Comparison between the Efficacy of Intense Pulsed Light (IPL) versus Photodynamic Therapy with Methylene Blue in the Treatment of Nail Psoriasis

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Maha Adel Shaheen ◽  
Samah Ibrahim Hassen ◽  
Azzahra Omar Dakhli
Keyword(s):  
Methylene Blue ◽  
Photodynamic Therapy ◽  
Therapeutic Option ◽  
Group Versus ◽  
Treatment Session ◽  
Intense Pulsed Light ◽  
Pulsed Light ◽  
Nail Psoriasis ◽  
Significant Difference

Abstract Background Nail psoriasis is often refractory to traditional treatments, and patients with nail psoriasis usually demand a therapeutic option. Both photodynamic therapy (PDT) and intense pulsed light have been evaluated in nail psoriasis. Objective The objective of this study was to evaluate and compare the efficacy of IPL and methylene blue assisted photodynamic therapy in the treatment of nail psoriasis. Patients and Methods Twenty patients (15 males and 5 females) with mild to moderate psoriasis with nail affection were included in this study. Their age ranged from 24 to 71 years. The PDT used IPL as the light source and methylene blue as photosensitizer. Sessions were applied every 2 weeks for a maximum of 3 months, treating one hand with IPL and the other with PDT. The nails treated were evaluated at baseline, after 2 sessions, after 6 sessions and 3 months after the last treatment session according to the Nail Psoriasis Severity Index (NAPSI) score. Follow-up was performed after 2 sessions, after 6 sessions, and 3 months after the last treatment session. Results A decrease in NAPSI score was observed with both treatments and in both nail bed and nail matrix involvement. No statistically significant difference was found between PDT and IPL as regarding total NPASI score. However, total NAPSI score improved by 61% in MB-PDT group versus 47% in IPL group. Patient follow-up revealed the appearance of new lesions in 3 patients in the group of IPL, and in 1 patient in the MB-PDT after 6 months. Conclusion Intense pulsed light and methylene blue assisted PDT are a promising effective modalities of treatment of nail psoriasis, which are easy to use, safe, and nearly pain-free. This was confirmed by the improvement NAPSI score.

scholarly journals Evaluation of Topical Photo-Enhancer Assisted Intense Pulsed Light versus Methylene Blue Assisted Intense Pulsed Light for Treatment of Seborrheic Keratosis

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
G F Mohammed ◽  
K M A Alzawahry ◽  
M M Atef ◽  
I M Salahuldin
Keyword(s):  
Methylene Blue ◽  
Photodynamic Therapy ◽  
Intense Pulsed Light ◽  
Pulsed Light ◽  
University Hospitals ◽  
Seborrheic Keratosis ◽  
Clinical Variants ◽  
Carbon Gel ◽  
Intense Light ◽  
Comparative Prospective Study

Abstract Background seborrheic keratosis is one of the most common benign epidermal tumors that affects both sexes equally, and usually arises in individuals older than 50 years. It presents as sharply demarcated, slightly raised brownish patches or plaques, usually on sun-exposed surfaces of the skin. The clinical presentation can be quite variable and includes clinical variants, such as stucco keratosis and dermatosis papulosa nigra. Aim of the Work to evaluate the efficacy and safety of topical carbon gel photo-enhancer assisted intense pulsed light versus methylene blue assisted intense pulsed light photodynamic therapy for treatment of Seborrheic Keratosis. Patients and Methods this is a comparative prospective study that included thirty patients of skin types III to V Fitzpatrick class having multiple Seborrheic Keratosis lesions with no sex or age predilection. They were randomly recruited from Dermatology out-patient clinic of Ain –Shams University Hospitals, during period from June 2017 till March 2018. The study was approved by Research Ethical Committee of Ain Shams University and fulfilled all the ethical aspects required for human research. Results this denoted that the methylene blue-mediated photodynamic therapy (MB-PDT) (liposomal-loaded methylene blue gel 10%).and topical carbon gel photo-enhancer assisted intense pulsed light). could be effective in treating patients with Sks. Our findings denote the efficacy of them in curing multiple Sk lesions. The efficacy of methylene blue-mediated photodynamic therapy (MB-PDT) (liposomal-loaded methylene blue gel 10%). Conclusion that Intense Light Pulse using liposomal-loaded MB and Topical carbon suspension-assisted IPL treatment could be a good option for patients with indistinct pigmented or thick melanogenesic lesions. Adverse reactions to this treatment were minimal and the results acceptable, though appropriate lesions need to be chosen care- fully.

scholarly journals Comparative Study of Efficacy of Glycolic Acid Peel and Intense Pulsed Light in the Treatment of Melasma

2015 ◽  
Vol 2 (1) ◽  
pp. 39
Author(s):  
Snehal P. Desale ◽  
Anil S. Gugle ◽  
Rahul Kote ◽  
Vikrant M. Jadhav
Keyword(s):  
Glycolic Acid ◽  
Difficult Problem ◽  
Intense Pulsed Light ◽  
Pulsed Light ◽  
Health Care Centre ◽  
Medical College ◽  
Group 4 ◽  
Significant Difference ◽  
Chemical Peeling

<strong>Background:</strong> Melasma, one of the common aesthetically displeasing entities, continues to be a difficult problem to treat. Chemical peeling is one new weapon in the therapeutic armamentarium of melasma. Intense Pulsed Light (IPL) is a noncoherent, broad-spectrum light, ranging from 500 to 1200 nm. Intense Pulsed Light (IPL) treatment is a good option for patients with melasma. <strong>Aims and Objective:</strong> To compare the efficacy of glycolic acid peel and intense pulsed light in the treatment of melasma. <strong>Setting:</strong> Outpatient department of Dermatology, Venerology Leprology of a tertiary health care centre with an attached medical college. <strong>Material and Methods:</strong> 60 patients of melasma were recruited in the study. Patients were randomly allocated into two groups: one group (glycolic acid 50%) and another group (IPL) with 30 patients in each group. All the participants were subjected to undergo pre-peel programme of daily application of sunscreens (day time) and 0.025% retinoic acid at bed time for two weeks in GA peel group. 4 peels were carried out at 2 weekly intervals. Four sessions of IPL were done at 3 weeks interval. MASI scoring and coloured photographs (without reavealing identity) of each patient were taken before each peel and at the end of the follow-up period i.e. 2 weeks after 4<sup>th</sup> sitting in GA peel group and 3 weeks after 4<sup>th</sup> sitting in IPL group. Side effects, if any, were also recorded. <strong>Statistical Analysis Used:</strong> SYSTAT version-12. <strong>Results:</strong> In both the groups there was constant decrease in MASI scores after each sitting as compared to pre-peel scores. However, the comparison of mean MASI scores i.e. both pre-peel and after each peel, between the two groups showed statistically significant difference (<em>p&lt;0.05</em>). Local reactions, such as burning sensation and erythema during the peel were not significant with both the groups. <strong>Conclusions:</strong> Glycolic Acid (GA) peel (50%) is more efficacious&amp;safe treatment modality in melasma compared to IPL.

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