scholarly journals Protein Domains Involved in Assembly in the Endoplasmic Reticulum Promote Vacuolar Delivery when Fused to Secretory GFP, Indicating a Protein Quality Control Pathway for Degradation in the Plant Vacuole

2008 ◽  
Vol 1 (6) ◽  
pp. 1067-1076 ◽  
Author(s):  
Ombretta Foresti ◽  
Francesca De Marchis ◽  
Maddalena de Virgilio ◽  
Eva M. Klein ◽  
Sergio Arcioni ◽  
...  
Keyword(s):  
Quality Control ◽  
Endoplasmic Reticulum ◽  
Protein Quality ◽  
Protein Domains ◽  
Protein Quality Control ◽  
Plant Vacuole

The endoplasmic reticulum: A hub of protein quality control in health and disease

2017 ◽  
Vol 108 ◽  
pp. 383-393 ◽  
Author(s):  
Lisa Vincenz-Donnelly ◽  
Mark S. Hipp
Keyword(s):  
Quality Control ◽  
Endoplasmic Reticulum ◽  
Protein Quality ◽  
Protein Quality Control ◽  
Health And Disease

Endoplasmic Reticulum Protein Quality Control and Degradation

2008 ◽  
pp. 123-143
Author(s):  
Antje Schfer ◽  
Zlatka Kostova ◽  
Dieter H. Wolf
Keyword(s):  
Quality Control ◽  
Endoplasmic Reticulum ◽  
Protein Quality ◽  
Protein Quality Control ◽  
Endoplasmic Reticulum Protein

scholarly journals Protein quality control through endoplasmic reticulum-associated degradation maintains haematopoietic stem cell identity and niche interactions

2020 ◽  
Vol 22 (10) ◽  
pp. 1162-1169 ◽  
Author(s):  
Longyong Xu ◽  
Xia Liu ◽  
Fanglue Peng ◽  
Weijie Zhang ◽  
Liting Zheng ◽  
...  
Keyword(s):  
Quality Control ◽  
Endoplasmic Reticulum ◽  
Stem Cell ◽  
Protein Quality ◽  
Protein Quality Control ◽  
Haematopoietic Stem Cell ◽  
Cell Identity ◽  
Endoplasmic Reticulum Associated Degradation

scholarly journals Characterization of an ERAD Gene as VPS30/ATG6 Reveals Two Alternative and Functionally Distinct Protein Quality Control Pathways: One for Soluble Z Variant of Human α-1 Proteinase Inhibitor (A1PiZ) and Another for Aggregates of A1PiZ

2006 ◽  
Vol 17 (1) ◽  
pp. 203-212 ◽  
Author(s):  
Kristina B. Kruse ◽  
Jeffrey L. Brodsky ◽  
Ardythe A. McCracken
Keyword(s):  
Quality Control ◽  
Endoplasmic Reticulum ◽  
Proteinase Inhibitor ◽  
Protein Quality ◽  
Protein Quality Control ◽  
Carboxypeptidase Y ◽  
Complex Nature ◽  
Secretion Pathway ◽  
Golgi Network ◽  
Yeast Mutants

The Z variant of human α-1 proteinase inhibitor (A1PiZ) is a substrate for endoplasmic reticulum-associated protein degradation (ERAD). To identify genes required for the degradation of this protein, A1PiZ degradation-deficient (add) yeast mutants were isolated. The defect in one of these mutants, add3, was complemented by VPS30/ATG6, a gene that encodes a component of two phosphatidylinositol 3-kinase (PtdIns 3-kinase) complexes: complex I is required for autophagy, whereas complex II is required for the carboxypeptidase Y (CPY)-to-vacuole pathway. We found that upon overexpression of A1PiZ, both PtdIns 3-kinase complexes were required for delivery of the excess A1PiZ to the vacuole. When the CPY-to-vacuole pathway was compromised, A1PiZ was secreted; however, disruption of autophagy led to an increase in aggregated A1PiZ rather than secretion. These results suggest that excess soluble A1PiZ transits the secretion pathway to the trans-Golgi network and is selectively targeted to the vacuole via the CPY-to-vacuole sorting pathway, but excess A1PiZ that forms aggregates in the endoplasmic reticulum is targeted to the vacuole via autophagy. These findings illustrate the complex nature of protein quality control in the secretion pathway and reveal multiple sites that recognize and sort both soluble and aggregated forms of aberrant or misfolded proteins.

Protein Quality Control, Retention, and Degradation at the Endoplasmic Reticulum

2011 ◽  
pp. 197-280 ◽  
Author(s):  
Ron Benyair ◽  
Efrat Ron ◽  
Gerardo Z. Lederkremer
Keyword(s):  
Quality Control ◽  
Endoplasmic Reticulum ◽  
Protein Quality ◽  
Protein Quality Control

Endoplasmic Reticulum-Associated Degradation and Protein Quality Control

2016 ◽  
pp. 596-611 ◽  
Author(s):  
L.F. Zacchi ◽  
J.J. Caramelo ◽  
A.A. McCracken ◽  
J.L. Brodsky
Keyword(s):  
Quality Control ◽  
Endoplasmic Reticulum ◽  
Protein Quality ◽  
Protein Quality Control ◽  
Endoplasmic Reticulum Associated Degradation

scholarly journals Endoplasmic reticulum stress differentially inhibits endoplasmic reticulum and inner nuclear membrane protein quality control degradation pathways

2019 ◽  
Vol 294 (51) ◽  
pp. 19814-19830 ◽  
Author(s):  
Bryce W. Buchanan ◽  
Adrian B. Mehrtash ◽  
Courtney L. Broshar ◽  
Avery M. Runnebohm ◽  
Brian J. Snow ◽  
...  
Keyword(s):  
Quality Control ◽  
Endoplasmic Reticulum ◽  
Membrane Protein ◽  
Endoplasmic Reticulum Stress ◽  
Nuclear Membrane ◽  
Protein Quality ◽  
Protein Quality Control ◽  
Degradation Pathways ◽  
Inner Nuclear Membrane ◽  
Inner Nuclear Membrane Protein
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