Letter to the Editor Regarding a Recent Article: Meta-Analysis Comparing Celecoxib with Diclofenac Sodium in Patients with Knee Osteoarthritis

Pain Medicine ◽  
2021 ◽  
Author(s):  
Rajat N Moman ◽  
W Michael Hooten
Keyword(s):  
Knee Osteoarthritis ◽  
Recent Article ◽  
Meta Analysis ◽  
Diclofenac Sodium ◽  
Letter To The Editor

scholarly journals Meta-analysis Comparing Celecoxib with Diclofenac Sodium in Patients with Knee Osteoarthritis

Pain Medicine ◽  
2020 ◽  
Author(s):  
Hetao Huang ◽  
Minghui Luo ◽  
Haodong Liang ◽  
Jianke Pan ◽  
Weiyi Yang ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Complication Rate ◽  
Meta Analysis ◽  
Diclofenac Sodium ◽  
Controlled Trials ◽  
Reactive Protein ◽  
Randomized Controlled ◽  
Vas Score ◽  
Online Databases ◽  
Review Manager

Abstract Objective To compare the efficacy and safety of celecoxib and diclofenac sodium in patients with knee osteoarthritis (KOA). Methods Clinical controlled trials (CCTs) and randomized controlled trials (RCTs) from online databases comparing the efficacy of celecoxib and diclofenac sodium in the treatment of KOA were retrieved. The main outcomes included the treatment effect, C-reactive protein (CRP) level, erythrocyte sedimentation rate (ESR), visual analog scale (VAS) score, and complication rate. The Cochrane risk of bias (ROB) tool in Review Manager 5.3.5 was used to assess methodological quality. Results Twelve studies (N = 2,350) were included in this meta-analysis. The meta-analysis indicated that celecoxib reduced pain more effectively than diclofenac sodium in patients with KOA, as evaluated by the VAS score. In addition, celecoxib has certain advantages in terms of better treatment effects and greater reductions in the ESR, CRP level, and complication rate. Conclusions Celecoxib is superior to diclofenac sodium in the treatment of KOA. However, well-designed and high-quality RCTs are still needed.

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