Sexual Dysfunction

Concussion Care Manual ◽

10.1093/med/9780199383863.003.0023 ◽

2014 ◽

pp. 97-98

Author(s):

David L Brody

Keyword(s):

Spinal Cord ◽

Spinal Cord Injury ◽

Drug Abuse ◽

Side Effects ◽

Sexual Dysfunction ◽

Pde5 Inhibitor ◽

Cauda Equina ◽

Sexual Side Effects ◽

Severe Fatigue ◽

Cord Injury

This chapter addresses issues surrounding sexual dysfunction after concussion. Ask the patient specifically about sexual dysfunction in private, and if appropriate ask the collateral source separately. Assess for depression, severe fatigue or hypersomnia, untreated pain, and alcohol or drug abuse (especially marijuana). Check medications for sexual side effects; serotonin specific reuptake inhibitors are the most common culprits. Test for hormonal imbalances and unrecognized cauda equina or lower spinal cord injury. Consider a trial of a PDE5 inhibitor and refer to urology for more advanced options.

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Sexual Dysfunction

Concussion Care Manual ◽

10.1093/med/9780190054793.003.0024 ◽

2019 ◽

pp. 143-145

Author(s):

David L. Brody

Keyword(s):

Spinal Cord ◽

Spinal Cord Injury ◽

Side Effects ◽

Sexual Dysfunction ◽

Pde5 Inhibitor ◽

Cauda Equina ◽

Sexual Side Effects ◽

Severe Fatigue ◽

Cord Injury ◽

Phosphodiesterase Type

In private, ask specifically about sexual dysfunction, and if appropriate, ask the collateral source separately. Assess for depression, severe fatigue or hypersomnia, untreated pain, and alcohol or drug abuse (especially marijuana). Check medications for sexual side effects; serotonin specific reuptake inhibitors are the most common culprits. Test for hormonal imbalances and unrecognized cauda equina or lower spinal cord injury. Consider a trial of a phosphodiesterase type 5 (PDE5) inhibitor, and refer to urology for more advanced options.

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Polyphenols as Potential Therapeutics for Pain and Inflammation in Spinal Cord Injury

Current Molecular Pharmacology ◽

10.2174/1874467213666201223111743 ◽

2020 ◽

Vol 13 ◽

Author(s):

Ashif Iqubal ◽

Musheer Ahmed ◽

Mohammad Kashif Iqubal ◽

Faheem Hyder Pottoo ◽

Syed Ehtaishamul Haque

Keyword(s):

Spinal Cord ◽

Spinal Cord Injury ◽

Side Effects ◽

Transient Receptor Potential ◽

Receptor Potential ◽

Neutrophil Infiltration ◽

Matrix Metal ◽

Mediators Of Inflammation ◽

Major Player ◽

Cord Injury

: Spinal cord injury (SCI) and associated pain and inflammation caused by the trauma or infection is one of the serious health care issues world-wide. The various inflammatory, redox-sensitive and apoptotic events are contributing factor but altered neuronal function, axonal degeneration, activated microglia, endothelial cells, astrocytes, fibroblasts,pericytes, Schwann cells, meningeal cells are the major player in its pathogenesis. Further, monocytes and neutrophil infiltration get recruited and facilitate the release of chemokines, cytokines, and other mediators of inflammation. This event leads to the production of different amino acids, neuropeptides kinin, prostaglandins, prostacyclin, thromboxane, leukotrienes, bradykinin, histamine, matrix metal proteinases and serotonin that stimulate nerve endings and manifests the inflammation and pain processes, etc. Arachidonic acid (AA), NF-kB, NLRP3 inflammasome, and nitric oxide pathways along with P2X7 receptor and ion channel transient receptor potential (TRP) vanilloid are some of the recently explored targets for modulation of pain and inflammation in SCI. Till now, NSAIDs, opioids, antidepressants, anticonvulsants, NMDA antagonists, α2-adrenergic agonists, and GABA-receptor agonists are used for the management of these pathological conditions. However, these drugs are associated with various side effects. Additionally, the number of available animal models for SCI has enhanced the understanding of the complex pathological mechanisms involved in the generation of chronic inflammatory pain in SCI. These findings enable us to identify and validate several potent natural analgesic-anti-inflammatory drug candidates with minimal side effects. However, until now, these compounds have been studied in preclinical models and shown promising results but no clinical studies have been performed. Therefore, a detailed exploration of these natural compounds is important for bringing them from bench to bedside.

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Pathophysiology of male sexual dysfunction after spinal cord injury

Textbook of the Neurogenic Bladder ◽

10.1201/b18585-65 ◽

2015 ◽

pp. 733-740

Author(s):

Pierre Denys ◽

Clément Chéhensse

Keyword(s):

Spinal Cord ◽

Spinal Cord Injury ◽

Sexual Dysfunction ◽

Cord Injury ◽

Male Sexual Dysfunction

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Titration of serum anti-ganglioside antibodies in patients with chronic medular injury previous to treatment with GM1 ganglioside

Acta Ortopédica Brasileira ◽

10.1590/s1413-78522003000200001 ◽

2003 ◽

Vol 11 (2) ◽

pp. 69-71

Author(s):

Tarcísio Eloy Pessoa Barros Filho ◽

Ciro da Silva Filho

Keyword(s):

Spinal Cord ◽

Spinal Cord Injury ◽

Side Effects ◽

Spinal Cord Lesion ◽

Gm1 Ganglioside ◽

Chronic Spinal Cord Injury ◽

Cord Injury ◽

Ganglioside Antibodies ◽

Asialo Gm1 ◽

Cord Lesion

Anti-ganglioside serum titers were evaluated by ELISA in 150 patients with complete spinal cord lesion for 6 to 12 months (IgG monosialo GM1, IgM monosialo GM1, IgG asialo GM1, IgM asialo GM1, IgG disialo GD1b e IgM disialo GD1b) prior to treatment with GM1 100 mg/day i.m. Only 4 patients showed positive titers for anti-asialo-GM1 (IgM) antibodies . All patients were clinically examined during and after treatment. No important side effects were observed with GM1 therapy. These results suggest that GM1-ganglioside administration in patients with chronic spinal cord injury is safe.

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Pathophysiology of male sexual dysfunction after spinal cord injury

Textbook of the Neurogenic Bladder ◽

10.3109/9781439805046-87 ◽

2008 ◽

pp. 895-897

Keyword(s):

Spinal Cord ◽

Spinal Cord Injury ◽

Sexual Dysfunction ◽

Cord Injury ◽

Male Sexual Dysfunction

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HDAC8 Inhibition Reduces Lesional Iba-1+ Cell Infiltration after Spinal Cord Injury without Effects on Functional Recovery

International Journal of Molecular Sciences ◽

10.3390/ijms21124539 ◽

2020 ◽

Vol 21 (12) ◽

pp. 4539

Author(s):

Sven Hendrix ◽

Selien Sanchez ◽

Elissia Ventriglia ◽

Stefanie Lemmens

Keyword(s):

Spinal Cord ◽

Spinal Cord Injury ◽

Valproic Acid ◽

Side Effects ◽

Histone Deacetylase ◽

Functional Recovery ◽

Hdac Inhibition ◽

Beneficial Effects ◽

Cord Injury ◽

Classically Activated

Pan-histone deacetylase (HDAC) inhibition with valproic acid (VPA) has beneficial effects after spinal cord injury (SCI), although with side effects. We focused on specific HDAC8 inhibition, because it is known to reduce anti-inflammatory mediators produced by macrophages (Mφ). We hypothesized that HDAC8 inhibition improves functional recovery after SCI by reducing pro-inflammatory classically activated Mφ. Specific HDAC8 inhibition with PCI-34051 reduced the numbers of perilesional Mφ as measured by histological analyses, but did not improve functional recovery (Basso Mouse Scale). We could not reproduce the published improvement of functional recovery described in contusion SCI models using VPA in our T-cut hemisection SCI model. The presence of spared fibers might be the underlying reason for the conflicting data in different SCI models.

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