High-Fat, Low-Carbohydrate Diet and the Etiology of Non-Insulin-dependent Diabetes Mellitus: The San Luis Valley Diabetes Study

1991 ◽  
Vol 134 (6) ◽  
pp. 590-603 ◽  
Author(s):  
Julie A. Marshall ◽  
Richard F. Hamman ◽  
Judith Baxter
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Dependent Diabetes Mellitus ◽  
Dependent Diabetes Mellitus ◽  
High Fat ◽  
San Luis Valley ◽  
Carbohydrate Diet ◽  
Low Carbohydrate Diet ◽  
San Luis ◽  
Low Carbohydrate ◽  
Insulin Dependent

Hypertension in CB57BL/6J mouse model of non-insulin-dependent diabetes mellitus

1993 ◽  
Vol 264 (1) ◽  
pp. R73-R78 ◽  
Author(s):  
E. Mills ◽  
C. M. Kuhn ◽  
M. N. Feinglos ◽  
R. Surwit
Keyword(s):  
Diabetes Mellitus ◽  
Heart Rate Response ◽  
Control Diet ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
High Fat ◽  
Insulin Dependent ◽  
Hypotensive Response ◽  
Simple Carbohydrate

The C57BL/6J (BL/6) mouse develops non-insulin-dependent diabetes mellitus (NIDDM) when fed a high fat-high simple carbohydrate (HFHSC) diet, whereas A/J mice do not. The purpose of the study was to determine whether hypertension occurred with NIDDM and whether it was sustained by sympathetic nervous system (SNS) hyperactivity. After 3 mo on an HFHSC diet with a low Na content (0.06%), awake, tail-cuff systolic blood pressure (BP) increased 20% above the control diet in BL/6 (138 +/- 3 vs. 115 +/- 4) but not in A/J (115 +/- 6 vs. 113 +/- 2 mmHg) mice. On a normal Na (0.4%)-HFHSC diet, BL/6 mice had a higher BP than on 0.06% Na (149 +/- 3 at 3 mo, 162 +/- 6 at 4.5 mo). After 1 mo on the 0.06% Na-HFHSC diet, direct BP of anesthetized BL/6 mice was 18% higher than control. The hypotensive response to interruption of SNS activity by ganglionic blockade (chlorisondamine) increased in the BL/6 mice (50%), whereas the heart rate response increased in both strains (20-30%). Analysis of variance (ANOVA) on glucose detected significant effects of strain and diet and a strain x diet interaction (P = 0.0007). At 1 or 3 mo, HFHSC-fed BL/6 mice were hyperglycemic (> 11 mM) compared with diet or strain controls. The ANOVA on insulin detected strain and diet effects but not a strain x diet interaction (P = 0.3). HFHSC increased insulin above the control of 140-160 pM in A/J and BL/6 strain (20-70% at 1 mo, 400% at 3 mo).(ABSTRACT TRUNCATED AT 250 WORDS)

The Development of Diabetes Mellitus in Wistar Rats Kept on a High-Fat/Low-Carbohydrate Diet for Long Periods

Endocrine ◽  
2003 ◽  
Vol 22 (2) ◽  
pp. 85-92 ◽  
Author(s):  
Yuan Wang ◽  
Pei-Yu Wang ◽  
Li-Qiang Qin ◽  
Ganmaa Davaasambuu ◽  
Takashi Kaneko ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Wistar Rats ◽  
High Fat ◽  
Carbohydrate Diet ◽  
Low Carbohydrate Diet ◽  
Low Carbohydrate

scholarly journals OBESITY

2016 ◽  
Vol 23 (02) ◽  
pp. 198-203
Author(s):  
Muhammad Arif Ali ◽  
Faran Nasir
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Heart Diseases ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Fat Intake ◽  
High Fat ◽  
Insulin Dependent ◽  
Grade 3

Objectives: To find out the prevalence of risk factors of heart diseases in obesepatients. Study Design: Descriptive cross-sectional study. Setting: OPD of IndependentUniversity Hospital, Faisalabad. Period: One week duration extending from 4th to 10th May 2015.Patients and Methods: 90 Patients were selected by convenient sampling. A semi-structuredquestionnaire was used to collect the information from the sample. An informed consent wasalso obtained from the respondents under study and the secrecy of information was ensured.Results: Of the 90 patients under study, 33 (36.26%) were Grade 1 Obese, 51 (56.04%) wereGrade 2 Obese, and 7 (7.69%) were Grade 3 Obese. Among the patients 73.62% were nonsmokers,2.19% were former-smokers and 23.07% were smokers. Of the patients 15.38% werenon-diabetic, 12.08% had Insulin Dependent Diabetes Mellitus, 7.69% had Impaired GlucoseTolerance and 63.73% had Non-Insulin Dependent Diabetes Mellitus. Only 2 people of the91 who underwent the study were Alcoholics. Of them 1 had Grade 1 Obesity and the otherhad Grade 3 Obesity. 35.16% of the patients were non-hypertensive, 49.45% had Grade 1Hypertension, 5.49% had Grade 2 Hypertension and 5.49% had Grade 3 Hypertension. 26.37%patients had a sedentary life style while 53.84% had moderate and 18.68% had intense physicalactivity. 70.32% patients had a high fat intake while 28.57% had a low fat intake. Heart diseaseswere present in the fathers of 30.76% of patients, mothers of 13.18% patients and were presentin both father and mother of 7.69% patients. Conclusion: No significant trend in the increasein BMI and increased prevalence of cardiovascular risk factors was observed, however theincidence of some risk factors like diabetes and high fat intake was somehow in direct relationwith obesity.

Elevated Circulating P-Selectin in Insulin Dependent Diabetes Mellitus

1996 ◽  
Vol 76 (03) ◽  
pp. 328-332 ◽  
Author(s):  
Bernd Jilma ◽  
Peter Fasching ◽  
Christine Ruthner ◽  
Anna Rumplmayr ◽  
Sabine Ruzicka ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Plasma Levels ◽  
Plasma Concentrations ◽  
Insulin Dependent Diabetes Mellitus ◽  
Interquartile Range ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Intergroup Comparison ◽  
Median Plasma ◽  
Insulin Dependent

SummaryBased on findings that showed increased P-selectin expression on platelets and on choroidal microvessels of patients with insulin dependent diabetes mellitus (IDDM), we hypothesized that also plasma concentrations of circulating (c)P-selectin would be increased in these patients.The aim of this study was to compare the plasma levels of cP-selec-tin between non-smoking patients with IDDM, treated with an intensified insulin therapy, and healthy controls. The study design was prospective, cross-sectional and analyst-blinded. Subjects were matched individually for sex, age and body mass index. Plasma levels of cP-selectin and of von Willebrand antigen (vWF-Ag) were determined by enzyme linked immunoassays.Forty-two pairs were available for intergroup comparison. Median plasma concentrations of cP-selectin in patients with IDDM (285 ng/ml; interquartile range: 233-372) were on average 21% higher than those of controls (236 ng/ml; interquartile range: 175-296; p = 0.004). Also, median plasma levels of vWF-Ag were 10% higher in patients (96 U/dl; interquartile range: 82-127) than controls (87 U/dl; interquartile range: 70-104; p = 0.025). There was no correlation between plasma concentrations of cP-selectin and vWF-Ag levels in either group (p ώ0.05).In conclusion, our results of increased cP-selectin levels are in line with increased P-selectin expression on platelets and on choroidal microvessels found in patients with IDDM. In view of the currently developed small molecule inhibitors of cell adhesion molecules, these independent observations together may provide a sound rationale to select P-selectin as a target for treating or preventing IDDM-associated micro- or macrovascular complications.

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