scholarly journals Hypertension, cerebral oedema and fundoscopy

2003 ◽  
Vol 18 (11) ◽  
pp. 2424-2427 ◽  
Author(s):  
R. C. Bakker
Keyword(s):  
Cerebral Oedema

scholarly journals R1352Q CACNA1A Variant in a Patient with Sporadic Hemiplegic Migraine, Ataxia, Seizures and Cerebral Oedema: A Case Report

2021 ◽  
pp. 123-130
Author(s):  
Anker Stubberud ◽  
Emer O’Connor ◽  
Erling Tronvik ◽  
Henry Houlden ◽  
Manjit Matharu
Keyword(s):  
Mental Retardation ◽  
Case Report ◽  
Genetic Testing ◽  
Head Trauma ◽  
Cerebral Oedema ◽  
De Novo ◽  
Minor Head Trauma ◽  
Hemiplegic Migraine ◽  
Wide Range ◽  
History Of

Mutations in the <i>CACNA1A</i> gene show a wide range of neurological phenotypes including hemiplegic migraine, ataxia, mental retardation and epilepsy. In some cases, hemiplegic migraine attacks can be triggered by minor head trauma and culminate in encephalopathy and cerebral oedema. A 37-year-old male without a family history of complex migraine experienced hemiplegic migraine attacks from childhood. The attacks were usually triggered by minor head trauma, and on several occasions complicated with encephalopathy and cerebral oedema. Genetic testing of the proband and unaffected parents revealed a de novo heterozygous nucleotide missense mutation in exon 25 of the <i>CACNA1A</i> gene (c.4055G&#x3e;A, p.R1352Q). The R1352Q <i>CACNA1A</i> variant shares the phenotype with other described <i>CACNA1A</i> mutations and highlights the interesting association of trauma as a precipitant for hemiplegic migraine. Subjects with early-onset sporadic hemiplegic migraine triggered by minor head injury or associated with seizures, ataxia or episodes of encephalopathy should be screened for mutations. These patients should also be advised to avoid activities that may result in head trauma, and anticonvulsants should be considered as prophylactic migraine therapy.

Fatal Cerebral oedema associated with hyponatraemia

1999 ◽  
Vol 16 (1) ◽  
pp. 1-2 ◽  
Author(s):  
John Rattenbury ◽  
S T Jones ◽  
S W Hancock
Keyword(s):  
Cerebral Oedema

Cerebral oedema in lambs associated with hypocuprosis, and its relationship to swayback

1966 ◽  
Vol 76 (3) ◽  
pp. 285-IN16 ◽  
Author(s):  
H.E. Roberts ◽  
B.M. Williams ◽  
A. Harvard
Keyword(s):  
Cerebral Oedema

Measurement of canine cerebral oedema using vector impedance methods

1991 ◽  
Vol 13 (4) ◽  
pp. 233-236 ◽  
Author(s):  
H.P. Kao ◽  
E. Shwedyk ◽  
E.R. Cardoso
Keyword(s):  
Cerebral Oedema

High altitude cerebral oedema

2016 ◽  
Vol 6 (3) ◽  
pp. 126-128 ◽  
Author(s):  
K.V.S. Hari Kumar ◽  
K.P. Shijith ◽  
Dalbara Singh
Keyword(s):  
High Altitude ◽  
Cerebral Oedema

Case report: Transient unilateral cerebral oedema in hemiplegic migraine: MR imaging and angiography

1996 ◽  
Vol 51 (1) ◽  
pp. 72-76 ◽  
Author(s):  
J.F.M. Meaney ◽  
C.E. Willaims ◽  
P.R.D. Humphrey
Keyword(s):  
Case Report ◽  
Mr Imaging ◽  
Cerebral Oedema ◽  
Hemiplegic Migraine

Cerebral Oedema

1992 ◽  
pp. 983-990
Author(s):  
J. D. Miller
Keyword(s):  
Cerebral Oedema

scholarly journals Paediatric bacterial meningitis in the USA: outcomes and healthcare resource utilization of nosocomial versus community-acquired infection

2020 ◽  
Author(s):  
Syed M. Adil ◽  
Sarah E. Hodges ◽  
Lefko T. Charalambous ◽  
Musa Kiyani ◽  
Beiyu Liu ◽  
...  
Keyword(s):  
Bacterial Meningitis ◽  
Hospital Mortality ◽  
Resource Utilization ◽  
Cerebral Oedema ◽  
Healthcare Resource ◽  
Healthcare Resource Utilization ◽  
Ventricular Catheter ◽  
Neurosurgical Procedures ◽  
The Usa ◽  
Multivariable Regression

Introduction. Paediatric bacterial meningitis remains a costly disease, both financially and clinically. Hypothesis/Gap Statement. Previous epidemiological and cost studies of bacterial meningitis (BM) have largely focused on adult populations or single pathogens. There have been few recent, large-scale studies of pediatric BM in the USA. Aim. We examined healthcare resource utilization (HCRU) and associated morbidity and mortality of community-acquired versus nosocomial bacterial infections in children across the USA. Methodology. The IBM MarketScan Research databases were used to identify patients <18 years old admitted to USA hospitals from 2008 to 2015 with a primary diagnosis of BM. Cases were categorized as either community-acquired or nosocomial. HCRU, post-diagnosis neurosurgical procedures, 30-day in-hospital mortality, and complications were compared between groups. Multivariable regression adjusted for sex, age and Gram staining was used to compare costs of nosocomial versus community-acquired infections over time. Results. We identified 1928 cases of paediatric BM without prior head trauma or neurological/systemic complications. Of these, 15.4 % were nosocomial and 84.6 % were community-acquired infections. After diagnostic lumbar puncture (37.1 %), the most common neurosurgical procedure was placement of ventricular catheter (12.6 %). The 30-day complication rates for nosocomial and community-acquired infections were 40.5 and 45.9 %, respectively. The most common complications were hydrocephalus (20.8 %), intracranial abscess (8.8 %) and cerebral oedema (8.1 %). The 30-day in-hospital mortality rates for nosocomial and community-acquired infections were 2.7 and 2.8 %, respectively. Median length of admission was 14.0 days (Q1: 7 days, Q3: 26 days). Median 90-day cost was $40 861 (Q1: $11 988, Q3: $114,499) for the nosocomial group and $56 569 (Q1: $26 127, Q3: $142 780) for the community-acquired group. In multivariable regression, the 90-day post-diagnosis total costs were comparable between groups (cost ratio: 0.89; 95 % CI: 0.70 to 1.13), but at 2 years post-diagnosis, the nosocomial group was associated with 137 % higher costs (CR: 2.37, 95 % CI: 1.51 to 3.70). Conclusion. In multivariable analysis, nosocomial infections were associated with significantly higher long-term costs up to 2 years post-infection. Hydrocephalus, intracranial epidural abscess and cerebral oedema were the most common complications, and lumbar punctures and ventricular catheter placement were the most common neurosurgical procedures. This study represents the first nation-wide, longitudinal comparison of the outcomes and considerable HCRU of nosocomial versus community-acquired paediatric BM, including characterization of complications and procedures contributing to the high costs of these infections.

scholarly journals Osmotic demyelination syndrome in a patient with Noonan syndrome and anterior hypopituitarism

2020 ◽  
Vol 2020 ◽  
Author(s):  
Tzy Harn Chua ◽  
Wann Jia Loh
Keyword(s):  
Noonan Syndrome ◽  
Cerebral Oedema ◽  
Early Recognition ◽  
Sodium Concentration ◽  
List Type ◽  
Rapid Rise ◽  
Osmotic Demyelination Syndrome ◽  
Severe Hyponatremia ◽  
Osmotic Demyelination ◽  
Learning Points

Summary Severe hyponatremia and osmotic demyelination syndrome (ODS) are opposite ends of a spectrum of emergency disorders related to sodium concentrations. Management of severe hyponatremia is challenging because of the difficulty in balancing the risk of overcorrection leading to ODS as well as under-correction causing cerebral oedema, particularly in a patient with chronic hypocortisolism and hypothyroidism. We report a case of a patient with Noonan syndrome and untreated anterior hypopituitarism who presented with symptomatic hyponatremia and developed transient ODS. Learning points: Patients with severe anterior hypopituitarism with severe hyponatremia are susceptible to the rapid rise of sodium level with a small amount of fluid and hydrocortisone. These patients with chronic anterior hypopituitarism are at high risk of developing ODS and therefore, care should be taken to avoid a rise of more than 4–6 mmol/L per day. Early recognition and rescue desmopressin and i.v. dextrose 5% fluids to reduce serum sodium concentration may be helpful in treating acute ODS.

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