Peripheral Nerve Sheath Tumors

Nerve sheath tumors involve the connective tissue surrounding a peripheral nerve. They may be found incidentally or may be symptomatic. In most cases, nerve sheath tumors are benign. A detailed personal and family history and careful physical examination should be performed to assess for association with neurofibromatosis 1 or 2 or schwannomatosis. This chapter reviews the genetics, clinical features, diagnosis, and management of the common types of peripheral nerve sheath tumors.