Heart valve disease

2010 ◽  
pp. 2736-2757
Author(s):  
Michael Henein
Keyword(s):  
Developing Countries ◽  
North America ◽  
Heart Valve ◽  
Valve Disease ◽  
Heart Valve Disease ◽  
Northern Europe ◽  
Diagnostic Investigation ◽  
Rheumatic Valve Disease ◽  
Valve Pathology

Rheumatic valve disease remains prevalent in developing countries, but over the last 50 years there has been a decline in the incidence of rheumatic valve disease and an increase in the prevalence of degenerative valve pathology in northern Europe and North America. In all forms of valve disease, the most appropriate initial diagnostic investigation is almost always the echocardiogram....

scholarly journals P24: MANAGEMENT OF RHEUMATIC VALVE DISEASE OF THE AORTIC VALVE USING THE OZAKI PROCEDURE WITH AUTOLOGOUS PERICARDIUM

2021 ◽  
Vol 108 (Supplement_1) ◽  
Author(s):  
A Asif ◽  
M Caputo
Keyword(s):  
Aortic Valve ◽  
Intraoperative Complications ◽  
Valve Disease ◽  
Severe Aortic Regurgitation ◽  
Autologous Pericardium ◽  
End Diastolic Volume ◽  
Rheumatic Valve Disease ◽  
Coronary Cusp ◽  
Valve Pathology ◽  
Diastolic Murmur

Abstract Case-Study A 15-year-old boy was referred to our tertiary centre from his local paediatric services with a background of rheumatic fever, severe aortic regurgitation (AR) and mild to moderate mitral regurgitation. He had a history of angina and dyspnoea on exertion, a 2/6 ejection systolic murmur and 2/4 end diastolic murmur. Transthoracic echocardiography showed severe aortic valve insufficiency (with flow reversal seen in the descending aorta and an LV end diastolic volume of 173 ml/m2) and trivial pulmonary valve regurgitation. Autograft failure following the favoured Ross procedure deemed the patient as a candidate for an Ozaki procedure. Autologous pericardium was used to replace the diseased aortic valve. Intraoperative transoesophageal echocardiography showed a deficient left coronary cusp leaflet and a retracted right coronary cusp leaflet. The patient was under cardiopulmonary bypass for 124 minutes and on cross-clamping for 99 minutes with no intraoperative complications. Histological examination of the aortic valve leaflets showed neovascularisation, myxoid changes and disarray of the fibrous stroma. Postoperative recovery was uneventful. The postoperative echocardiogram showed trivial AR, end diastolic volume 217ml, end systolic volume 12 ml and 40% ejection fraction. There was full resolution of the dyspnoea, angina and diastolic murmur on follow-up 4-months postoperatively as supported by healthy valve function on echocardiography. This case highlights that in those of risk of multiple valve pathology, such as in rheumatic valve disease, an Ozaki procedure using autologous pericardium is a viable surgical option for paediatric aortic valve repair with good outcomes. Take-home message In cases of systemic conditions affecting the heart valves where there is multiple valve pathology and risk of autograft failure, such as rheumatic valve disease, the use of autologous pericardium to replace these valves has shown to be a viable option in this paediatric case.

Evaluation of Patients with Heart Valve Disease

2019 ◽  
pp. 9-19
Author(s):  
Jose Zamorano ◽  
Ciro Santoro ◽  
Álvaro Marco del Castillo
Keyword(s):  
Heart Valve ◽  
Valve Disease ◽  
Heart Valve Disease

scholarly journals Inflammatory Regulation of Valvular Remodeling: The Good(?), the Bad, and the Ugly

2011 ◽  
Vol 2011 ◽  
pp. 1-13 ◽  
Author(s):  
Gretchen J. Mahler ◽  
Jonathan T. Butcher
Keyword(s):  
Heart Valve ◽  
Cell Biology ◽  
Heart Valves ◽  
Valve Disease ◽  
Heart Valve Disease ◽  
Inflammatory Signaling ◽  
Current State ◽  
Valve Remodeling ◽  
Inflammatory Regulation ◽  
Key Questions

Heart valve disease is unique in that it affects both the very young and very old, and does not discriminate by financial affluence, social stratus, or global location. Research over the past decade has transformed our understanding of heart valve cell biology, yet still more remains unclear regarding how these cells respond and adapt to their local microenvironment. Recent studies have identified inflammatory signaling at nearly every point in the life cycle of heart valves, yet its role at each stage is unclear. While the vast majority of evidence points to inflammation as mediating pathological valve remodeling and eventual destruction, some studies suggest inflammation may provide key signals guiding transient adaptive remodeling. Though the mechanisms are far from clear, inflammatory signaling may be a previously unrecognized ally in the quest for controlled rapid tissue remodeling, a key requirement for regenerative medicine approaches for heart valve disease. This paper summarizes the current state of knowledge regarding inflammatory mediation of heart valve remodeling and suggests key questions moving forward.

scholarly journals Perioperative Management of Sectio Caesarea Surgery in Patient With Heart Valve Disorders

2021 ◽  
Vol 1 (1) ◽  
pp. 1
Author(s):  
Purwoko Purwoko ◽  
Zidni Afrokhul Athir
Keyword(s):  
Mitral Regurgitation ◽  
Cesarean Section ◽  
Maternal Mortality ◽  
Pulmonary Edema ◽  
Heart Valve ◽  
Mitral Stenosis ◽  
Valve Disease ◽  
Heart Valve Disease ◽  
Normal Limits ◽  
In Pregnancy

<div class="WordSection1"><p>Cardiovascular disease in pregnancy is common range from 1% to 3 and contributes to 10-15% of maternal mortality. Valvular heart disease accounts for about 25% of cases of cardiac complications in pregnancy and important cause of maternal mortality, some of which are mitral stenosis and mitral regurgitation. Cesarean delivery remains the preferred choice, as it reduces the hemodynamic changes that can occur in normal delivery and allows for better monitoring and hemodynamic management. Our paper provide in-depth information regarding the pathophysiology of heart valve disease in pregnant women and an appropriate perianesthesia approach to obtain a good prognosis. We report a case of a 26-year-old pregnant woman, with obstetric status G1P0A0, 36 weeks’ gestation, body weight 61 kg accompanied by severe mitral regurgitation and moderate mitral stenosis. This patient was planned to undergo elective cesarean section. The patient's condition in the perioperative examination was: GCS E4V5M6, other vital signs within normal limits, SpO2 98-99% in supine position. Other physical and laboratory examinations were also within normal limits. The goal of anesthesia during surgery in patients with heart valve disease undergoing cesarean section maintain pulmonary capillary pressure to prevent acute pulmonary edema. In this case, regional anesthesia of epidural anesthesia was chosen because it can reduce systemic vascular resistance and provide better post-cesarean section pain. The patient's hemodynamics perianesthesia tended to be stable without any complications such as pulmonary edema.</p><p> </p><p> </p></div><br clear="all" /> <br /><p> </p>

Deregulation of TNF expression can also cause heart valve disease

Cytokine ◽  
2016 ◽  
Vol 77 ◽  
pp. 248-249 ◽  
Author(s):  
Derek Lacey ◽  
Philippe Bouillet
Keyword(s):  
Heart Valve ◽  
Valve Disease ◽  
Heart Valve Disease

Association of antibodies against phospholipids with heart valve disease in systemic lupus erythematosus

The Lancet ◽  
1990 ◽  
Vol 335 (8705) ◽  
pp. 1541-1544 ◽  
Author(s):  
M.A. Khamashta ◽  
R. Cervera ◽  
R.A. Asherson ◽  
G.R.V. Hughes ◽  
D.J. Coltart ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Heart Valve ◽  
Lupus Erythematosus ◽  
Valve Disease ◽  
Heart Valve Disease ◽  
Systemic Lupus

scholarly journals Heart valve disease in general practice: a clinical overview

2015 ◽  
Vol 65 (632) ◽  
pp. e204-e206 ◽  
Author(s):  
Jessica Webb ◽  
Chris Arden ◽  
John B Chambers
Keyword(s):  
General Practice ◽  
Heart Valve ◽  
Valve Disease ◽  
Heart Valve Disease ◽  
Clinical Overview
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