Acute transplant rejection induced by blood transfusion reaction to the Kidd blood group system

Post-transfusion hemolytic complications (РНС) remain аn urgent рrоblem in medical practice despite the improvement of selecting methods of compatible blood transfusion for patients. The numbеr of РНС remains still high (1 in 6 000 - 29 000 transfusions). Aim: to analyze cases of РНС registered in health care facilities (HCF) in the Republic of Tajikistan. Method of investigation. Retrospective analysis of materials of national аnd regional committees оп investigation of РНС cases, histories fro hospital archives. During the period 1989-2014 in health facilities were registered 86 cases of РНС approximately 850 000 doses of red bооd cell transfusions containing blооd components, or 1 in 9418 doses of red blood cell-containing blood components. РНС reasons were: incompatibility of АВО blооd group system - 32 (37,3 %), antigen D of blооd group Rhesus factor system - 34 (39,53 %), according to minor blood group antigens of Rhesus factor and Kell blood group system (С, с, Е, е, К) - 16 (18,6 %). In 4 cases (4,6 %) the cases of РНС were hemolytic transfusions of erythrocyte-containing bags as а result of improper storage in domestic refrigeration without control of temperature storage. Causes of development 78 out of 86 РНС (90,69 %) were HCF doctors' mistakes, 8 (9,31 %) - mistakes of health personnel of health facilities departments of blood transfusion аnd regional blооd centers. Reducing the frequency of PHC is impossible without training physicians оn transfusion medicine, introduction of modern methods of phenotyping erythrocyte antigens of recipients and donors оn major transfusion significant blood group antigens the АВО system by direct and cross-over methods, Rhesus (С, с, Е, е), Kell (К) of patients requiring multiple transfusions, as well as to girls and women of childbearing age.

Download Full-text

The Duffy Blood Group System in Transfusion Reactions: A Review of the Literature and Report of Four Cases

Blood ◽

10.1182/blood.v15.1.186.186 ◽

1960 ◽

Vol 15 (1) ◽

pp. 186-191

Author(s):

ALLAN COMPTON ◽

JANE M. HABER

Keyword(s):

Blood Transfusion ◽

Incubation Period ◽

Blood Group ◽

Blood Group System ◽

Review Of The Literature ◽

Specific Identification ◽

Group System ◽

Duffy Blood Group ◽

Compatibility Test ◽

Transfusion Reactions

Abstract 1. The literature on the incidence and inheritance of the "Duffy" blood group factors and their significance in blood transfusion and erythroblastosis fetalis is briefly reviewed. 2. Four new cases in which anti-Fya was detected are reported. 3. The necessity for the use of the Coombs’ compatibility test with a potent Coombs’ serum to prevent reactions due to anti-Fya is re-emphasized. 4. The inadequacy of a 15 minute incubation period for the Coombs’ compatibility test in certain cases is noted. 5. The desirability of specific identification of an antibody detected in a patient’s serum prior to transfusion whenever possible is suggested.

Download Full-text

Rare blood donors with irregular antibodies

Medicinski pregled ◽

10.2298/mpns1308331k ◽

2013 ◽

Vol 66 (7-8) ◽

pp. 331-334

Author(s):

Mirjana Krga-Milanovic ◽

Nevenka Bujandric ◽

Natasa Milosavljevic-Knezevic

Keyword(s):

Blood Transfusion ◽

Red Blood Cells ◽

Blood Group ◽

Blood Donor ◽

Blood Cells ◽

High Frequency ◽

Blood Donors ◽

Blood Groups ◽

Blood Group System ◽

Group System

Introduction. Blood groups are inherited biological characteristics that do not change throughout life in healthy people. Blood groups represent antigens found on the surface of red blood cells. Kell blood group system consists of 31 antigens. Kell antigen (K) is present in 0.2% of the population (the rare blood group). Cellano antigen is present in more than 99% (the high-frequency antigen). These antigens have a distinct ability to cause an immune response in the people after blood transfusion or pregnancy who, otherwise, did not have them before. Case Report. This paper presents a blood donor with a rare blood group, who was found to have an irregular antibody against red blood cells by indirect antiglobulin test. Further testing determined the specificity of antibody to be anti-Cellano. The detected antibody was found in high titers (1024) with erythrocyte phenotype Kell-Cellano+. The blood donor was found to have a rare blood group KellKell. This donor was excluded from further blood donation. It is difficult to find compatible blood for a person who has developed an antibody to the high-frequency antigen. The donor?s family members were tested and Cellano antigen was detected in her husband and child. A potential blood donor was not found among the family members. There was only one blood donor in the Register of blood donors who was compatible in the ABO and Kell blood group system. Conclusion. For the successful management of blood transfusion it is necessary to establish a unified national register of donors of rare blood groups and cooperate with the International Blood Group Reference Laboratory in Bristol with the database that registers donors of rare blood groups from around the world.

Download Full-text