scholarly journals The molecular mechanism of DNA damage recognition by MutS homologs and its consequences for cell death response

2006 ◽  
Vol 34 (8) ◽  
pp. 2173-2185 ◽  
Author(s):  
F. R. Salsbury
Keyword(s):  
Dna Damage ◽  
Cell Death ◽  
Molecular Mechanism ◽  
Damage Recognition ◽  
Cell Death Response ◽  
Dna Damage Recognition

scholarly journals Targeting Protein-Protein Interactions in the DNA Damage Response Pathways for Cancer Chemotherapy

2021 ◽  
Author(s):  
Kerry Silva McPherson ◽  
Dmitry Korzhnev
Keyword(s):  
Dna Damage ◽  
Dna Damage Response ◽  
Protein Interactions ◽  
Cell Cycle Progression ◽  
Protein Protein Interactions ◽  
Cycle Progression ◽  
Damage Recognition ◽  
Damage Response ◽  
Cellular Dna ◽  
Dna Damage Recognition

Cellular DNA damage response (DDR) is an extensive signaling network that orchestrates DNA damage recognition, repair and avoidance, cell cycle progression and cell death. DDR alternation is a hallmark of...

scholarly journals SETD2 alterations impair DNA damage recognition and lead to resistance to chemotherapy in leukemia

Blood ◽  
2017 ◽  
Vol 130 (24) ◽  
pp. 2631-2641 ◽  
Author(s):  
Brenton G. Mar ◽  
S. Haihua Chu ◽  
Josephine D. Kahn ◽  
Andrei V. Krivtsov ◽  
Richard Koche ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Damage Response ◽  
Mutation Rate ◽  
Histone 3 ◽  
Damage Recognition ◽  
Key Points ◽  
Damage Response ◽  
Dna Damage Recognition ◽  
Resistance To Chemotherapy

Key Points Alterations of SETD2, a histone 3 lysine 36 trimethyl (H3K36me3) transferase leads to resistance to DNA damaging-chemotherapy in leukemia. Low H3K36me3 levels impair DNA damage response and increase mutation rate, which may be targeted by H3K36me3 demethylase inhibition.

The role of chromatin proteins in DNA damage recognition and repair Mini-review

2005 ◽  
Vol 125 (1-2) ◽  
pp. 119-126 ◽  
Author(s):  
Piotr Widlak ◽  
Monika Pietrowska ◽  
Joanna Lanuszewska
Keyword(s):  
Dna Damage ◽  
Damage Recognition ◽  
Chromatin Proteins ◽  
Dna Damage Recognition
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