scholarly journals O9.1. PROSPECTIVE MEMORY AND THE RELATIONSHIP TO SOCIAL FUNCTION AND NEGATIVE SYMPTOMS IN CLINICAL HIGH RISK, FIRST EPISODE PSYCHOSIS, AND SCHIZOPHRENIA

2019 ◽  
Vol 45 (Supplement_2) ◽  
pp. S186-S187
Author(s):  
Anne Marie Teti ◽  
Patricia C Graham ◽  
Mallory Fergione ◽  
Lawrence C Haber ◽  
Joanna M Fiszdon ◽  
...  
Keyword(s):  
High Risk ◽  
Prospective Memory ◽  
Negative Symptoms ◽  
Social Function ◽  
First Episode Psychosis ◽  
First Episode ◽  
Clinical High Risk ◽  
Episode Psychosis ◽  
The Relationship

scholarly journals Dysregulation of complement and coagulation pathways: emerging mechanisms in the development of psychosis

2021 ◽  
Author(s):  
Meike Heurich ◽  
Melanie Föcking ◽  
David Mongan ◽  
Gerard Cagney ◽  
David R. Cotter
Keyword(s):  
High Risk ◽  
Psychotic Disorder ◽  
Psychotic Disorders ◽  
Clinical Symptoms ◽  
First Episode Psychosis ◽  
Specific Protein ◽  
First Episode ◽  
Clinical High Risk ◽  
Blood Proteins ◽  
Episode Psychosis

AbstractEarly identification and treatment significantly improve clinical outcomes of psychotic disorders. Recent studies identified protein components of the complement and coagulation systems as key pathways implicated in psychosis. These specific protein alterations are integral to the inflammatory response and can begin years before the onset of clinical symptoms of psychotic disorder. Critically, they have recently been shown to predict the transition from clinical high risk to first-episode psychosis, enabling stratification of individuals who are most likely to transition to psychotic disorder from those who are not. This reinforces the concept that the psychosis spectrum is likely a central nervous system manifestation of systemic changes and highlights the need to investigate plasma proteins as diagnostic or prognostic biomarkers and pathophysiological mediators. In this review, we integrate evidence of alterations in proteins belonging to the complement and coagulation protein systems, including the coagulation, anticoagulation, and fibrinolytic pathways and their dysregulation in psychosis, into a consolidated mechanism that could be integral to the progression and manifestation of psychosis. We consolidate the findings of altered blood proteins relevant for progression to psychotic disorders, using data from longitudinal studies of the general population in addition to clinical high-risk (CHR) individuals transitioning to psychotic disorder. These are compared to markers identified from first-episode psychosis and schizophrenia as well as other psychosis spectrum disorders. We propose the novel hypothesis that altered complement and coagulation plasma levels enhance their pathways’ activating capacities, while low levels observed in key regulatory components contribute to excessive activation observed in patients. This hypothesis will require future testing through a range of experimental paradigms, and if upheld, complement and coagulation pathways or specific proteins could be useful diagnostic or prognostic tools and targets for early intervention and preventive strategies.

Reduced P3a amplitudes in antipsychotic naïve first-episode psychosis patients and individuals at clinical high-risk for psychosis

2013 ◽  
Vol 47 (6) ◽  
pp. 755-761 ◽  
Author(s):  
Alejandra Mondragón-Maya ◽  
Rodolfo Solís-Vivanco ◽  
Pablo León-Ortiz ◽  
Yaneth Rodríguez-Agudelo ◽  
Guillermina Yáñez-Téllez ◽  
...  
Keyword(s):  
High Risk ◽  
First Episode Psychosis ◽  
First Episode ◽  
Clinical High Risk ◽  
Episode Psychosis

scholarly journals O8.4. CORTICAL DOPAMINE RELEASE IN RESPONSE TO A COGNITIVE CHALLENGE: PRELIMINARY RESULTS IN FIRST EPISODE PSYCHOSIS AND CLINICAL HIGH RISK

2019 ◽  
Vol 45 (Supplement_2) ◽  
pp. S184-S184
Author(s):  
Abanti Tagore ◽  
Naren Rao ◽  
Christin Schifani ◽  
Huai-Hsuan Tseng ◽  
Pablo Rusjan ◽  
...  
Keyword(s):  
High Risk ◽  
Dopamine Release ◽  
First Episode Psychosis ◽  
First Episode ◽  
Clinical High Risk ◽  
Preliminary Results ◽  
Episode Psychosis ◽  
Cognitive Challenge

scholarly journals 117.3 Imaging Microglial Activation in Clinical High Risk for Psychosis and Untreated First-Episode Psychosis: A PET StudyW [18F]FEPPA

2017 ◽  
Vol 43 (suppl_1) ◽  
pp. S64-S64 ◽  
Author(s):  
Romina Mizrahi ◽  
Sina Hafizi ◽  
Cory Gerritsen ◽  
Michael Kiang ◽  
Michael Bargby ◽  
...  
Keyword(s):  
High Risk ◽  
Microglial Activation ◽  
First Episode Psychosis ◽  
First Episode ◽  
Clinical High Risk ◽  
Episode Psychosis

Predictors of treatment response to psychological interventions in people at clinical high risk of first-episode psychosis

2017 ◽  
Vol 13 (1) ◽  
pp. 120-127 ◽  
Author(s):  
Helen Wessels ◽  
Michael Wagner ◽  
Kathrin Kuhr ◽  
Julia Berning ◽  
Verena Pützfeld ◽  
...  
Keyword(s):  
High Risk ◽  
Treatment Response ◽  
First Episode Psychosis ◽  
First Episode ◽  
Psychological Interventions ◽  
Clinical High Risk ◽  
Episode Psychosis

Toxic psychosis? Duration of untreated psychosis, symptomatology and cognitive deterioration in first episode psychosis

2007 ◽  
Vol 24 (4) ◽  
pp. 145-148 ◽  
Author(s):  
Richard Lawoyin ◽  
Keith Gaynor ◽  
Barbara Dooley ◽  
Elizabeth Lawlor ◽  
Mary Clarke ◽  
...  
Keyword(s):  
Negative Symptoms ◽  
First Episode Psychosis ◽  
First Episode ◽  
Positive Symptoms ◽  
Cognitive Deterioration ◽  
Duration Of Untreated Psychosis ◽  
Episode Psychosis ◽  
The Relationship ◽  
Linear Regressions ◽  
Positive And Negative Symptoms

AbstractObjectives: To examine the relationship between cognitive deficits, the duration of untreated psychosis (DUP) and positive and negative symptoms in a first episode psychosis sample.Method: We assessed a consecutive sample of first episode psychosis participants from a catchment area service with a comprehensive neuropsychology battery, a family and service-user based measure of DUP and measures of symptomatology.Results: Using correlations and stepwise linear regressions, we found strong relationships between measures of DUP and positive symptomatology. We found that positive and negative symptoms were associated with different time periods within DUP. However, we did not find evidence of a relationship between DUP and cognitive factors.Conclusions: There was no evidence of a relationship between DUP and cognitive deterioration. However, there does appear to be evidence of a relationship between positive symptoms and aspects of DUP. These results highlight the importance of the heterogeneity of DUP and the potential to reduce positive symptoms through early intervention.

Poster #T180 THE COURSE OF COGNITIVE FUNCTIONING IN CLINICAL HIGH RISK AND FIRST-EPISODE PSYCHOSIS INDIVIDUALS

2014 ◽  
Vol 153 ◽  
pp. S352-S353
Author(s):  
Martina Papmeyer ◽  
Erich Studerus ◽  
Marlon Pflüger ◽  
Sarah Ittig ◽  
Avinash Ramyead ◽  
...  
Keyword(s):  
High Risk ◽  
Cognitive Functioning ◽  
First Episode Psychosis ◽  
First Episode ◽  
Clinical High Risk ◽  
Episode Psychosis

scholarly journals Insight, duration of untreated psychosis and attachment in first-episode psychosis: prospective study of psychiatric recovery over 12-month follow-up

2014 ◽  
Vol 205 (1) ◽  
pp. 60-67 ◽  
Author(s):  
A. I. Gumley ◽  
M. Schwannauer ◽  
A. Macbeth ◽  
R. Fisher ◽  
S. Clark ◽  
...  
Keyword(s):  
Negative Symptoms ◽  
Attachment Security ◽  
First Episode Psychosis ◽  
Adult Attachment Interview ◽  
First Episode ◽  
Duration Of Untreated Psychosis ◽  
Episode Psychosis ◽  
The Relationship

BackgroundIncreasing evidence shows attachment security influences symptom expression and adaptation in people diagnosed with schizophrenia and other psychoses.AimsTo describe the distribution of secure and insecure attachment in a cohort of individuals with first-episode psychosis, and to explore the relationship between attachment security and recovery from positive and negative symptoms in the first 12 months.MethodThe study was a prospective 12-month cohort study. The role of attachment, duration of untreated psychosis (DUP), baseline symptoms and insight in predicting and mediating recovery from symptoms was investigated using multiple regression analysis and path analysis.ResultsOf the 79 participants, 54 completed the Adult Attachment Interview (AAI): 37 (68.5%) were classified as insecure, of which 26 (48.1%) were insecure/dismissing and 11 (20.4%) insecure preoccupied. Both DUP and insight predicted recovery from positive symptoms at 12 months. Attachment security, DUP and insight predicted recovery from negative symptoms at 12 months.ConclusionsAttachment is an important construct contributing to understanding and development of interventions promoting recovery following first-episode psychosis.

Do psychosis prodrome onset negative symptoms predict first presentation negative symptoms?

2014 ◽  
Vol 29 (3) ◽  
pp. 153-159 ◽  
Author(s):  
J. Lyne ◽  
L. Renwick ◽  
K. Madigan ◽  
B. O’Donoghue ◽  
M. Bonar ◽  
...  
Keyword(s):  
Negative Symptoms ◽  
Treatment Phase ◽  
First Episode Psychosis ◽  
Diagnostic Group ◽  
First Episode ◽  
Regression Analyses ◽  
Schizophrenia Spectrum ◽  
Episode Psychosis ◽  
Psychosis Prodrome ◽  
The Relationship

AbstractBackground:Negative symptoms have been previously reported during the psychosis prodrome, however our understanding of their relationship with treatment-phase negative symptoms remains unclear.Objectives:We report the prevalence of psychosis prodrome onset negative symptoms (PONS) and ascertain whether these predict negative symptoms at first presentation for treatment.Methods:Presence of expressivity or experiential negative symptom domains was established at first presentation for treatment using the Scale for Assessment of Negative Symptoms (SANS) in 373 individuals with a first episode psychosis. PONS were established using the Beiser Scale. The relationship between PONS and negative symptoms at first presentation was ascertained and regression analyses determined the relationship independent of confounding.Results:PONS prevalence was 50.3% in the schizophrenia spectrum group (n = 155) and 31.2% in the non-schizophrenia spectrum group (n = 218). In the schizophrenia spectrum group, PONS had a significant unadjusted (χ2 = 10.41, P < 0.001) and adjusted (OR = 2.40, 95% CI = 1.11–5.22, P = 0.027) association with first presentation experiential symptoms, however this relationship was not evident in the non-schizophrenia spectrum group. PONS did not predict expressivity symptoms in either diagnostic group.Conclusion:PONS are common in schizophrenia spectrum diagnoses, and predict experiential symptoms at first presentation. Further prospective research is needed to examine whether negative symptoms commence during the psychosis prodrome.

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