scholarly journals Two-generation Reproductive Toxicity Study of Barrisal (Herbal Drug) on the Sprague Dawley Rats

2014 ◽  
Vol 4 (21) ◽  
pp. 3197-3202
Author(s):  
Muhammad Ahmed
Keyword(s):  
Reproductive Toxicity ◽  
Toxicity Study ◽  
Herbal Drug ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

One-generation reproductive toxicity study of epichlorohydrin in Sprague-Dawley rats

2010 ◽  
Vol 33 (3) ◽  
pp. 291-301 ◽  
Author(s):  
In-Sik Shin ◽  
Na-Hyeong Park ◽  
Jong-Chan Lee ◽  
Kang-Hyeon Kim ◽  
Changjong Moon ◽  
...  
Keyword(s):  
Reproductive Toxicity ◽  
Toxicity Study ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals A two-generation reproductive toxicity study of sodium molybdate dihydrate administered in drinking water or diet to Sprague-Dawley rats

2019 ◽  
Vol 84 ◽  
pp. 75-92
Author(s):  
F. Jay Murray ◽  
Frank M. Sullivan ◽  
Sue A. Hubbard ◽  
Alan M. Hoberman ◽  
Sandra Carey
Keyword(s):  
Drinking Water ◽  
Reproductive Toxicity ◽  
Sodium Molybdate ◽  
Toxicity Study ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Effects of endocrine disruptor furan on reproductive physiology of Sprague Dawley rats: An F1 Extended One-Generation Reproductive Toxicity Study (EOGRTS)

2020 ◽  
Vol 39 (8) ◽  
pp. 1079-1094 ◽  
Author(s):  
H Rehman ◽  
S Jahan ◽  
I Ullah ◽  
P-O Thörnqvist ◽  
M Jabbar ◽  
...  
Keyword(s):  
Reproductive Toxicity ◽  
Head Tilt ◽  
Treated Group ◽  
Toxicity Study ◽  
Female Rats ◽  
Male Rats ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Estrous Cyclicity ◽  
F1 Generation

The present study investigated the reproductive toxicity of furan in an Extended One-Generation Reproductive Toxicity Study in rats. Sprague Dawley F0 weaning rats (30 per sex per group) were exposed to furan orally at 0, 1, 2.5, 5, and 10 mg kg−1 for 10 weeks (males) and 2 weeks (females) and then mated. Results of F0 indicated that in the furan-treated groups (5 mg kg−1 and 10 mg kg−1), body weight (bw) gain decreased during prebreed and gestational period while increased during lactation periods. F0 animals prebreeding exposure resulted in head tilt and foot splay at 10 mg kg−1. Number of live pups at birth were decreased ( p < 0.001) at 10 mg kg−1. At postnatal day (PND) 70, a significant ( p = 0.03) decrease in testosterone levels of male rats and estrogen levels of female rats ( p = 0.05) was observed in 10 mg kg−1 furan-treated group in F1 generation. Luteinizing hormone, follicle-stimulating hormone, and progesterone levels were also reduced, but their reduction was not statistically significant in all groups. In higher dose furan group (10 mg kg−1), testicular and ovarian weights were reduced in F1 generation at PND 70, with decreased daily sperm production ( p = 0.01) and disturbed estrous cyclicity ( p < 0.01). Some histopathological changes were also observed in testis and ovaries in groups whose parents were previously exposed to 10 mg kg−1 bw of furan group. Based on the above results, it is suggested that exposure to food-based contaminant furan induced remarkable changes in the F0 (parental stage) and F1 (offspring, pubertal, and adult stage) generations of Sprague Dawley rats.

One-generation reproductive toxicity study of 2-methylbutane in Sprague–Dawley rats

2011 ◽  
Vol 60 (1) ◽  
pp. 136-143 ◽  
Author(s):  
Wook-Joon Yu ◽  
Moon-Koo Chung ◽  
Yong-Hyun Chung ◽  
Hyoung-Chin Kim ◽  
Sung-Hwan Kim ◽  
...  
Keyword(s):  
Reproductive Toxicity ◽  
Toxicity Study ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Safety Assessment of a Hydroethanolic Extract of Caralluma fimbriata

2013 ◽  
Vol 32 (5) ◽  
pp. 385-394 ◽  
Author(s):  
Antoinette Y. Odendaal ◽  
Narendra S. Deshmukh ◽  
Tennille K. Marx ◽  
Alexander G. Schauss ◽  
John R. Endres ◽  
...  
Keyword(s):  
Developmental Toxicity ◽  
Toxicity Study ◽  
Developmental Study ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Toxicological Assessment ◽  
Sprague Dawley Rats ◽  
Chromosomal Aberration Test ◽  
Hydroethanolic Extract

This toxicological assessment evaluated the safety of a hydroethanolic extract prepared from Caralluma fimbriata (CFE), a dietary supplement marketed worldwide as an appetite suppressant. Studies included 2 in vitro genotoxicity assays, a repeated dose oral toxicity study, and a developmental study in rats. No evidence of in vitro mutagenicity or clastogenicity surfaced in the in vitro studies at concentrations up to 5000 μg of extract/plate (Ames test) or 5000 μg of extract/mL (chromosomal aberration test). No deaths or treatment-related toxicity were seen in the 6-month chronic oral toxicity study in Sprague-Dawley rats conducted at 3 doses (100, 300, and 1000 mg/kg body weight (bw)/d). The no observed effect level for CFE in this study was considered to be 1000 mg/kg bw/d. A prenatal developmental toxicity study conducted at 3 doses (250, 500, and 1000 mg/kg bw/d) in female Sprague-Dawley rats resulted in no treatment-related external, visceral, or skeletal fetal abnormalities, and no treatment-related maternal or pregnancy alterations were seen at and up to the maximum dose tested. CFE was not associated with any toxicity or adverse events.

90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats

2021 ◽  
pp. 112780
Author(s):  
Shu-Chieh Hu ◽  
Seonggi Min ◽  
Hyun-Ki Kang ◽  
Dong-Jin Yang ◽  
Mallikarjuna Basavarajappa ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Inhalation Toxicity ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals Acute Toxicity Study of Standardized Mitragyna speciosa Korth Aqueous Extract in Sprague Dawley Rats

2012 ◽  
Vol 1 (2) ◽  
Author(s):  
Mohd Saleh Ahmad Kamal ◽  
Ahmad Rohi Ghazali ◽  
Noral ‘Ashikin Yahya ◽  
Mohd Isa Wasiman ◽  
Zakiah Ismail
Keyword(s):  
Acute Toxicity ◽  
Aqueous Extract ◽  
Toxicity Study ◽  
Sprague Dawley ◽  
Mitragyna Speciosa ◽  
Acute Toxicity Study ◽  
Sprague Dawley Rats

4-Week repeated dose oral toxicity study of N-ethyl-2-pyrrolidone in Sprague Dawley rats

2016 ◽  
Vol 81 ◽  
pp. 275-283 ◽  
Author(s):  
A.M. Saillenfait ◽  
F. Marquet ◽  
J.P. Sabaté ◽  
D. Ndiaye ◽  
A.M. Lambert-Xolin
Keyword(s):  
Toxicity Study ◽  
Repeated Dose ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Sprague Dawley Rats ◽  
Dose Oral
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