scholarly journals MP698THE IMPACT OF HCV ON BONE DISEASE IN HEMODIALYSIS PATIENTS IMPACT OF HEPATITIS C VIRUS ON BONE DISEASE IN HEMODIALYSIS PATIENTS IMPACT OF HEPATITIS C VIRUS ON BONE DISEASE IN HEMODIALYSIS PATIENTS

2017 ◽  
Vol 32 (suppl_3) ◽  
pp. iii687-iii687
Author(s):  
Magdy ElSharkawy ◽  
Yasser Soliman ◽  
Howayda ElShennawy ◽  
Sahar Shawky ◽  
Mahmoud Montaser
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Bone Disease ◽  
Hemodialysis Patients

scholarly journals Effectiveness and safety of ombitasvir/paritaprevir/ritonavir in treatment of chronic hepatitis C Egyptian hemodialysis patients, case-control study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Nahla Mohamed Teama ◽  
Waleed Anwar Abdel-Mohsen ◽  
Ossama Ashraf Ahmed ◽  
Sarah Mohamed El Sayed ◽  
Ahmed Mohamed ElGhandour
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Case Control Study ◽  
Hemodialysis Patients ◽  
Hepatitis C Virus Infection ◽  
Chronic Hepatitis C Virus ◽  
Kidney Functions ◽  
Control Study

Abstract Background Prevalence of hepatitis C virus infection in patients with renal diseases is higher compared to the general population. FDA has approved ombitasvir/paritaprevir/ ritonavir for the treatment of patients with severe renal disease. This study aimed to evaluate the efficacy and safety of ombitasvir/paritaprevir/ritonavir with or without ribavirin in treatment of chronic hepatitis C Egyptian hemodialysis patients to compare it with the same treatment result in chronic hepatitis C Egyptian patients with normal renal functions. This case-control study was conducted on one hundred patients with confirmed diagnosis of HCV-positive infection at the Center of National Committee for Control of Viral Hepatitis [NCCVH] at Ain Shams University Hospital. Patients were divided into two groups: group I (control group) with 50 chronic hepatitis C virus patients with normal renal functions and group II (Case Group) with 50 chronic hepatitis C virus hemodialysis patients. Results 95.1% of prevalent hemodialysis patients achieved sustained virological response (SVR), while 100% of patients with normal kidney functions achieved sustained virological response. Most common side effects were hemoglobin drop, gastrointestinal disturbance, severe fatigue, and itching. Conclusion Ombitasvir, paritaprevir, and ritonavir are considered a safe and effective in treatment in HCV infection in patients on regular hemodialysis as in chronic hepatitis C virus infection patients with normal kidney functions.

Hepatitis C Virus-Related Acute and Chronic Hepatitis in Hemodialysis Patients

Nephron ◽  
1992 ◽  
Vol 61 (3) ◽  
pp. 322-323 ◽  
Author(s):  
M. Pluvio ◽  
A. Saggese ◽  
D. Cirillo ◽  
P. Castellino ◽  
R. Pempinello ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hemodialysis Patients ◽  
Acute And Chronic Hepatitis

New insights into hepatitis C virus infection of hemodialysis patients: the implications

1995 ◽  
Vol 25 (4) ◽  
pp. 572-578 ◽  
Author(s):  
K. Al Meshari ◽  
M. Al Ahdal ◽  
O. Alfurayh ◽  
A. Ali ◽  
E. De Vol ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Hemodialysis Patients ◽  
Hepatitis C Virus Infection

Prospective study of hepatitis C virus infection in hemodialysis patients by monthly analysis of HCV RNA and antibodies

2003 ◽  
Vol 49 (8) ◽  
pp. 503-507 ◽  
Author(s):  
Regina Moreira ◽  
João Renato Rebello Pinho ◽  
Jorge Fares ◽  
Isabel Takano Oba ◽  
Maria Regina Cardoso ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hemodialysis Patients ◽  
Hcv Infection ◽  
Hcv Rna ◽  
Hepatitis C Virus Infection ◽  
Serum Samples ◽  
Hcv Genotypes ◽  
High Prevalence ◽  
Time Required

The aims of this study were to (i) evaluate the prevalence and the incidence of hepatitis C virus (HCV) infection in hemodialysis patients in two different centers in São Paulo (Brazil), (ii) determine the time required to detect HCV infection among these patients by serology or PCR, (iii) establish the importance of alanine aminotransferase determination as a marker of HCV infection, and (iv) identify the HCV genotypes in this population. Serum samples were collected monthly for 1 year from 281 patients admitted to hospital for hemodialysis. Out of 281 patients, 41 patients (14.6%) were HCV positive; six patients seroconverted during this study (incidence = 3.1/1000 person-month). In 1.8% (5/281) of cases, RNA was detected before the appearance of antibodies (up to 5 months), and in 1.1% (3/281) of cases, RNA was the unique marker of HCV infection. The genotypes found were 1a, 1b, 3a, and 4a. The presence of genotype 4a is noteworthy, since it is a rare genotype in Brazil. These data pointed out the high prevalence and incidence of HCV infection at hemodialysis centers in Brazil and showed that routine PCR is fundamental for improving the detection of HCV carriers among patients undergoing hemodialysis.Key words: HCV genotypes, hemodialysis, hepatitis C, PCR, prevalence, incidence.

Hepatitis C virus genotypes in hemodialysis patients in Angola

2018 ◽  
Vol 91 (3) ◽  
pp. 518-521 ◽  
Author(s):  
Luis Filipe da Costa Marques Borges ◽  
Mariano Gustavo Zalis ◽  
Guilherme Santoro-Lopes ◽  
Rafael Brandão Varella
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hemodialysis Patients ◽  
Virus Genotypes ◽  
Hepatitis C Virus Genotypes

Antibodies against Hepatitis C Virus in Hemodialysis Patients in the Central Italian Region of Umbria: Evaluation of Some Risk Factors

Nephron ◽  
1992 ◽  
Vol 61 (3) ◽  
pp. 263-265 ◽  
Author(s):  
R. Brugnano ◽  
D. Francisci ◽  
G. Quintaliani ◽  
M. Gaburri ◽  
G. Nori ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hemodialysis Patients ◽  
Italian Region

scholarly journals Characterization of Occult Hepatitis C Virus (Hcv) Infection among Hemodialysis Patient

2017 ◽  
Vol 16 (1) ◽  
Author(s):  
Siti Nurul Fazlin Abdul Rahman ◽  
Hairul Aini binti Hamzah ◽  
Mohammed Imad Mustafa ◽  
Mohamed Hadzri Hasmoni
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hemodialysis Patients ◽  
Hcv Infection ◽  
Viral Rna ◽  
Cell Counting ◽  
Hcv Rna ◽  
Viral Rnas ◽  
Occult Hepatitis ◽  
Occult Hepatitis C

Introduction: The existence of new entity called occult hepatitis C virus (HCV) has become a raising and escalating concern among healthcare professionals worldwide. It is defined by the presence of viral RNA in liver and/or peripheral blood mononuclear cells (PBMCs) within non HCV-infected patients. Previous study had shown the occult HCV is infectious and capable of transmitting the virus to another host. Till today, HCV infection remains common among hemodialysis patients despite having the best preventive plans. Because of this, there is a significant concern about the source of viral transmission. The aim of the study was to identify and characterize occult HCV infection in PBMC sample of hemodialysis patients. This was an observational and cross sectional study. Materials and method: PBMCs were isolated from the whole blood using Ficoll-gradient centrifugation technique. The PBMCs were then subjected for cell counting and stored in -70O C until further used. HCV RNA were extracted from these cells and viral RNA were subjected for molecular assays, immune cells analysis and cells culture. Results: PBMCs were isolated from eleven (11) study patients and five (5) anti-HCV positive (control) patients. By using automated flow cytometry, PBMCs of each sample were counted and the average number of cells obtained range from 2x104 to 5x106 cells/ ml. Viral RNAs were extracted and quantitatively measured by using NanoDrop Spectrophotometers. The viral RNAs concentration obtained were between 24.7 and 258.9 ng/ml. The RNAs would be subjected for purification (ethanol precipitation) and further assays. Conclusion: The final findings might contribute to the clinical management of dialysis patients.

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