Enhanced Ability of Heparin-Carrying Polystyrene (HCPS) to Bind to Heparin-Binding Growth Factors and to Inhibit Growth Factor-Induced Endothelial Cell Growth

2000 ◽  
Vol 127 (5) ◽  
pp. 797-803 ◽  
Author(s):  
M. Ishihara ◽  
K. Ono ◽  
K. Ishikawa ◽  
H. Hattori ◽  
Y. Saito ◽  
...  
Keyword(s):  
Growth Factors ◽  
Endothelial Cell ◽  
Growth Factor ◽  
Cell Growth ◽  
Heparin Binding ◽  
Heparin Binding Growth Factors ◽  
Endothelial Cell Growth

scholarly journals Purification and characterization of heparin-binding endothelial cell growth factors.

1986 ◽  
Vol 261 (4) ◽  
pp. 1924-1928
Author(s):  
R Lobb ◽  
J Sasse ◽  
R Sullivan ◽  
Y Shing ◽  
P D'Amore ◽  
...  
Keyword(s):  
Growth Factors ◽  
Endothelial Cell ◽  
Cell Growth ◽  
Heparin Binding ◽  
Purification And Characterization ◽  
Endothelial Cell Growth

scholarly journals Heparin-binding growth factor-I (endothelial cell growth factor) binds to endothelium in vivo

1988 ◽  
Vol 7 (2) ◽  
pp. 311-317 ◽  
Author(s):  
Todd K. Rosengart ◽  
John P. Kupferschmid ◽  
Victor J. Ferrans ◽  
Ward Casscells ◽  
Thomas Maciag ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Growth Factor ◽  
Cell Growth ◽  
Heparin Binding ◽  
Factor I ◽  
Endothelial Cell Growth Factor ◽  
Endothelial Cell Growth ◽  
Growth Factor I

scholarly journals Human endothelial cells are chemotactic to endothelial cell growth factor and heparin.

1985 ◽  
Vol 101 (6) ◽  
pp. 2330-2334 ◽  
Author(s):  
V P Terranova ◽  
R DiFlorio ◽  
R M Lyall ◽  
S Hic ◽  
R Friesel ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Cell Migration ◽  
Growth Factors ◽  
Endothelial Cell ◽  
Growth Factor ◽  
Cell Growth ◽  
Endothelial Cell Migration ◽  
Human Endothelial Cells ◽  
Endothelial Cell Growth Factor ◽  
Endothelial Cell Growth

The response of human endothelial cell migration to various extracellular matrix components and growth factors has been assessed. Human endothelial cells demonstrate increased chemotaxis and chemokinesis when placed in a modified Boyden chamber with endothelial cell growth factor (ECGF) used at a concentration of 10(-9) M. Anti-ECGF antibody inhibits the chemotactic response. Heparin (10(-8) to 10(-10) M) was also chemotactic and was shown to potentiate the chemotactic activity of ECGF. Although laminin, fibronectin, the polypeptide (epidermal, fibroblast, and nerve) growth factors, and collagen types I, II, III, IV, and V demonstrate a chemotactic response, these activities were one third to one half less than observed with ECGF. These data suggest that ECGF and heparin may play a significant role as response modifiers of human endothelial cell migration which may be relevant to tumor metastasis, wound healing, and atherogenesis.

Heparin-binding growth factor-I (endothelial cell growth factor) binds to endothelium in vivo

1988 ◽  
Vol 7 (2) ◽  
pp. 311-317 ◽  
Author(s):  
Todd K. Rosengart ◽  
John P. Kupferschmid ◽  
Victor J. Ferrans ◽  
Ward Casscells ◽  
Thomas Maciag ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Growth Factor ◽  
Cell Growth ◽  
Heparin Binding ◽  
Factor I ◽  
Endothelial Cell Growth Factor ◽  
Endothelial Cell Growth ◽  
Growth Factor I
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