scholarly journals 4.2 Striatal Glutamate as Biomarker of Clinical Response to First-Line Treatment in Antipsychotic-naïve, First-Episode Psychosis Patients

2017 ◽  
Vol 43 (suppl_1) ◽  
pp. S5-S5
Author(s):  
Camilo de la Fuente-Sandoval ◽  
Francisco Reyes-Madrigal ◽  
Pablo León-Ortiz ◽  
Ariel Graff-Guerrero
Keyword(s):  
Clinical Response ◽  
First Episode Psychosis ◽  
First Episode ◽  
Line Treatment ◽  
First Line ◽  
Episode Psychosis ◽  
First Line Treatment

Long‐acting antipsychotic medication as first‐line treatment of first‐episode psychosis with comorbid substance use disorder

2019 ◽  
Vol 14 (1) ◽  
pp. 69-79 ◽  
Author(s):  
Amal Abdel‐Baki ◽  
Dominic Thibault ◽  
Sofia Medrano ◽  
Emmanuel Stip ◽  
Martin Ladouceur ◽  
...  
Keyword(s):  
Substance Use ◽  
Substance Use Disorder ◽  
Antipsychotic Medication ◽  
First Episode Psychosis ◽  
First Episode ◽  
Line Treatment ◽  
First Line ◽  
Episode Psychosis ◽  
Long Acting ◽  
First Line Treatment

scholarly journals Augmentative Asenapine in a Recurrent Manic Catatonic Patient with Partial Response to Clozapine

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Massimiliano Buoli ◽  
Cristina Dobrea ◽  
Alice Caldiroli ◽  
Laura Cremaschi ◽  
A. Carlo Altamura
Keyword(s):  
Partial Response ◽  
Clinical Response ◽  
Electroconvulsive Therapy ◽  
Atypical Antipsychotics ◽  
Line Treatment ◽  
First Line ◽  
Long Time ◽  
Bipolar Patients ◽  
Positive Results ◽  
First Line Treatment

Catatonia is a severe but treatable neuropsychiatric syndrome known since the middle of the nineteenth century. It has been considered for a long time as a subtype of schizophrenia, even though this association occurs only in 10% of cases. In contrast, it is frequently observed in bipolar patients. First-line treatment consists of benzodiazepines, while in case of resistance electroconvulsive therapy (ECT) and clozapine have shown positive results. In addition, recent studies reported the efficacy of some atypical antipsychotics. The present case shows the clinical response to augmentative asenapine in a catatonic manic patient with a partial response to clozapine.

scholarly journals A cross-sectional mixed methods protocol to describe correlates and explanations for a long duration of untreated psychosis among patients with first episode psychosis in Uganda

BMJ Open ◽  
2019 ◽  
Vol 9 (7) ◽  
pp. e028029 ◽  
Author(s):  
Emmanuel Kiiza Mwesiga ◽  
Noeline Nakasujja ◽  
Linnet Ongeri ◽  
Aggrey Semeere ◽  
Rachel Loewy ◽  
...  
Keyword(s):  
Mixed Methods ◽  
Psychotic Disorders ◽  
Sub Saharan Africa ◽  
Qualitative Assessment ◽  
First Episode ◽  
Line Treatment ◽  
Duration Of Untreated Psychosis ◽  
First Line ◽  
Medicine Research ◽  
First Line Treatment

IntroductionAmong patients with psychotic disorders, the ‘duration of untreated psychosis’ (DUP) is a predictor of key outcomes such as symptom remission and quality of life. In sub-Saharan Africa, DUP is up to five times longer than in high-income countries, with many patients going without antipsychotic medication for 5 years or longer. One contributor to this high DUP may relate to cultural norms that drive use of alternative and complementary therapies (ACTs) as first-line treatment strategies, rather than biomedical care with antipsychotic medicine. We aim to1determine the prevalence and factors associated with DUP and ACT use in Uganda, and2Identify factors that drive patient and family choices to use ACT as a first-line treatment strategy.Methods and analysisWe will leverage on an ongoing cohort study at the national psychiatric and teaching hospital in Uganda. The parent study is an observational cohort design following antipsychotic naïve adults with a first episode of psychosis without substance use, HIV/AIDS or syphilis. The embedded study will use a mixed methods design including quantitative assessment of parent study participants with the Nottingham Onset Schedule-DUP to determine the DUP. Qualitative assessment will focus on patient and caregiver perceptions and use of ACT and its impact on DUP among patients with psychosis using in-depth interviews.Ethics and disseminationThe study has received ethical approval from the school of medicine research and ethics committee of the college of health sciences at Makerere University. It has also received institutional support to perform the study from the Infectious Diseases Institute and Butabika hospital. Besides publication of the work in reputable peer-reviewed journals, we hope that this work will lead to evidence-based discussions on the need for early interventions to reduce DUP in Uganda.

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