scholarly journals Three-Generation Reproductive Toxicity Study of Dietary Bisphenol A in CD Sprague-Dawley Rats

2002 ◽  
Vol 68 (1) ◽  
pp. 121-146 ◽  
Author(s):  
R. W. Tyl
Keyword(s):  
Bisphenol A ◽  
Reproductive Toxicity ◽  
Toxicity Study ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

One-generation reproductive toxicity study of epichlorohydrin in Sprague-Dawley rats

2010 ◽  
Vol 33 (3) ◽  
pp. 291-301 ◽  
Author(s):  
In-Sik Shin ◽  
Na-Hyeong Park ◽  
Jong-Chan Lee ◽  
Kang-Hyeon Kim ◽  
Changjong Moon ◽  
...  
Keyword(s):  
Reproductive Toxicity ◽  
Toxicity Study ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals A two-generation reproductive toxicity study of sodium molybdate dihydrate administered in drinking water or diet to Sprague-Dawley rats

2019 ◽  
Vol 84 ◽  
pp. 75-92
Author(s):  
F. Jay Murray ◽  
Frank M. Sullivan ◽  
Sue A. Hubbard ◽  
Alan M. Hoberman ◽  
Sandra Carey
Keyword(s):  
Drinking Water ◽  
Reproductive Toxicity ◽  
Sodium Molybdate ◽  
Toxicity Study ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Effects of endocrine disruptor furan on reproductive physiology of Sprague Dawley rats: An F1 Extended One-Generation Reproductive Toxicity Study (EOGRTS)

2020 ◽  
Vol 39 (8) ◽  
pp. 1079-1094 ◽  
Author(s):  
H Rehman ◽  
S Jahan ◽  
I Ullah ◽  
P-O Thörnqvist ◽  
M Jabbar ◽  
...  
Keyword(s):  
Reproductive Toxicity ◽  
Head Tilt ◽  
Treated Group ◽  
Toxicity Study ◽  
Female Rats ◽  
Male Rats ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Estrous Cyclicity ◽  
F1 Generation

The present study investigated the reproductive toxicity of furan in an Extended One-Generation Reproductive Toxicity Study in rats. Sprague Dawley F0 weaning rats (30 per sex per group) were exposed to furan orally at 0, 1, 2.5, 5, and 10 mg kg−1 for 10 weeks (males) and 2 weeks (females) and then mated. Results of F0 indicated that in the furan-treated groups (5 mg kg−1 and 10 mg kg−1), body weight (bw) gain decreased during prebreed and gestational period while increased during lactation periods. F0 animals prebreeding exposure resulted in head tilt and foot splay at 10 mg kg−1. Number of live pups at birth were decreased ( p < 0.001) at 10 mg kg−1. At postnatal day (PND) 70, a significant ( p = 0.03) decrease in testosterone levels of male rats and estrogen levels of female rats ( p = 0.05) was observed in 10 mg kg−1 furan-treated group in F1 generation. Luteinizing hormone, follicle-stimulating hormone, and progesterone levels were also reduced, but their reduction was not statistically significant in all groups. In higher dose furan group (10 mg kg−1), testicular and ovarian weights were reduced in F1 generation at PND 70, with decreased daily sperm production ( p = 0.01) and disturbed estrous cyclicity ( p < 0.01). Some histopathological changes were also observed in testis and ovaries in groups whose parents were previously exposed to 10 mg kg−1 bw of furan group. Based on the above results, it is suggested that exposure to food-based contaminant furan induced remarkable changes in the F0 (parental stage) and F1 (offspring, pubertal, and adult stage) generations of Sprague Dawley rats.

3-Week repeated oral dose toxicity study of bisphenol a in juvenile Sprague-Dawley rats with toxicokinetics

2017 ◽  
Vol 72 ◽  
pp. 39 ◽  
Author(s):  
Ji Seong Jeong ◽  
Aryo Dimas Pamungkas ◽  
Daeun Song ◽  
Minjeong Kim ◽  
Wook-Joon Yu ◽  
...  
Keyword(s):  
Oral Dose ◽  
Bisphenol A ◽  
Toxicity Study ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

One-generation reproductive toxicity study of 2-methylbutane in Sprague–Dawley rats

2011 ◽  
Vol 60 (1) ◽  
pp. 136-143 ◽  
Author(s):  
Wook-Joon Yu ◽  
Moon-Koo Chung ◽  
Yong-Hyun Chung ◽  
Hyoung-Chin Kim ◽  
Sung-Hwan Kim ◽  
...  
Keyword(s):  
Reproductive Toxicity ◽  
Toxicity Study ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Ipomoea batatas Tuber Efficiency on Bisphenol A-induced Male Reproductive Toxicity in Sprague Dawley Rats

2017 ◽  
Vol 7 (2) ◽  
pp. 118-130
Author(s):  
Rajendiran Revathy ◽  
Kulanthaivel Langeswaran ◽  
Rajagopal Ponnulakshmi ◽  
Maduraiveeran Periyasamy Balasubramanian ◽  
Jayaraman Selvaraj
Keyword(s):  
Bisphenol A ◽  
Ipomoea Batatas ◽  
Reproductive Toxicity ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Acute Toxicity of Administered Bisphenol A Di Glycidyl Ether in Male Sprague Dawley Rats

2006 ◽  
Vol 18 (4) ◽  
pp. 318 ◽  
Author(s):  
Jae un Im ◽  
Yun jung Yang ◽  
Tae jin Lee ◽  
Yeon pyo Hong
Keyword(s):  
Acute Toxicity ◽  
Bisphenol A ◽  
Glycidyl Ether ◽  
Sprague Dawley ◽  
Sprague Dawley Rats
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