Head & neck cancer
The head and neck region encompasses anatomical sites below the brain and above the clavicles, excluding skin and thyroid. The sites most commonly involved with cancer are the oral cavity, larynx, and pharynx. Overall 5-year survival rates for head and neck cancer have improved only slightly over the past two decades remaining at just over 50%. This figure in part reflects the population who present with this disease in terms of age and comorbidity (typically about 15% intercurrent death rates at 5 years), as well as the tendency to develop second primaries and metastases. The poor long-term survival rates may also reflect the fact that 60% of patients with head and neck cancer have advanced disease at the time of presentation (stage III/IV disease). The dominant treatment failure in head and neck cancer is locoregional relapse and this remains the main focus for clinicians involved in the management of these patients....