Blue-wavelength light therapy for post-traumatic brain injury sleepiness, sleep disturbance, depression, and fatigue: A systematic review and network meta-analysis

Objective This review aimed to determine the efficacy of blue-wavelength light therapy (BWLT) for post-traumatic brain injury (TBI) sleepiness, sleep disturbance, depression, and fatigue. Methods Pubmed, Scopus, Web of Science, Cochrane Library, Academic Search Complete, and CINAHL. Included trials were randomized controlled trials (RCTs) of BWLT in adults with a history of TBI. Outcomes of interest included sleepiness, sleep disturbance, depression, or fatigue. Two reviewers independently screened the searched items, selected the trials, extracted the data, and rating the quality of trials. We aggregated the data using a random-effect, frequentist network meta-analysis (NMA). Results We searched the databases on July 4, 2020. This review included four RCTs of 117 patients with a history of TBI who were randomized to received BWLT, amber light therapy (ALT), or no light therapy (NLT). Moderate-quality evidence revealed that: i) BWLT was significantly superior to NLT in reducing depression (SMD = 0.81, 95% CI = 0.20 to 1.43) ii) BWLT reduced fatigue at a significantly greater extent than NLT (SMD = 1.09, 95% CI = 0.41 to 1.76) and ALT (SMD = 1.00, 95% CI = 0.14 to 1.86). Low-quality evidence suggested that BWLT reduced depression at a greater extent than ALT (SMD = 0.57, 95% CI = 0.04 to 1.10). Low-quality evidence found that the dropout rates of those receiving BWLT and ALT were not significantly different (RR = 3.72, 95% CI = 0.65 to 21.34). Conclusion Moderate-quality evidence suggests that BWLT may be useful for post-TBI depression and fatigue.

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Blue-wavelength Light Therapy for Post-traumatic Brain Injury Sleepiness, Sleep Disturbance, Depression, Fatigue: A Systematic Review and Network Meta-analysis

10.21203/rs.3.rs-58112/v1 ◽

2020 ◽

Author(s):

Karan Srisurapan ◽

Yanisa Samakarn ◽

Boonyasit Kamklong ◽

Phichayakan Siratrairat ◽

Arina Bumiputra ◽

...

Keyword(s):

Systematic Review ◽

Sleep Disturbance ◽

Meta Analysis ◽

Light Therapy ◽

Controlled Trials ◽

Amber Light ◽

Randomized Controlled ◽

Blue Wavelength ◽

Post Traumatic ◽

Wavelength Light

Abstract Background: We aimed to determine the efficacy of blue-wavelength light therapy (BWLT) for post-traumatic brain injury (TBI) sleepiness, sleep disturbance, depression, and fatigue.Methods: We searched six databases for randomized controlled trials of BWLT for adults with a history of TBI. Outcomes of interest included sleepiness, sleep disturbance, depression, or fatigue. We conducted random-effect frequentist network meta-analyses (NMA) to compare the efficacy and a pairwise meta-analysis to examine the dropout rates.Results: We included four randomized controlled trials that compared BWLT, amber light therapy, and no light therapy. BWLT was significantly superior in reducing depression as compared to amber light therapy (SMD = 0.57, 95% CI = 0.04 to 1.10) and no light therapy (SMD = 0.81, 95% CI = 0.20 to 1.43). BWLT was also significantly superior in reducing fatigue as compared to amber light therapy (SMD = 1.00, 95% CI = 0.14 to 1.86) and no light therapy (SMD = 1.09, 95% CI = 0.41 to 1.76). There was no significant heterogeneity of depression and fatigue data (I2 = 0% for both). The relative risk of dropout rates (95% CI) shows no significant difference between BWLT and amber light therapy groups (RR = 3.72, 95% CI = 0.66 to 21.34, I2 = 0%).Conclusion: BWLT may be effective for post-TBI depression and fatigue. Due to the risks of bias and the inability to exclude publication bias among included studies, the current evidence remains insufficient to support the clinical application of BWLT for post-TBI depression and fatigue. Protocol registration: The protocol of this systematic review is available at Open Science Framework (https://osf.io/yf2qe/).

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1171 SHORT-WAVELENGTH LIGHT THERAPY AS A WAY OF IMPROVING SLEEP, COGNITION, AND FUNCTIONAL CONNECTIVITY FOLLOWING A MILD TRAUMATIC BRAIN INJURY

SLEEP ◽

10.1093/sleepj/zsx050.1170 ◽

2017 ◽

Vol 40 (suppl_1) ◽

pp. A437-A437

Author(s):

JR Vanuk ◽

BR Shane ◽

S Bajaj ◽

M Millan ◽

M Grandner ◽

...

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Functional Connectivity ◽

Mild Traumatic Brain Injury ◽

Short Wavelength ◽

Light Therapy ◽

Short Wavelength Light ◽

Wavelength Light

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Economies of Post-Traumatic Stress Disorder and Traumatic Brain Injury

Figuring Violence ◽

10.5422/fordham/9780823281671.003.0005 ◽

2018 ◽

pp. 137-177

Author(s):

Rebecca A. Adelman

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Combat Trauma ◽

Post Traumatic Stress ◽

Charitable Organizations ◽

Domestic Spaces ◽

Non Fiction ◽

The People ◽

History Of ◽

Post Traumatic

This chapter explores the mediation of combat trauma and the reshaping of the people who have experienced it into receptacles for gratitude, pity, and anger. Building from a brief history of PTSD and TBI as diagnostic categories and objects of administrative calculation, the chapter explores how these conditions have become sites of affective investment. Reflecting on the ubiquitous mandate to ‘say thank you to the troops,’ the chapter historicizes the militarization of gratitude. This informs the subsequent analysis of the work of various charitable organizations for veterans. The chapter then analyzes the exacting standards by which the Department of Defense awards Purple Hearts for Traumatic Brain Injury (but refuses them for PTSD). In contrast to the DoD’s decidedly unsympathetic approach to PTSD, David Finkel’s bestselling non-fiction account Thank You for Your Service tracks how PTSD plays out, often violently, in domestic spaces. That book makes PTSD visible through intensely emotional scenes, while research efforts to make TBI clinically legible search for specific signs of the injury on posthumously donated brain tissue. The concluding section offers a different vantage on TBI, reflecting on veterans’ own efforts to make their brains visible to others.

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Incidence of post-traumatic hydrocephalus in traumatic brain injury patients that underwent DC versus those that were managed without DC: A systematic review and meta-analysis

Brain and Spine ◽

10.1016/j.bas.2021.100303 ◽

2021 ◽

Vol 1 ◽

pp. 100303

Author(s):

Georgios Mavrovounis ◽

Adamantios Kalogeras ◽

Alexandros Brotis ◽

Corrado Iaccarino ◽

Andreas K. Demetriades ◽

...

Keyword(s):

Systematic Review ◽

Traumatic Brain Injury ◽

Brain Injury ◽

Meta Analysis ◽

Post Traumatic

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Factors Associated With Response to Pilot Home-Based Light Therapy for Fatigue Following Traumatic Brain Injury and Stroke

Frontiers in Neurology ◽

10.3389/fneur.2021.651392 ◽

2021 ◽

Vol 12 ◽

Author(s):

Laura J. Connolly ◽

Shantha M. W. Rajaratnam ◽

Gershon Spitz ◽

Steven W. Lockley ◽

Jennie L. Ponsford

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Sleep Quality ◽

Sleep Disturbance ◽

Primary Outcome ◽

Mixed Model ◽

Linear Mixed Model ◽

Injury Severity ◽

Light Therapy ◽

Productive Activity

Background: Fatigue and sleep disturbance are common and debilitating problems after brain injury. Light therapy shows promise as a potential treatment. We conducted a trial of in-home light therapy to alleviate fatigue and sleep disturbance. The aim of the current study was to identify factors moderating treatment response.Methods: Participants were 24 individuals with traumatic brain injury (TBI) (n = 19) or stroke (n = 5) reporting clinically significant fatigue. Outcomes included fatigue on Brief Fatigue Inventory (primary outcome), sleep disturbance on Pittsburgh Sleep Quality Index, reaction time (RT) on Psychomotor Vigilance Task and time spent in productive activity. Interactions of demographic and clinical variables with these outcomes were examined in linear mixed-model analyses.Results: Whilst there were no variables found to be significantly associated with change in our primary outcome of fatigue, some variables revealed medium or large effect sizes, including chronotype, eye color, injury severity as measured by PTA, and baseline depressive symptoms. Chronotype significantly moderated sleep quality, with evening chronotype being associated with greater improvement during treatment. Injury type significantly predicted mean RT, with stroke participants exhibiting greater post-treatment reduction than TBI. Age significantly predicted productive activity during Treatment, with younger participants showing stronger Treatment effect.Conclusion: Light therapy may have a greater impact on sleep in younger individuals and those with an evening chronotype. Older individuals may need higher treatment dose to achieve benefit.Clinical Trial Registration:www.anzctr.org.au, identifier: ACTRN12617000866303.

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