0300 Comparison of Sleep Disturbance and Quantitative Volumetric MRI Measures in Veterans With and Without History of Mild Traumatic Brain Injury (mTBI)

Objective This review aimed to determine the efficacy of blue-wavelength light therapy (BWLT) for post-traumatic brain injury (TBI) sleepiness, sleep disturbance, depression, and fatigue. Methods Pubmed, Scopus, Web of Science, Cochrane Library, Academic Search Complete, and CINAHL. Included trials were randomized controlled trials (RCTs) of BWLT in adults with a history of TBI. Outcomes of interest included sleepiness, sleep disturbance, depression, or fatigue. Two reviewers independently screened the searched items, selected the trials, extracted the data, and rating the quality of trials. We aggregated the data using a random-effect, frequentist network meta-analysis (NMA). Results We searched the databases on July 4, 2020. This review included four RCTs of 117 patients with a history of TBI who were randomized to received BWLT, amber light therapy (ALT), or no light therapy (NLT). Moderate-quality evidence revealed that: i) BWLT was significantly superior to NLT in reducing depression (SMD = 0.81, 95% CI = 0.20 to 1.43) ii) BWLT reduced fatigue at a significantly greater extent than NLT (SMD = 1.09, 95% CI = 0.41 to 1.76) and ALT (SMD = 1.00, 95% CI = 0.14 to 1.86). Low-quality evidence suggested that BWLT reduced depression at a greater extent than ALT (SMD = 0.57, 95% CI = 0.04 to 1.10). Low-quality evidence found that the dropout rates of those receiving BWLT and ALT were not significantly different (RR = 3.72, 95% CI = 0.65 to 21.34). Conclusion Moderate-quality evidence suggests that BWLT may be useful for post-TBI depression and fatigue.

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Pilot investigation of a novel white matter imaging technique in Veterans with and without history of mild traumatic brain injury

Brain Injury ◽

10.1080/02699052.2018.1493225 ◽

2018 ◽

Vol 32 (10) ◽

pp. 1255-1264 ◽

Cited By ~ 5

Author(s):

Sarah M. Jurick ◽

Samantha N. Hoffman ◽

Scott Sorg ◽

Amber V. Keller ◽

Nicole D. Evangelista ◽

...

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

White Matter ◽

Mild Traumatic Brain Injury ◽

Imaging Technique ◽

Pilot Investigation ◽

History Of

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Multimodal Neurocognitive Screening of Military Personnel With a History of Mild Traumatic Brain Injury Using the Bethesda Eye & Attention Measure

Journal of Head Trauma Rehabilitation ◽

10.1097/htr.0000000000000683 ◽

2021 ◽

Vol Publish Ahead of Print ◽

Author(s):

Mark L. Ettenhofer ◽

Lars D. Hungerford ◽

Stephanie Agtarap

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Mild Traumatic Brain Injury ◽

Military Personnel ◽

History Of

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A-108 Psychological and Sociodemographic Challenges, but Not History of Mild Traumatic Brain Injury, Is Associated with Criminal Justice Involvement among Veterans and Service Members

Archives of Clinical Neuropsychology ◽

10.1093/arclin/acab062.126 ◽

2021 ◽

Vol 36 (6) ◽

pp. 1157-1157

Author(s):

Becky Gius ◽

Lauren F Fournier ◽

Tea Reljic ◽

Terri Pogoda ◽

John Corrigan ◽

...

Keyword(s):

Social Support ◽

Traumatic Brain Injury ◽

Brain Injury ◽

Criminal Justice ◽

Alcohol Consumption ◽

Mild Traumatic Brain Injury ◽

Ptsd Symptoms ◽

Criminal Justice Involvement ◽

Lifetime History ◽

History Of

Abstract Objective Examine factors associated with history of arrests and felony incarceration among Veterans and Service Members (V/SM) with combat exposure. Method Participants were V/SM who completed a baseline assessment for the multicenter Chronic Effects of Neurotrauma Consortium study (N = 1555). Most were male (87%), white (72%), with a mean age of 40 years (SD = 9.71). The majority (83%) reported a history of ≥1 mild traumatic brain injury (mTBI), with thirty-five present of those experiencing 3+ mTBIs. Results Three groups were composed based on self-reported level of involvement with the criminal justice system: 1.) No history of arrests or incarcerations (65%), 2.) A lifetime history of arrest but no felony incarceration (32%), and 3.) A lifetime history of felony incarceration (3%). Chi-square and Kruskal-Wallis H tests revealed statistically significant differences between the groups in demographic factors including the incarcerated group having younger age, greater percentage of men, lower education, and greater percentage of never being married, followed by the arrest group and then the no arrest group (all p < 0.05). The incarcerated group also had the highest level of posttraumatic stress disorder (PTSD) symptoms, lowest social support, and greatest percentage of hazardous alcohol consumption, followed by the arrest and then the no arrest groups (all p < 0.05). No differences were found between groups for mTBI history or neuropsychological testing results. Conclusions Correlates of legal involvement among V/SM span demographic and psychological dimensions. Some correlates are modifiable, including social support, PTSD symptoms, and alcohol consumption. Addressing these modifiable risk factors is critical to lower the risk of future criminal justice involvement.

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The Natural History of Mild Traumatic Brain Injury

Manual of Traumatic Brain Injury ◽

10.1891/9781617052699.0008 ◽

2016 ◽

Author(s):

Grant L., Iverson ◽

Noah D., Silverberg ◽

Rael T. Lange

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Natural History ◽

Mild Traumatic Brain Injury ◽

History Of

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Insufficient Sleep Following Pediatric Mild Traumatic Brain Injury Correlates With Neurocognitive Dysfunction

Neurology ◽

10.1212/wnl.0000000000013046 ◽

2021 ◽

Vol 98 (1 Supplement 1) ◽

pp. S1.1-S1

Author(s):

Bailey Hull ◽

Patrick Karabon ◽

Neal Alpiner

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Sleep Disturbance ◽

Mild Traumatic Brain Injury ◽

Daytime Sleepiness ◽

Epworth Sleepiness Scale ◽

Neurocognitive Function ◽

Neurocognitive Dysfunction ◽

Neurocognitive Test ◽

Test Outcomes

ObjectiveAnalyze the impact of sleep disturbance on neurocognitive function in children recovering from mild traumatic brain injury (mTBI).BackgroundSleep disturbance of any nature is reported in more than half of all mTBI patients. The pathophysiology of sleep disturbance following mTBI is associated with structural and functional disruptions of sleep circuitry and circadian rhythm. Specifically in the pediatric population, untreated sleep disturbance has been shown to delay mTBI recovery and compound other morbidities including neurocognitive dysfunction.Design/MethodsA retrospective chart review of 118 pediatric patients (mean age = 14.56 ± 2.03 years) recovering from mTBI was performed. Epworth Sleepiness Scale (SF-8) results were analyzed in relation to CNS Vital Signs (CNSVS) neurocognitive test outcomes. SF-8 is a subjective estimation of a patient's daytime sleepiness. CNSVS uses a multitude of domains to objectively evaluate the overall neurocognitive status of a patient. Pearson correlations were calculated using a type I error of p < 0.05 between variables.ResultsEpworth Sleepiness Scale (SF-8) results showed 28.82% of participants experienced excessive daytime sleepiness sufficient enough to recommend medical attention. Upon further analysis, there was a significant negative correlation between SF-8 and CNSVS neurocognitive test outcomes including complex attention (r = −0.37; p = 0.0004), cognitive flexibility (r = −0.24; p = 0.0151), executive function (r = −0.21; p = 0.0350), and simple attention (r = −0.36; p = 0.0003) scores. This means as SF-8 scores increased (participants defined as excessively sleepy), neurocognitive function scores in these domains decreased. There was not enough evidence to conclude a significant correlation between other CNSVS domains and SF-8 (all p > 0.05).ConclusionsOur findings support the concern of neurocognitive dysfunction among pediatric mTBI patients with sleep disturbance. Further analysis is needed to determine if mTBI is the primary source or an exacerbating factor of sleep disturbance within this population. Nonetheless, these findings suggest a need for thorough evaluation when treating sleep concerns, irrespective of a history of childhood mTBI.

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