scholarly journals 0861 The Relationship between Continuous Positive Airway PressureTreatment in Obstructive Sleep Apnea SyndromePatients and Sensorineural Hearing Loss: A Prospective Cohort Study

SLEEP ◽  
2019 ◽  
Vol 42 (Supplement_1) ◽  
pp. A345-A346
Author(s):  
Jessie Chao-Yun Chi ◽  
Ting Hua ◽  
Stanley Yung Liu
Keyword(s):  
Obstructive Sleep Apnea ◽  
Hearing Loss ◽  
Cohort Study ◽  
Sleep Apnea ◽  
Sensorineural Hearing Loss ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Sensorineural Hearing ◽  
Obstructive Sleep ◽  
The Relationship

scholarly journals Prognostic factors for outcomes of idiopathic sudden sensorineural hearing loss: protocol for the SeaSHeL national prospective cohort study

BMJ Open ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. e038552
Author(s):  
Rishi Mandavia ◽  
Gerjon Hannink ◽  
Muhammad Nayeem Ahmed ◽  
Yaami Premakumar ◽  
Timothy Shun Man Chu ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Cohort Study ◽  
Sensorineural Hearing Loss ◽  
Prospective Cohort Study ◽  
Health Research ◽  
Prospective Cohort ◽  
Prognostic Model ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Adult Patients

IntroductionThe mainstay of treatment for idiopathic sudden sensorineural hearing loss (SSNHL) includes oral steroids, intratympanic steroid injections or a combination of both. The National Institute for Health and Care Excellence, in their recent hearing loss guidelines, highlighted the paucity of evidence assessing the comparative effectiveness of these treatments; and the National Institute for Health Research (NIHR) Health Technology Assessment Programme has since released a commissioned call for a trial to identify the most effective route of administration of steroids as a first-line treatment for idiopathic SSNHL. For such trials to be run effectively, reliable information is needed on patients with SSNHL: where they present, numbers, demographics, treatment pathways, as well as outcomes. This study will collect these data in a nationwide cohort study of patients presenting with SSNHL across 97 National Health Service (NHS) trusts. The study will be delivered through ear, nose and throat (ENT) trainee networks, the NIHR Clinical Research Network (CRN) Audiology Champions and the NIHR CRN. Importantly, this study will also provide a dataset to develop a prognostic model to predict recovery for patients with idiopathic SSNHL. The study objectives are to: (1) map the patient pathway and identify the characteristics of adult patients presenting to NHS ENT and hearing services with SSNHL, (2) develop a prognostic model to predict recovery for patients with idiopathic SSNHL and (3) establish the impact of idiopathic SSNHL on patients’ quality of life (QoL).Methods and analysisStudy design: national multicentre prospective cohort study across 97 NHS trusts.Inclusion criteria: adult patients presenting to NHS ENT and hearing services with SSNHL.Outcomes: change in auditory function; change in QoL score.Analysis: multivariable prognostic model, using prespecified candidate predictors. Mean change in QoL scores will be calculated from initial presentation to follow-up.Ethics and disseminationHealth Research Authority and NHS Research Ethics Committee approved the study. Publication will be on behalf of study sites and collaborators.Trial registration numberClinicalTrials.gov Registry (NCT04108598).

scholarly journals ENT Manifestations of Celiac Disease: A Scholarly Review

2020 ◽  
pp. 014556132097260
Author(s):  
Dilhara Karunaratne ◽  
Nisal Karunaratne
Keyword(s):  
Obstructive Sleep Apnea ◽  
Hearing Loss ◽  
Celiac Disease ◽  
Sleep Apnea ◽  
Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Septal Perforation ◽  
Nasal Septal Perforation ◽  
Obstructive Sleep ◽  
Pubmed Database

Objectives: Celiac disease is a common multisystemic autoimmune disorder. It is now increasingly recognized that it may present with extraintestinal manifestations which contribute to the difficulty in its diagnosis. The objective of this scholarly review was to examine the extraintestinal ENT manifestations of celiac disease and its pathophysiology and management, in order to highlight that some patients with celiac disease may present initially to the otolaryngologist. Improving awareness of celiac disease among otolaryngologists may aid in the correct diagnosis and correct management plan. Methods: A literature review was conducted using the PubMed database to identify original articles related to celiac disease and ENT manifestations between the years 2000 and 2020. The search was performed using the search string: (“coeliac disease” OR “celiac disease”) AND (“ENT manifestations” OR “hearing loss” OR “epistaxis” OR “nasal septal perforation” OR “obstructive sleep apnoea” OR “vertigo” OR “tonsillitis” OR “sinusitis”). Only articles written in English were reviewed. Results: A total of 17 papers met the inclusion criteria. Extraintestinal ENT manifestations of celiac disease include sensorineural hearing loss, obstructive sleep apnea, nasal septal perforation, epistaxis, and vertigo with nystagmus. Sensorineural hearing loss, obstructive sleep apnea, nasal septal perforation, vertigo, and nystagmus are thought to result from immunologically mediated mechanisms, with intestinal malabsorption resulting in epistaxis. Conclusions: Celiac disease can cause extraintestinal ENT manifestations and requires a high index of suspicion from the otolaryngologist to diagnose and suitably manage. A gluten-free diet may result in sufficient symptom resolution for most manifestations. Sensorineural hearing loss due to celiac disease appears to be progressive and permanent and may require frequent audiological monitoring.

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