Sickle Cell Nephropathy
Sickle cell Disease (SCD) is the commonest and most serious inherited anemia in the world and its burden is expected to markedly increase in the next decades. Kidney disease (SCN) is one of the most frequent and severe complications of SCD having a high impact on SCD patient survival and quality of life. SCN phenotypic expression is very heterogeneous and standard markers of kidney damage may not be useful for the early detection of sickle cell disease. Tubular creatinine hypersecretion may mask significant renal impairment before serum creatinine rises, also proteinuria and Hypertension are late markers of irreversible CKD. Treatment with hidroxyurea with broader criteria of SCD patients and SCN screening with early referral to a specialist are needed to improve their survival and quality of life.