scholarly journals The encapsidation signal on the hepatitis B virus RNA pregenome forms a stem-loop structure that is critical for its function

1993 ◽  
Vol 21 (17) ◽  
pp. 3967-3975 ◽  
Author(s):  
Thomas Knaus ◽  
Michael Nassal
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Loop Structure ◽  
Stem Loop ◽  
Stem Loop Structure ◽  
Virus Rna ◽  
Encapsidation Signal ◽  
B Virus

scholarly journals La Autoantigen Specifically Recognizes a Predicted Stem-Loop in Hepatitis B Virus RNA

1999 ◽  
Vol 73 (7) ◽  
pp. 5767-5776 ◽  
Author(s):  
Tilman Heise ◽  
Luca G. Guidotti ◽  
Francis V. Chisari
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Rna Stability ◽  
Dependent Manner ◽  
Necrosis Factor Alpha ◽  
Stem Loop ◽  
Stem Loop Structure ◽  
La Protein ◽  
Virus Rna ◽  
B Virus

ABSTRACT We recently identified three nuclear proteins (p45, p39, and p26) that bind to a 91-nucleotide (nt) RNA element between nt 1243 and 1333 in hepatitis B virus (HBV) RNA, and we showed that these proteins and HBV RNA are regulated coordinately by gamma interferon and tumor necrosis factor alpha. Purification and sequence analysis of tryptic peptides obtained from p39 revealed sequence homology to the mouse La protein. Immunoprecipitation experiments showed that p45, p39, and p26 were recognized by anti-La-specific antiserum, indicating that p45 is the full-length La protein and that p39 and p26 are likely to be proteolytic La cleavage products. Furthermore, in competition experiments we found that all three La proteins bind, in a phosphorylation-dependent manner, to the same predicted stem-loop structure located between nt 1275 and 1291 of HBV, withKd s of approximately 1.0 nM. Collectively, these results support the notion that the La protein may contribute to HBV RNA stability, constitutively and in response to inflammatory cytokines.

scholarly journals Solution structure of the apical stem–loop of the human hepatitis B virus encapsidation signal

2006 ◽  
Vol 34 (16) ◽  
pp. 4449-4457 ◽  
Author(s):  
Sara Flodell ◽  
Michael Petersen ◽  
Frederic Girard ◽  
Janusz Zdunek ◽  
Karin Kidd-Ljunggren ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Solution Structure ◽  
Stem Loop ◽  
Human Hepatitis ◽  
Encapsidation Signal ◽  
B Virus

Host cell proteins binding to the encapsidation signal in hepatitis B virus RNA

2002 ◽  
Vol 147 (3) ◽  
pp. 471-491 ◽  
Author(s):  
H. J. Shin ◽  
S. S. Kim ◽  
Y. H. Cho ◽  
S. G. Lee ◽  
H. M. Rho
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Host Cell ◽  
Host Cell Proteins ◽  
Virus Rna ◽  
Encapsidation Signal ◽  
B Virus

scholarly journals A SELEX-Screened Aptamer of Human Hepatitis B Virus RNA Encapsidation Signal Suppresses Viral Replication

PLoS ONE ◽  
2011 ◽  
Vol 6 (11) ◽  
pp. e27862 ◽  
Author(s):  
Hui Feng ◽  
Jürgen Beck ◽  
Michael Nassal ◽  
Kang-hong Hu
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Viral Replication ◽  
Human Hepatitis ◽  
Virus Rna ◽  
Encapsidation Signal ◽  
B Virus
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