Biomarkers Predicting Antidepressant Treatment Response

Depression ◽  
2019 ◽  
pp. 62-86
Author(s):  
Bharathi S. Gadad ◽  
Manish K. Jha ◽  
Madhukar H. Trivedi

In clinical practice, patients do not always experience symptomatic remission or treatment response, even after trying various types of antidepressant medications. To improve outcomes and reduce attrition and nonadherence, there is a great need for personalized treatment of major depression. Hence, recent research efforts have focused on the identification of biological markers (or biomarkers) that can predict whether an individual patient will respond to the commonly used antidepressants. In this chapter, we review the biomarkers associated with antidepressant treatment response with particular attention to genetic, proteomic, metabolomic, transcriptomic, epigenetic biological, and biochemical markers. Although the “omics” approach holds great promise for the future, challenges and roadblocks for future research will need to be addressed.

Depression ◽  
2019 ◽  
pp. 345-356
Author(s):  
Chad D. Rethorst

Beginning with epidemiological evidence and moving to randomized controlled trials, researchers have established evidence supporting the effectiveness of exercise in the treatment of depression. This chapter will provide an overview of the benefits of exercise for patients with depression, discuss the challenges clinicians face in using exercise as a treatment in clinical practice, and provide practical advice on exercise prescription. The chapter concludes with a discussion of areas of need for future research, focusing on three areas: identifying strategies to ensure patient adherence with exercise prescriptions, identifying predictors of treatment response that will facilitate a personalized medicine approach to exercise prescription, and the use of exercise as a complementary agent with other depression treatments.


2018 ◽  
Vol 233 ◽  
pp. 3-14 ◽  
Author(s):  
Bharathi S. Gadad ◽  
Manish K. Jha ◽  
Andrew Czysz ◽  
Jennifer L. Furman ◽  
Taryn L. Mayes ◽  
...  

Author(s):  
Peter Zill ◽  
Thomas C. Baghai ◽  
Rolf Engel ◽  
Peter Zwanzger ◽  
Cornelius Schüle ◽  
...  

2010 ◽  
Vol 79 (2) ◽  
pp. 116-122 ◽  
Author(s):  
Lena C. Quilty ◽  
Kathryn M. Godfrey ◽  
Sidney H. Kennedy ◽  
R. Michael Bagby

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