Comparison of conservation within and between the Ser/Thr and Tyr protein kinase family: proposed model for the catalytic domain of the epidermal growth factor receptor

1994 ◽  
Vol 7 (7) ◽  
pp. 849-858 ◽  
Author(s):  
Juswinder Singh
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Protein Kinase ◽  
Epidermal Growth Factor ◽  
Catalytic Domain ◽  
Growth Factor Receptor ◽  
Protein Kinase Family ◽  
Kinase Family ◽  
Proposed Model ◽  
Epidermal Growth

scholarly journals Multiple mechanisms collectively regulate clathrin-mediated endocytosis of the epidermal growth factor receptor

2010 ◽  
Vol 189 (5) ◽  
pp. 871-883 ◽  
Author(s):  
Lai Kuan Goh ◽  
Fangtian Huang ◽  
Woong Kim ◽  
Steven Gygi ◽  
Alexander Sorkin
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Protein Kinase ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Adaptor Protein ◽  
Kinase Domain ◽  
Mitogen Activated Protein Kinase ◽  
Epidermal Growth ◽  
Egfr Mutant

Endocytosis of the epidermal growth factor receptor (EGFR) is important for the regulation of EGFR signaling. However, EGFR endocytosis mechanisms are poorly understood, which precludes development of approaches to specifically inhibit EGFR endocytosis and analyze its impact on signaling. Using a combination of receptor mutagenesis and RNA interference, we demonstrate that clathrin-dependent internalization of activated EGFR is regulated by four mechanisms, which function in a redundant and cooperative fashion. These mechanisms involve ubiquitination of the receptor kinase domain, the clathrin adaptor complex AP-2, the Grb2 adaptor protein, and three C-terminal lysine residues (K1155, K1158, and K1164), which are acetylated, a novel posttranslational modification for the EGFR. Based on these findings, the first internalization-defective EGFR mutant with functional kinase and normal tyrosine phosphorylation was generated. Analysis of the signaling kinetics of this mutant revealed that EGFR internalization is required for the sustained activation of protein kinase B/AKT but not for the activation of mitogen-activated protein kinase.

scholarly journals Epidermal Growth Factor Receptor and Protein Kinase C Signaling to ERK2

2008 ◽  
Vol 283 (10) ◽  
pp. 6241-6252 ◽  
Author(s):  
Christopher J. Caunt ◽  
Caroline A. Rivers ◽  
Becky L. Conway-Campbell ◽  
Michael R. Norman ◽  
Craig A. McArdle
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Protein Kinase C ◽  
Growth Factor ◽  
Protein Kinase ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Kinase C ◽  
Epidermal Growth
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