scholarly journals Low birth weight and nephron mass and their role in the progression of chronic kidney disease: a case report on identical twins with Alport disease

2011 ◽  
Vol 26 (12) ◽  
pp. 4136-4139 ◽  
Author(s):  
T. Rajan ◽  
S. J. Barbour ◽  
C. T. White ◽  
A. Levin
Keyword(s):  
Chronic Kidney Disease ◽  
Case Report ◽  
Birth Weight ◽  
Kidney Disease ◽  
Low Birth Weight ◽  
Identical Twins

scholarly journals Relationship between birth weight and chronic kidney disease: evidence from systematics review and two-sample Mendelian randomization analysis

2020 ◽  
Vol 29 (13) ◽  
pp. 2261-2274 ◽  
Author(s):  
Xinghao Yu ◽  
Zhongshang Yuan ◽  
Haojie Lu ◽  
Yixin Gao ◽  
Haimiao Chen ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Birth Weight ◽  
Kidney Disease ◽  
Low Birth Weight ◽  
Kidney Function ◽  
Large Scale ◽  
Mendelian Randomization ◽  
Negative Relationship ◽  
Sensitivity Analyses ◽  
Inverse Association

Abstract Observational studies showed an inverse association between birth weight and chronic kidney disease (CKD) in adulthood existed. However, whether such an association is causal remains fully elusive. Moreover, none of prior studies distinguished the direct fetal effect from the indirect maternal effect. Herein, we aimed to investigate the causal relationship between birth weight and CKD and to understand the relative fetal and maternal contributions. Meta-analysis (n = ~22 million) showed that low birth weight led to ~83% (95% confidence interval [CI] 37–146%) higher risk of CKD in late life. With summary statistics from large scale GWASs (n = ~300 000 for birth weight and ~481 000 for CKD), linkage disequilibrium score regression demonstrated birth weight had a negative maternal, but not fetal, genetic correlation with CKD and several other kidney-function related phenotypes. Furthermore, with multiple instruments of birth weight, Mendelian randomization showed there existed a negative fetal casual association (OR = 1.10, 95% CI 1.01–1.16) between birth weight and CKD; a negative but non-significant maternal casual association (OR = 1.09, 95% CI 0.98–1.21) was also identified. Those associations were robust against various sensitivity analyses. However, no maternal/fetal casual effects of birth weight were significant for other kidney-function related phenotypes. Overall, our study confirmed the inverse association between birth weight and CKD observed in prior studies, and further revealed the shared maternal genetic foundation between low birth weight and CKD, and the direct fetal and indirect maternal causal effects of birth weight may commonly drive this negative relationship.

scholarly journals SP279THE LINK BETWEEN LOW BIRTH WEIGHT AND CHRONIC KIDNEY DISEASE

2018 ◽  
Vol 33 (suppl_1) ◽  
pp. i437-i437
Author(s):  
Altynay Balmukhanova ◽  
Kairat Kabulbayev
Keyword(s):  
Chronic Kidney Disease ◽  
Birth Weight ◽  
Kidney Disease ◽  
Low Birth Weight

scholarly journals Perinatal factors contributing to chronic kidney disease in a cohort of Japanese children with very low birth weight

2020 ◽  
Author(s):  
Osamu Uemura ◽  
Kenji Ishikura ◽  
Tetsuji Kaneko ◽  
Daishi Hirano ◽  
Yuko Hamasaki ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Birth Weight ◽  
Kidney Disease ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Neonatal Period ◽  
Late Onset ◽  
Growth Restriction ◽  
Circulatory Collapse ◽  
Kidney Dysfunction

Abstract Background Developmental programming of chronic kidney disease (CKD) in young adults is linked to preterm birth and intrauterine growth restriction (IUGR). Which confers a higher risk of progression to chronic kidney damage in children with very low birth weight (VLBW; born weighing < 1500 g): prematurity or IUGR? Methods This is a national historical cohort study of children with VLBW cared for in perinatal medical centers in Japan. Predictive factors included three latent variables (prematurity, IUGR, stress during neonatal period) and eight observed variables (gestational age, birth weight Z-score, maternal age, duration of treatment with antibiotics and diuretics, maternal smoking, late-onset circulatory collapse, kidney dysfunction) during the perinatal period. The primary endpoint was estimated glomerular filtration rate (eGFR) at age ≥ 3 years. A structural equation model was used to examine the pathologic constitution. Results The 446 children with VLBW included 253 boys and 193 girls, of mean age 5.8 ± 2.6 years and mean eGFR 111.7 ml/min/1.73 m2 at last encounter. Pathway analyses showed intrauterine malnutrition (β = 0.85) contributed more to chronic kidney damage than stress during the neonatal period (β = − 0.19) and prematurity (β = 0.12), and kidney dysfunction and late-onset circulatory collapse were important observed variables in stress during the neonatal period. Conclusions IUGR was more harmful to future kidneys of VLBW neonates. Neonatal kidney dysfunction and late-onset circulatory collapse were important risk factors for subsequent CKD development. This emphasizes the need for obstetricians to monitor for fetal growth restriction and neonatologists to minimize neonatal stress to prevent CKD in later life.

New Insights into Acute-on-Chronic Kidney Disease in Nephrology Patients: The CKD-REIN Study

2021 ◽  
Author(s):  
Aghilès Hamroun ◽  
Luc Frimat ◽  
Maurice Laville ◽  
Marie Metzger ◽  
Christian Combe ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Birth Weight ◽  
Kidney Disease ◽  
Low Birth Weight ◽  
Hospital Discharge ◽  
Incidence Rates ◽  
High Rate ◽  
Cox Models ◽  
Ckd Stage

Abstract Background Acute-on-chronic kidney disease (ACKD) is poorly understood and often overlooked. We studied its incidence, circumstances, determinants, and outcomes in patients with CKD. Methods We used the Kidney Disease Improving Global Outcomes criteria to identify all-stage acute kidney injury (AKI) events in 3033 nephrology outpatients with CKD stage 3-5 participating in the CKD-REIN cohort study (2013-2020), and cause-specific Cox models to estimate hazard ratios (HR, 95% confidence intervals [CI]) of AKI-associated risk factors. Results At baseline, 22% of the patients (mean age 67 years, 65% men, mean eGFR 32 ml/min/1.73m2) had a history of AKI. Over a 3-year follow-up, 443 had at least one AKI event: 27% were stage 2 or 3, and 11% required dialysis; 74% involved hospitalization including 47% acquired as hospital inpatients; a third were not reported in hospital discharge reports. Incidence rates were 10.1 and 4.8 per 100 person-years in patients with and without an AKI history, respectively. In 2375 patients without this history, male sex, diabetes, cardiovascular disease, cirrhosis, several drugs, low eGFR, and serum albumin levels were significantly associated with a higher risk of AKI, as were low birth weight (&lt;2500 g) (adjusted HR, 1.98; 95%CI, 1.35 to 2.91) and hemoglobin level (HR 1.21; 1.12 to 1.32 per 1 g/dl decrease). Within one year, only 63% of the patients had recovered their previous kidney function, 13.7% had started kidney replacement therapy, and 12.7% had died. Conclusions The study highlights the high rate of hospital-acquired AKI events in patients with CKD, and their underreporting at hospital discharge. It also reveals low birth weight and anemia as possible new risk factors in CKD patients.

Prevalence of chronic kidney disease risk factors among low birth weight adolescents

2016 ◽  
Vol 31 (9) ◽  
pp. 1509-1516 ◽  
Author(s):  
Dev Darshan K. Khalsa ◽  
Hind A. Beydoun ◽  
J. Bryan Carmody
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Birth Weight ◽  
Kidney Disease ◽  
Low Birth Weight ◽  
Disease Risk ◽  
Chronic Kidney Disease Risk

scholarly journals Does indomethacin exposure increase risk for chronic kidney disease in very low birth weight infants?

2018 ◽  
Vol 1 (1) ◽  
Author(s):  
Amy C Blake ◽  
◽  
Katja M Gist ◽  
Claire Palmer ◽  
Danielle E Soranno ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Birth Weight ◽  
Kidney Disease ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Low Birth Weight Infants ◽  
Increase Risk

Low birth weight trends: possible impacts on the prevalences of hypertension and chronic kidney disease

2020 ◽  
Vol 43 (9) ◽  
pp. 859-868 ◽  
Author(s):  
Takeshi Kanda ◽  
Ayano Murai-Takeda ◽  
Hiroshi Kawabe ◽  
Hiroshi Itoh
Keyword(s):  
Chronic Kidney Disease ◽  
Birth Weight ◽  
Kidney Disease ◽  
Low Birth Weight

scholarly journals Familial contributions to the association between low birth weight and risk of chronic kidney disease in adult life

2021 ◽  
Author(s):  
Anna Gjerde ◽  
Rannveig Skrunes ◽  
Anna Varberg Reisæter ◽  
Hans-Peter Marti ◽  
Bjørn Egil Vikse
Keyword(s):  
Chronic Kidney Disease ◽  
Birth Weight ◽  
Kidney Disease ◽  
Low Birth Weight ◽  
Adult Life
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