Clinical analysis of anti-NR2 glutamate receptor antibodies and interleukin-6 with neuropsychiatric systemic lupus erythematosus

Rheumatology ◽

10.1093/rheumatology/ker272 ◽

2011 ◽

Vol 50 (11) ◽

pp. 2142-2144 ◽

Author(s):

S. Sato ◽

H. Kawashima ◽

A. Hoshika ◽

T. Yoshio

Keyword(s):

Systemic Lupus Erythematosus ◽

Glutamate Receptor ◽

Lupus Erythematosus ◽

Interleukin 6 ◽

Clinical Analysis ◽

Systemic Lupus ◽

Neuropsychiatric Systemic Lupus Erythematosus ◽

Receptor Antibodies

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Association of cerebrospinal fluid anti-NR2 glutamate receptor antibodies with diffuse neuropsychiatric systemic lupus erythematosus

Arthritis & Rheumatism ◽

10.1002/art.23399 ◽

2008 ◽

Vol 58 (4) ◽

pp. 1130-1135 ◽

Author(s):

Yoshiyuki Arinuma ◽

Tamiko Yanagida ◽

Shunsei Hirohata

Keyword(s):

Systemic Lupus Erythematosus ◽

Cerebrospinal Fluid ◽

Glutamate Receptor ◽

Lupus Erythematosus ◽

Systemic Lupus ◽

Neuropsychiatric Systemic Lupus Erythematosus ◽

Receptor Antibodies

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Association of IgG anti-NR2 glutamate receptor antibodies in cerebrospinal fluid with neuropsychiatric systemic lupus erythematosus

Arthritis & Rheumatism ◽

10.1002/art.21547 ◽

2006 ◽

Vol 54 (2) ◽

pp. 675-678 ◽

Author(s):

Taku Yoshio ◽

Koichi Onda ◽

Hiroyuki Nara ◽

Seiji Minota

Keyword(s):

Systemic Lupus Erythematosus ◽

Cerebrospinal Fluid ◽

Glutamate Receptor ◽

Lupus Erythematosus ◽

Systemic Lupus ◽

Neuropsychiatric Systemic Lupus Erythematosus ◽

Receptor Antibodies

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Limbic encephalitis in a patient with systemic lupus erythematosus successfully treated with high-dose glucocorticoids and intravenous cyclophosphamide therapy: the potential pathogenicity of anti-glutamate receptor antibodies

Modern Rheumatology Case Reports ◽

10.1080/24725625.2021.1876340 ◽

2021 ◽

pp. 1-6

Author(s):

Haruka Tsuchiya ◽

Yukiko Iwasaki ◽

Hirofumi Shoda ◽

Yukitoshi Takahashi ◽

Keishi Fujio

Keyword(s):

Systemic Lupus Erythematosus ◽

Glutamate Receptor ◽

Lupus Erythematosus ◽

Limbic Encephalitis ◽

High Dose ◽

Systemic Lupus ◽

Intravenous Cyclophosphamide ◽

Cyclophosphamide Therapy ◽

Potential Pathogenicity ◽

Receptor Antibodies

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FRI0297 Role of serum interleukin-6 in blood brain barrier damages in neuropsychiatric systemic lupus erythematosus

10.1136/annrheumdis-2017-eular.2806 ◽

2017 ◽

Author(s):

S Hirohata ◽

Y Matsueda ◽

T Yanagida ◽

T Yoshio

Keyword(s):

Systemic Lupus Erythematosus ◽

Blood Brain Barrier ◽

Lupus Erythematosus ◽

Interleukin 6 ◽

Brain Barrier ◽

Systemic Lupus ◽

Neuropsychiatric Systemic Lupus Erythematosus ◽

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Glutamate Receptor Biology and its Clinical Significance in Neuropsychiatric Systemic Lupus Erythematosus

Rheumatic Disease Clinics of North America ◽

10.1016/j.rdc.2009.12.007 ◽

2010 ◽

Vol 36 (1) ◽

pp. 187-201 ◽

Author(s):

Cynthia Aranow ◽

Betty Diamond ◽

Meggan Mackay

Keyword(s):

Systemic Lupus Erythematosus ◽

Clinical Significance ◽

Glutamate Receptor ◽

Lupus Erythematosus ◽

Systemic Lupus ◽

Neuropsychiatric Systemic Lupus Erythematosus ◽

Receptor Biology

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Evaluation of blood-brain barrier function by quotient alpha2 macroglobulin and its relationship with interleukin-6 and complement component 3 levels in neuropsychiatric systemic lupus erythematosus

PLoS ONE ◽

10.1371/journal.pone.0186414 ◽

2017 ◽

Vol 12 (10) ◽

pp. e0186414 ◽

Author(s):

Tomoyuki Asano ◽

Hiromi Ito ◽

Yoshinobu Kariya ◽

Kyoka Hoshi ◽

Akioh Yoshihara ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Blood Brain Barrier ◽

Lupus Erythematosus ◽

Interleukin 6 ◽

Barrier Function ◽

Complement Component ◽

Brain Barrier ◽

Systemic Lupus ◽

Neuropsychiatric Systemic Lupus Erythematosus ◽

Complement Component 3

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GLUTAMATE RECEPTOR ANTIBODIES IN NEUROLOGICAL DISEASES: Anti-AMPA-GluR3 antibodies, Anti-NMDA-NR1 antibodies, Anti-NMDA-NR2A/B antibodies, Anti-mGluR1 antibodies or Anti-mGluR5 antibodies are present in subpopulations of patients with either: Epilepsy, Encephalitis, Cerebellar Ataxia, Systemic Lupus Erythematosus (SLE) and Neuropsychiatric SLE, Sjogren’s syndrome, Schizophrenia, Mania or Stroke. These autoimmune anti-glutamate receptor antibodies can bind neurons in few brain regions, activate glutamate receptors, decrease glutamate receptor’s expression, impair glutamate-induced signaling and function, activate Blood Brain Barrier endothelial cells, kill neurons, damage the brain, induce behavioral/psychiatric/cognitive abnormalities and Ataxia in animal models, and can be removed or silenced in some patients by immunotherapy

Journal of Neural Transmission ◽

10.1007/s00702-014-1193-3 ◽

2014 ◽

Vol 121 (8) ◽

pp. 1029-1075 ◽

Author(s):

Mia Levite

Keyword(s):

Systemic Lupus Erythematosus ◽

Glutamate Receptor ◽

Lupus Erythematosus ◽

Neurological Diseases ◽

Brain Regions ◽

Systemic Lupus ◽

Neuropsychiatric Sle ◽

And Function ◽

Receptor Antibodies ◽

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Enhanced interleukin-6 messenger RNA expression by neuronal cells in a patient with neuropsychiatric systemic lupus erythematosus

Arthritis & Rheumatism ◽

10.1002/1529-0131(199912)42:12<2729::aid-anr35>3.0.co;2-i ◽

1999 ◽

Vol 42 (12) ◽

pp. 2729-2730 ◽

Author(s):

Shunsei Hirohata ◽

Kinya Hayakawa

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Interleukin 6 ◽

Messenger Rna ◽

Neuronal Cells ◽

Rna Expression ◽

Systemic Lupus ◽

Neuropsychiatric Systemic Lupus Erythematosus

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FRI0397 Relationship between Igg Anti-Nr2 Glutamate Receptor Antibodies and Depressive/Anxiety Symptoms in Patients with Systemic Lupus Erythematosus

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2014-eular.2633 ◽

2014 ◽

Vol 73 (Suppl 2) ◽

pp. 531.1-531

Author(s):

C.C. Mok ◽

K.L. Chan ◽

B. Diamond

Keyword(s):

Systemic Lupus Erythematosus ◽

Glutamate Receptor ◽

Lupus Erythematosus ◽

Anxiety Symptoms ◽

Systemic Lupus ◽

Receptor Antibodies

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MR Manifestations of the Brain in Neuropsychiatric Systemic Lupus Erythematosus Patients

Journal of the Korean Radiological Society ◽

10.3348/jkrs.2008.58.1.1 ◽

2008 ◽

Vol 58 (1) ◽

pp. 1 ◽

Author(s):

Kyu Chan Oh ◽

Woo Mok Byun ◽

Han Won Jang ◽

Kum Rae Kim

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Systemic Lupus ◽

Neuropsychiatric Systemic Lupus Erythematosus ◽

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