Intraocular tumours

2014 ◽  
pp. 625-650
Author(s):  
Alastair K.O. Denniston ◽  
Philip I. Murray
Keyword(s):  
Retinal Pigment Epithelium ◽  
Clinical Features ◽  
Ciliary Body ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Practical Approach ◽  
Intraocular Tumours

‘Intraocular tumours’ provides the reader with a practical approach to the assessment and management of these diseases. This chapter includes iris tumours, ciliary body tumours, choroidal tumours (including melanoma and haemangioma), retinoblastoma, retinal pigment epithelium tumours and lymphoma. Using a patient-centred approach the key clinical features, investigations and treatment (medical and surgical) are described for each condition.

Intraocular tumours

2018 ◽  
pp. 699-726
Keyword(s):  
Retinal Pigment Epithelium ◽  
Clinical Features ◽  
Ciliary Body ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Practical Approach ◽  
Intraocular Tumours

‘Intraocular tumours’ provides the reader with a practical approach to the assessment and management of these diseases. This chapter includes iris tumours, ciliary body tumours, choroidal tumours (including melanoma and haemangioma), retinoblastoma, retinal pigment epithelium tumours and lymphoma. Using a patient-centred approach the key clinical features, investigations and treatment (medical and surgical) are described for each condition.

Involvement of p27(KIP1) in proliferation of the retinal pigment epithelium and ciliary body

2004 ◽  
Vol 208 (2) ◽  
pp. 145-150 ◽  
Author(s):  
Hiroyasu Nagahama ◽  
Takayuki Harada ◽  
Hiromi Ikeda ◽  
Chikako Harada ◽  
Junko Imaki ◽  
...  
Keyword(s):  
Retinal Pigment Epithelium ◽  
Ciliary Body ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
P27 Kip1

scholarly journals Common clinical features of unilateral retinal pigment epithelium dysgenesis and combined hamartoma of the retina and retinal pigment epithelium

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Zhe Zhu ◽  
Jun Xiao ◽  
Lifu Luo ◽  
Bo Yang ◽  
He Zou ◽  
...  
Keyword(s):  
Retinal Pigment Epithelium ◽  
Clinical Features ◽  
Pigment Epithelium ◽  
Fundus Autofluorescence ◽  
Retinal Pigment ◽  
Chinese Patients ◽  
Fluorescence Angiography ◽  
Case Presentation ◽  
The Relationship

Abstract Background Herein, we report two cases of unilateral retinal pigment epithelium dysgenesis (URPED) in Chinese patients and explore the relationship between URPED and combined hamartoma of the retina and retinal pigment epithelium (CHRRPE). Case presentation The lesion margins in the two cases showed pathognomonic clinical features of URPED, namely, a scalloped reticular margin in hyperplastic retinal pigment epithelium and mild fibrosis. The hypoautofluorescence observed by fundus autofluorescence was inverted compared with that observed by fundus fluorescence angiography. A large amount of fibroglial proliferation and disorganization of the retina involving the whole layer, which are also found in peripapillary CHRRPE, were found in the lesions. Conclusions URPED appears to share some clinical features with CHRRPE, and the relationship between URPED and CHRRPE needs further study.

scholarly journals Defining the proteome of human iris, ciliary body, retinal pigment epithelium, and choroid

PROTEOMICS ◽  
2016 ◽  
Vol 16 (7) ◽  
pp. 1146-1153 ◽  
Author(s):  
Pingbo Zhang ◽  
David Kirby ◽  
Craig Dufresne ◽  
Yan Chen ◽  
Randi Turner ◽  
...  
Keyword(s):  
Retinal Pigment Epithelium ◽  
Ciliary Body ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Human Iris

Chemistry, Distribution, and Metabolism of Tomato Carotenoids and Their Impact on Human Health

2002 ◽  
Vol 227 (10) ◽  
pp. 845-851 ◽  
Author(s):  
Frederick Khachik ◽  
Lorena Carvalho ◽  
Paul S. Bernstein ◽  
Garth J. Muir ◽  
Da-You Zhao ◽  
...  
Keyword(s):  
Retinal Pigment Epithelium ◽  
Human Serum ◽  
Macular Degeneration ◽  
Ciliary Body ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Food Products ◽  
Age Related Macular Degeneration ◽  
Ocular Tissues ◽  
Age Related

Recent epidemiological studies have suggested that the consumption of tomatoes and tomato-based food products reduce the risk of prostate cancer in humans. This protective effect has been attributed to carotenoids, which are one of the major classes of phytochemicals in this fruit. The most abundant carotenoid in tomato is lycopene, followed by phytoene, phytofluene, ζ-carotene, -γ-carotene, ß-carotene, neurosporene, and lutein. The distribution of lycopene and related carotenoids in tomatoes and tomato-based food products has been determined by extraction and high-performance liquid chromatography-UV/Visible photodiode array detection. Detailed qualitative and quantitative analysis of human serum, milk, and organs, particularly prostate, have revealed the presence of all the aforementioned carotenoids in biologically significant concentrations. Two oxidative metabolites of lycopene, 2, 6-cyclolycopene-1, 5-diols A and B, which are only present in tomatoes in extremely low concentrations, have been isolated and identified in human serum, milk, organs (liver, lung, breast, liver, prostate, colon) and skin. Carotenoids may also play an important role in the prevention of age-related macular degeneration, cataracts, and other blinding disorders. Among 25 dietary carotenoids and nine metabolites routinely found in human serum, mainly (3R, 3'R, 6'R)-lutein, (3R, 3'R)-zeaxanthin, lycopene, and their metabolites were detected in ocular tissues. In this review we identified and quantified the complete spectrum of carotenoids from pooled human retinal pigment epithelium, ciliary body, iris, lens, and in the uveal tract and in other tissues of the human eye to gain a better insight into the metabolic pathways of ocular carotenoids. Although (3R, 3'R, 6'R)-lutein, (3R, 3'R)-zeaxanthin, and their metabolites constitute the major carotenoids in human ocular tissues, lycopene and a wide range of dietary carotenoids have been detected in high concentrations in ciliary body and retinal pigment epithelium. The possible role of lycopene and other dietary carotenoids in the prevention of age-related macular degeneration and other eye diseases Is discussed.

scholarly journals Clinical features of cases with retinal pigment epithelium aperture

2021 ◽  
Vol 22 ◽  
pp. 101083
Author(s):  
Akie Yoshinaga ◽  
Kohei Ueda ◽  
Ryo Terao ◽  
Keiko Azuma ◽  
Tatsuya Inoue ◽  
...  
Keyword(s):  
Retinal Pigment Epithelium ◽  
Clinical Features ◽  
Pigment Epithelium ◽  
Retinal Pigment

High-voltage electron microscopy of subretinal scar formation

1992 ◽  
Vol 50 (1) ◽  
pp. 486-487
Author(s):  
G.E. Korte ◽  
M. Marko ◽  
G. Hageman
Keyword(s):  
Electron Microscopy ◽  
Monoclonal Antibody ◽  
Retinal Pigment Epithelium ◽  
Glial Cells ◽  
High Voltage ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Sodium Iodate ◽  
High Voltage Electron Microscopy ◽  
Voltage Electron

Sodium iodate iv. damages the retinal pigment epithelium (RPE) in rabbits. Where RPE does not regenerate (e.g., 1,2) Muller glial cells (MC) forma subretinal scar that replaces RPE. The MC response was studied by HVEM in 3D computer reconstructions of serial thick sections, made using the STEREC0N program (3), and the HVEM at the NYS Dept. of Health in Albany, NY. Tissue was processed for HVEM or immunofluorescence localization of a monoclonal antibody recognizing MG microvilli (4).

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