scholarly journals FP570THE EFFECT OF HIV INFECTION ON SHORT TERM OUTCOMES AMONG PATIENTS UNDERGOING PERITONEAL DIALYSIS

2015 ◽  
Vol 30 (suppl_3) ◽  
pp. iii264-iii264
Author(s):  
Kwazi CZ Ndlovu ◽  
Alain Assounga
Keyword(s):  
Peritoneal Dialysis ◽  
Hiv Infection ◽  
Short Term

scholarly journals Bioimpedance Guided Fluid Management in Peritoneal Dialysis

2020 ◽  
Vol 15 (5) ◽  
pp. 685-694 ◽  
Author(s):  
Na Tian ◽  
Xiao Yang ◽  
Qunying Guo ◽  
Qian Zhou ◽  
Chunyan Yi ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Patient Survival ◽  
Fluid Management ◽  
Volume Overload ◽  
Short Term ◽  
Cardiovascular Disease Mortality ◽  
Technique Survival ◽  
Disease Mortality ◽  
Clinical Methods ◽  
And Control

Background and objectivesBioelectrical impedance analysis (BIA) devices can help assess volume overload in patients receiving maintenance peritoneal dialysis. However, the effects of BIA on the short-term hard end points of peritoneal dialysis lack consistency. This study aimed to test whether BIA-guided fluid management could improve short-term outcomes in patients on peritoneal dialysis.Design, setting, participants, & measurementsA single-center, open-labeled, randomized, controlled trial was conducted. Patients on prevalent peritoneal dialysis with volume overload were recruited from July 1, 2013 to March 30, 2014 and followed for 1 year in the initial protocol. All participants with volume overload were 1:1 randomized to the BIA-guided arm (BIA and traditional clinical methods) and control arm (only traditional clinical methods). The primary end point was all-cause mortality and secondary end points were cardiovascular disease mortality and technique survival.ResultsA total of 240 patients (mean age, 49 years; men, 51%; diabetic, 21%, 120 per group) were enrolled. After 1-year follow-up, 11(5%) patients died (three in BIA versus eight in control) and 21 patients were permanently transferred to hemodialysis (eight in BIA versus 13 in control). The rate of extracellular water/total body water decline in the BIA group was significantly higher than that in the control group. The 1-year patient survival rates were 96% and 92% in BIA and control groups, respectively. No significant statistical differences were found between patients randomized to the BIA-guided or control arm in terms of patient survival, cardiovascular disease mortality, and technique survival (P>0.05).ConclusionsAlthough BIA-guided fluid management improved the fluid overload status better than the traditional clinical method, no significant effect was found on 1-year patient survival and technique survival in patients on peritoneal dialysis.

Nierenersatzverfahren: Information, Aufklärung, Dokumentation

2018 ◽  
Vol 143 (12) ◽  
pp. 863-870
Author(s):  
Jan Galle ◽  
Jana Reitlinger
Keyword(s):  
Peritoneal Dialysis ◽  
Kidney Transplantation ◽  
Renal Replacement Therapy ◽  
Replacement Therapy ◽  
Kidney Donation ◽  
Living Donation ◽  
Short Term ◽  
Donor Kidney ◽  
Kidney Replacement Therapy ◽  
Caring Environment

AbstractIn renal replacement therapy, different methods are available: hemodialysis (HD), peritoneal dialysis (PD), and kidney transplantation (KTx). In addition, variants can be used: HD as a home HD or center HD, PD as a conventional PD or automated (cycler) PD, KTx as a potentially short-term predictable living donation or conventional donor kidney donation. The patient and his familiar or caring environment must be informed accordingly. This means first of all: information about which procedures of kidney replacement therapy are possible and can be offered. Then the specific risks associated with each procedure should be elucidated (e. g. HD and shunt bleeding, PD and peritonitis, KTx and infections/neoplasias). This necessarily includes a structured documentation of the educating center/doctor about the communicated information and decisions taken.

Clinical and Pharmacokinetic Evaluation of Long-Term Therapy With Didanosine in Children with HIV Infection

PEDIATRICS ◽  
1994 ◽  
Vol 94 (5) ◽  
pp. 724-731 ◽  
Author(s):  
Brigitta U. Mueller ◽  
Karina M. Butler ◽  
Vicki L. Stocker ◽  
Frank M. Balis ◽  
Philip A. Pizzo ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Area Under The Curve ◽  
Chronic Administration ◽  
Cd4 Count ◽  
Term Therapy ◽  
Short Term ◽  
Apparent Relationship ◽  
Term Administration ◽  
Long Term Therapy

Background. Didanosine has demonstrated promising antiviral activity and a tolerable toxicity profile in short term studies. We describe a cohort of HIV-infected children who were treated for a prolonged period of time with didanosine. Methods. Children (6 months to 18 years of age) with symptomatic HIV infection or an absolute CD4 count < 0.5 x 109 cells/L, received oral didanosine at doses between 20 mg/m2 to 180 mg/m2 every 8 hours. Clinical, immunological, and virological parameters were assessed at least every 2 months. The pharmacokinetics of didanosine were evaluated in 85 patients. Results. Previously untreated children (n = 51) and children who had received prior antiretroviral therapy (n = 52) were enrolled in the study (median time on study 22.6 months; range 2 to 48). The long-term administration of didanosine was well tolerated and no new toxicities were observed. The absolute CD4 count increased by ≥ .05 x 109 cells/L in 28 of 87 (32%) of patients after 6 months of therapy. Responses were also sustained in 41% of these children after 3 years of therapy. Children entering the study with a CD4 count >0.1 x 109 cells/L (n = 51) had a marked survival advantage (P = .00002) with an estimated survival probability after 3 years of 80% compared to 39% for children with lower CD4 counts. Although the area under the curve of didanosine increased proportionally with the dose, there was considerable interpatient variability at each dose level. There was no apparent relationship between surrogate markers of clinical outcome and plasma drug concentration. Conclusions. Didanosine was well tolerated with chronic administration, and toxicities were uncommon and usually reversible. In 41% of patients, the CD4 count increased and was maintained at the higher level even after years of treatment.

Short-term results of continuous venovenous haemodiafiltration versus peritoneal dialysis in 40 neonates with inborn errors of metabolism

2019 ◽  
Vol 178 (6) ◽  
pp. 829-836 ◽  
Author(s):  
Muhittin Celik ◽  
Osman Akdeniz ◽  
Nezir Ozgun ◽  
Mehmet Sah Ipek ◽  
Mehmet Nuri Ozbek
Keyword(s):  
Peritoneal Dialysis ◽  
Inborn Errors Of Metabolism ◽  
Short Term ◽  
Inborn Errors

A short term projection of HIV infection and AIDS cases in Cameroon

1992 ◽  
Vol 86 (4) ◽  
pp. 435-437 ◽  
Author(s):  
J.M. Garcia-Calleja ◽  
J.L. Mvondo ◽  
L. Zekeng ◽  
J.P. Louis ◽  
A. Trebucq ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Short Term

Effect of Short-Term Rosiglitazone Therapy in Peritoneal Dialysis Patients

2009 ◽  
Vol 29 (1) ◽  
pp. 108-111 ◽  
Author(s):  
Simon van Hooland ◽  
Olivier Boey ◽  
Patricia Van Der Niepen ◽  
Christiane Van Den Branden ◽  
Dierik Verbeelen
Keyword(s):  
Peritoneal Dialysis ◽  
Dialysis Patients ◽  
Short Term

scholarly journals Increased immunoglobulin G production by short term cultured duodenal biopsy samples from HIV infected patients

Gut ◽  
1998 ◽  
Vol 42 (3) ◽  
pp. 357-361 ◽  
Author(s):  
T Schneider ◽  
T Zippel ◽  
W Schmidt ◽  
G Pauli ◽  
U Wahnschaffe ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Immunoglobulin G ◽  
Duodenal Biopsy ◽  
Mucosal Inflammation ◽  
Short Term ◽  
Immunoglobulin Production ◽  
Secretory Immunity ◽  
Serum Iga ◽  
Intestinal Origin ◽  
Iga Production

Background—Secretory immunity is a major defence mechanism against infections at mucosal surfaces which are common in HIV infected patients.Aims—To analyse intestinal immunoglobulin production in HIV infection in comparison with that in saliva and serum.Patients and methods—Immunoglobulin G (IgG), A (IgA), and M (IgM) concentrations were determined in supernatants of short term cultured duodenal biopsy samples, serum, and saliva from HIV infected patients (n = 28) and controls (n = 14) by radial immunodiffusion.Results—IgG was increased in the supernatants of short term cultured biopsy samples and saliva from HIV infected patients compared with controls (p<0.01), but IgA and IgM levels were normal. In contrast, both IgG and IgA concentrations in serum were higher in HIV infected patients than in controls (p<0.002). No correlation was found between IgA produced by duodenal biopsy specimens and serum IgA.Conclusion—Abnormalities in mucosal immunoglobulin production in HIV infection were suprisingly small, indicating that specific secretory immunity rather than quantitative immunoglobulin production may be impaired. However, increased production of IgG could contribute to mucosal inflammation by complement activation. Our findings of normal mucosal IgA production and the lack of correlation between serum and mucosal IgA argues against an intestinal origin for the increased serum IgA levels in HIV infected patients.

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