3-Week repeated oral dose toxicity study of bisphenol a in juvenile Sprague-Dawley rats with toxicokinetics

2017 ◽  
Vol 72 ◽  
pp. 39 ◽  
Author(s):  
Ji Seong Jeong ◽  
Aryo Dimas Pamungkas ◽  
Daeun Song ◽  
Minjeong Kim ◽  
Wook-Joon Yu ◽  
...  
Keyword(s):  
Oral Dose ◽  
Bisphenol A ◽  
Toxicity Study ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

A 4-week repeated oral dose toxicity study of fucoidan from the Sporophyll of Undaria pinnatifida in Sprague–Dawley rats

Toxicology ◽  
2010 ◽  
Vol 267 (1-3) ◽  
pp. 154-158 ◽  
Author(s):  
Kui-Jin Kim ◽  
Ok-Hwan Lee ◽  
Hee-Hyun Lee ◽  
Boo-Yong Lee
Keyword(s):  
Oral Dose ◽  
Undaria Pinnatifida ◽  
Toxicity Study ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

26-Week repeated oral dose toxicity study of the new quinolone antibacterial DW-116 in Sprague–Dawley rats

2003 ◽  
Vol 41 (5) ◽  
pp. 637-645 ◽  
Author(s):  
J-C Kim ◽  
D-H Shin ◽  
T-H Ahn ◽  
S-S Kang ◽  
S-W Song ◽  
...  
Keyword(s):  
Oral Dose ◽  
Toxicity Study ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals Thirteen-Week Oral Dose Toxicity Study of G. bimaculatus in Sprague-Dawley Rats

2011 ◽  
Vol 27 (4) ◽  
pp. 231-240 ◽  
Author(s):  
Mi-Young Ahn ◽  
Jea-Woong Han ◽  
Soon-Ja Kim ◽  
Jae-Sam Hwang ◽  
Eun-Young Yun
Keyword(s):  
Oral Dose ◽  
Toxicity Study ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals 13-Week repeated oral dose toxicity study on mixture of Korean red ginseng and deer antler extract in Sprague-Dawley rats

2019 ◽  
Vol 36 (1) ◽  
pp. 1-12
Author(s):  
Jae Hyun Suh ◽  
Hwi Won Seo ◽  
Byung-Cheol Han ◽  
Jong-Soo Kyung ◽  
Seung-Ho So
Keyword(s):  
Oral Dose ◽  
Toxicity Study ◽  
Red Ginseng ◽  
Sprague Dawley ◽  
Deer Antler ◽  
Korean Red Ginseng ◽  
Sprague Dawley Rats

Acute Toxicity of Administered Bisphenol A Di Glycidyl Ether in Male Sprague Dawley Rats

2006 ◽  
Vol 18 (4) ◽  
pp. 318 ◽  
Author(s):  
Jae un Im ◽  
Yun jung Yang ◽  
Tae jin Lee ◽  
Yeon pyo Hong
Keyword(s):  
Acute Toxicity ◽  
Bisphenol A ◽  
Glycidyl Ether ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals Oral absorption and drug interaction kinetics of moxifloxacin in an animal model of weightlessness

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Dong Liang ◽  
Jing Ma ◽  
Bo Wei
Keyword(s):  
Oral Dose ◽  
Oral Absorption ◽  
Jugular Vein ◽  
Plasma Concentrations ◽  
Pharmacokinetic Data ◽  
Simulated Weightlessness ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Interaction Kinetics ◽  
Kinetics Of

AbstractTo investigate the effect of simulated weightlessness on the pharmacokinetics of orally administered moxifloxacin and the antacid Maalox or the antidiarrheal Pepto-Bismol using a tail-suspended (TS) rat model of microgravity. Fasted control and TS, jugular-vein-cannulated, male Sprague-Dawley rats received either a single 5 mg/kg intravenous dose or a single 10 mg/kg oral dose of moxifloxacin alone or with a 0.625 mL/kg oral dose of Maalox or a 1.43 mL/kg oral dose of Pepto-Bismol. Plasma concentrations of moxifloxacin were measured by HPLC. Pharmacokinetic data were analyzed using WinNonlin. Simulated weightlessness had no effect on moxifloxacin disposition after intravenous administration but significantly decreased the extent of moxifloxacin oral absorption. The coadministration of moxifloxacin with Maalox to either control or TS rats caused significant reductions in the rate and extent of moxifloxacin absorption. In contrast, the coadministration of moxifloxacin with Pepto-Bismol to TS rats had no significant effect on either the rate or the extent of moxifloxacin absorption. These interactions showed dose staggering when oral administrations of Pepto-Bismol and moxifloxacin were separated by 60 min in control rats but not in TS rats. Dose staggering was more apparent after the coadministration of Maalox and moxifloxacin in TS rats.

scholarly journals Assessment of General Toxicity of the Glycyrrhiza New Variety Extract in Rats

Plants ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1126
Author(s):  
Dong-Gu Kim ◽  
Jeonghoon Lee ◽  
Wonnam Kim ◽  
Hyo-Jin An ◽  
Jong-Hyun Lee ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Oral Dose ◽  
Toxicity Study ◽  
Sprague Dawley ◽  
New Variety ◽  
General Toxicity ◽  
Normal Ranges ◽  
Target Organs ◽  
Adverse Effect Level ◽  
Tract Infections

The Glycyrrhiza radix (Licorice) is one of the most commonly used medicinal plants in Asian countries, such as China, India, and Korea. It has been traditionally used to treat many diseases, including cough, cold, asthma, fatigue, gastritis, and respiratory tract infections. A Glycyrrhiza new variety, Wongam (WG), has been developed by the Korea Rural Development Administration and revealed pharmacological effects. However, the potential adverse effects of WG have not been revealed yet. This study evaluates the general toxicity of the WG extract through a single and repeated oral dose toxicity study in Sprague-Dawley rats. After single oral dose administration, no significant toxicological changes or mortality was observed up to 5000 mg/kg. Over a 4-week repeated oral dose toxicity study, no adverse effects and target organs were observed up to 5000 mg/kg/day. Over a 13-week repeated oral dose toxicity study, no mortality or toxicological changes involving ophthalmology, water consumption, or hematology were observed up to 5000 mg/kg/day. Although other parameters were changed, the alterations in question were not considered toxicologically significant, since responses remained within normal ranges and were not dose-dependent. In conclusion, the no-observed-adverse-effect level (NOAEL) of WG was higher than 5000 mg/kg/day, and no target organs were identified in rats.

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