Long-Term Murine Hemopoietic Cultures as Model Systems for Analysis of B Lymphocyte Differentiation

Author(s):  
K. Dorshkind ◽  
O. N. Witte
1977 ◽  
Vol 31 (2) ◽  
pp. 340-348 ◽  
Author(s):  
J. Rozing ◽  
N.H.C. Brons ◽  
R. Benner

1979 ◽  
Vol 27 (5) ◽  
pp. 315-318 ◽  
Author(s):  
Robert B. Ettenger ◽  
Christel H. Uittenbogaart ◽  
Alfred J. Pennisi ◽  
Mohammad H. Malekzadeh ◽  
Richard N. Fine

2021 ◽  
Author(s):  
Oliver Krueger ◽  
Frauke Feser ◽  
Christopher Kadow ◽  
Ralf Weisse

<p>Global atmospheric reanalyses are commonly applied for the validation of climate models, diagnostic studies, and driving higher resolution numerical models with the emphasis on assessing climate variability and long-term trends. Over recent years, longer reanalyses spanning a period of more than hundred years have become available. In this study, the variability and long-term trends of storm activity is assessed over the northeast Atlantic in modern centennial reanalysis datasets, namely ERA-20cm, ERA-20c, CERA-20c, and the 20CR-reanalysis suite with 20CRv3 being the most recent one. All reanalyses, except from ERA-20cm, assimilate surface pressure observations, whereby ERA-20C and CERA-20c additionally assimilate surface winds. For the assessment, the well-established storm index of higher annual percentiles of geostrophic wind speeds derived from pressure observations at sea level over a relatively densely monitored marine area is used.</p><p>The results indicate that the examined centennial reanalyses are not able to represent long-term trends of storm activity over the northeast Atlantic, particularly in the earlier years of the period examined when compared with the geostrophic wind index based on pressure observations. Moreover, the reanalyses show inconsistent long-term behaviour when compared with each other. Only in the latter half of the 20th century, the variability of reanalysed and observed storminess time series starts to agree with each other. Additionally, 20CRv3, the most recent centennial reanalysis examined, shows markedly improved results with increased uncertainty, albeit multidecadal storminess variability does not match observed values in earlier times before about 1920.</p><p>The behaviour shown by the centennial reanalyses are likely caused by the increasing number of assimilated observations, changes in the observational databases used, and the different underlying numerical model systems. Furthermore, the results derived from the ERA-20cm reanalysis that does not assimilate any pressure or wind observations suggests that the variability and uncertainty of storminess over the northeast Atlantic is high making it difficult to determine storm activity when numerical models are not bound by observations. The results of this study imply and reconfirm previous findings that the assessment of long-term storminess trends and variability in centennial reanalyses remains a rather delicate matter, at least for the northeast Atlantic region.</p>


2021 ◽  
Vol 8 ◽  
Author(s):  
Mingming Liu ◽  
Boyu Yuan ◽  
Xinxin Jin ◽  
Mingqiang Zhu ◽  
Haidong Xu ◽  
...  

Newborn piglets are prone to diarrhea after weaning as a result of changes in their environment and feed. Enterotoxigenic Escherichia coli (ETEC) K88 strain is a typical pathogen that causes diarrhea in such stage of piglets. Hermetia illucens larvae are widely used in livestock and poultry production because of their high nutritional value and immunoregulatory effects. This study aimed to evaluate the protective effects of H. illucens feed in protecting against ETEC induced diarrhea in piglets and to unravel the mechanisms of immune modulation and intestinal barrier maintenance. The results showed that after ETEC infection, citric acid in the serum of the groups fed on H. illucens larvae increased significantly, which stimulated macrophages to secrete cytokines that promote B lymphocyte differentiation, ultimately increasing the production of IgA and IgG in serum. Concomitantly, citric acid also had a positive effect on the intestinal barrier damaged due to ETEC infection by inhibiting the production of inflammatory cytokines, reducing the Bcl-2/Bax ratio, and promoting the expression of tight junction proteins. Correlation analysis showed that the increase of citric acid levels might be related to Massilia. Thus, citric acid derived from H. illucens larvae can improve the immune performance of weaned piglets and reduce ETEC-induced damage to the intestinal barrier in weaned piglets.


Cell ◽  
2004 ◽  
Vol 119 (1) ◽  
pp. 75-86 ◽  
Author(s):  
Naoyuki Fujita ◽  
David L. Jaye ◽  
Cissy Geigerman ◽  
Adil Akyildiz ◽  
Myesha R. Mooney ◽  
...  

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