Proof of concept

Mapping Intimacies ◽

10.1093/med/9780198834359.003.0048 ◽

2018 ◽

Author(s):

Victoria Tidman

Keyword(s):

Chronic Pain ◽

Opioid Receptors ◽

Epidural Morphine ◽

Direct Action ◽

Case Series ◽

Substantia Gelatinosa ◽

Proof Of Concept ◽

Small Case Series ◽

The Way

The landmark paper discussed in this chapter is ‘Epidural morphine in treatment of pain’, published by Behar et al. in 1979. A small case series in the seventies first highlighted the use of epidural morphine for pain. It consists of only ten patients who were all administered 2 mg of morphine epidurally. Patients suffering from both acute and chronic pain had a significant reduction in the level of pain within 2–3 minutes, and this lasted 6–24 hours. The authors went on to postulate that morphine produced its effect by a direct action on the specific opioid receptors in the substantia gelatinosa. Although morphine is rarely used epidurally, this paper paved the way for the use of epidural opioids in many different pain conditions.

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Ketogenic Diet Therapy for Intractable Epilepsy in Infantile Alexander Disease: A Small Case Series and Analyses of Astroglial Chemokines and Proinflammatory Cytokines

Epilepsy Research ◽

10.1016/j.eplepsyres.2020.106519 ◽

2021 ◽

Vol 170 ◽

pp. 106519

Author(s):

Shu Hamada ◽

Takeo Kato ◽

Kengo Kora ◽

Tatsuya Kawaguchi ◽

Tenshin Okubo ◽

...

Keyword(s):

Ketogenic Diet ◽

Proinflammatory Cytokines ◽

Case Series ◽

Intractable Epilepsy ◽

Diet Therapy ◽

Alexander Disease ◽

Small Case Series

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Challenges in Evaluation and Management of Children with Myocardial Bridging

Cardiology ◽

10.1159/000513900 ◽

2021 ◽

pp. 1-8

Author(s):

Nurdan Erol

Keyword(s):

Congenital Anomaly ◽

Coronary Artery ◽

Case Reports ◽

Case Series ◽

Diagnosis And Treatment ◽

Myocardial Bridging ◽

Small Case Series ◽

Adults And Children ◽

Artery Branch

Myocardial bridging (MB) is a congenital anomaly where a coronary artery branch or group of branches extends inside a tunnel consisting of myocardium. Although it is mostly considered “benign,” it is reported that MB may lead to significant cardiac problems and sudden cardiac deaths. While it is a congenital anomaly, its symptoms usually arise at further ages rather than childhood. The literature on MB in children is in the form of case reports or small case series. This is why pediatric cases are assessed in the light of information obtained from adults. This review compiled the literature on MB in adults and children and compared it, as well as discussing questions arising regarding the clinic, diagnosis, and treatment of MB.

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Neuroendocrine carcinomas of the head and neck: A small case series

American Journal of Otolaryngology ◽

10.1016/j.amjoto.2021.102992 ◽

2021 ◽

Vol 42 (4) ◽

pp. 102992

Author(s):

Margaret B. Mitchell ◽

Kyle Kimura ◽

Nikita Chapurin ◽

Mario Saab-Chaloub ◽

Mitra Mehrad ◽

...

Keyword(s):

Head And Neck ◽

Case Series ◽

Small Case Series ◽

Neuroendocrine Carcinomas

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The relationship of nystagmus waveform on the VEP response in infantile nystagmus syndrome: a small case series

Documenta Ophthalmologica ◽

10.1007/s10633-016-9568-4 ◽

2017 ◽

Vol 134 (1) ◽

pp. 37-44 ◽

Cited By ~ 1

Author(s):

John P. Kelly ◽

James O. Phillips ◽

Avery H. Weiss

Keyword(s):

Case Series ◽

Infantile Nystagmus Syndrome ◽

Small Case Series ◽

Infantile Nystagmus ◽

Relationship Of ◽

The Relationship

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Cannabis for Chronic Pain: Case Series and Implications for Clinicians

Pain Research and Management ◽

10.1155/2002/380509 ◽

2002 ◽

Vol 7 (2) ◽

pp. 95-99 ◽

Cited By ~ 15

Author(s):

Mark A Ware ◽

Ann Gamsa ◽

Jan Persson ◽

Mary-Ann Fitzcharles

Keyword(s):

Chronic Pain ◽

Health Centre ◽

Case Series ◽

Cannabis Use ◽

Median Frequency ◽

Median Dose ◽

Night Time ◽

Day Range ◽

Frequency Of Use ◽

Mcgill University

BACKGROUND:Chronic pain is one of the most common reasons for therapeutic cannabis use.OBJECTIVES:To describe therapeutic cannabis use among patients with chronic pain.METHODS:Patients with chronic pain who voluntarily indicated that they used cannabis therapeutically completed a questionnaire about the type of cannabis used, the mode of administration, the amount used and the frequency of use, and their perception of the effectiveness of cannabis on a set of pain-associated symptoms and side effects. The study was approved by the McGill University Health Centre Research Ethics Board.RESULTS:Fifteen patients (10 male) were interviewed (median age 49.5 years, range 24 to 68 years). All patients smoked herbal cannabis for therapeutic reasons (median duration of use six years, range two weeks to 37 years). Seven patients only smoked at night-time (median dose eight puffs, range two to eight puffs), and eight patients used cannabis mainly during the day (median dose three puffs, range two to eight puffs); the median frequency of use was four times per day (range one to 16 times per day). Twelve patients reported improvement in pain and mood, while 11 reported improvement in sleep. Eight patients reported a 'high'; six denied a 'high'. Tolerance to cannabis was not reported.CONCLUSIONS:The results of this self-selected case series must be interpreted with caution. Small doses of smoked cannabis may improve pain, mood and sleep in some patients with chronic pain. Clinical trials are warranted to test these effects. Further prospective studies should examine the patterns and prevalence of cannabis use among chronic pain populations.

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