnicki ◽  
...  
Keyword(s):  
Pericardial Effusion ◽  
Cardiac Tamponade ◽  
Poor Prognosis ◽  
Parvovirus B19 ◽  
Congenital Infection ◽  
Human Parvovirus B19 ◽  
Fetal Exposure ◽  
Life Saving ◽  
Emergency Interventions ◽  
Parvovirus B19 Infection

AbstractThe presence of pericardial effusion in neonates usually indicates a poor prognosis. Here, we report a case of isolation of cardiac tamponade in a newly born. This may be related to vertical human parvovirus B19, an infection with atypical clinical manifestation. Any neonate with unexplained fetal pericardial effusion should always be tested for parvovirus B19 infection, even in the absence of known and proved fetal exposure. Despite the etiology of a tamponade the only reasonable procedure is a surgical evacuation during diagnosis.

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