scholarly journals Metallothionein-III Provides Neuronal Protection through Activation of Nuclear Factor-κB via the TrkA/Phosphatidylinositol-3 kinase/Akt Signaling Pathway

2009 ◽  
Vol 112 (2) ◽  
pp. 435-449 ◽  
Author(s):  
Hyung Gyun Kim ◽  
Yong Pil Hwang ◽  
Eun Hee Han ◽  
Chul Yung Choi ◽  
Chang-Yeol Yeo ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Nuclear Factor Κb ◽  
Akt Signaling ◽  
Nuclear Factor ◽  
Akt Signaling Pathway ◽  
Phosphatidylinositol 3 Kinase ◽  
Neuronal Protection ◽  
Phosphatidylinositol 3

scholarly journals Nuclear Factor-κB Activating Protein Plays an Oncogenic Role in Neuroblastoma Tumorigenesis and Recurrence Through the Phosphatidylinositol 3-Kinase/Protein Kinase B Signaling Pathway

2021 ◽  
Vol 8 ◽  
Author(s):  
Jun Liu ◽  
Mingyu Zhang ◽  
Ying Kan ◽  
Wei Wang ◽  
Jie Liu ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Protein Kinase B ◽  
Nuclear Factor Κb ◽  
Akt Signaling ◽  
Nuclear Factor ◽  
Akt Signaling Pathway ◽  
Phosphatidylinositol 3 Kinase ◽  
Recurrence Group ◽  
Chromosome 11Q Deletion ◽  
11Q Deletion

Nuclear factor-κB activating protein (NKAP) is a conserved nuclear protein that acts as an oncogene in various cancers and is associated with a poor prognosis. This study aimed to investigate the role of NKAP in neuroblastoma (NB) progression and recurrence. We compared NKAP gene expression between 89 recurrence and 134 non-recurrence patients with NB by utilizing the ArrayExpress database. The relationship between NKAP expression and clinicopathological features was evaluated by correlation analysis. We knocked down NKAP expression in NB1 and SK-N-SH cells by small interfering RNA transfection to verify its role in tumor proliferation, apoptosis, and the phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) signaling pathway. NKAP gene expression in NB tissues was significantly overexpressed in the recurrence group compared with the non-recurrence group, and NKAP was enriched in the PI3K/AKT pathway. Correlation analysis revealed NKAP expression was correlated with chromosome 11q deletion in patients with NB. Knockdown of NKAP expression significantly inhibited the proliferation and promoted the apoptosis of NB1 and SK-N-SH cells. Moreover, we found that small interfering NKAP significantly reduced p-PI3K and p-AKT expression. NKAP knockdown played an oncogenic role in NB by inhibiting PI3K/AKT signaling pathway activations both in vitro and in vivo. Our research revealed that NKAP mediates NB cells by inhibited proliferation and promoted apoptosis through activating the PI3K/AKT signaling pathways, and the expression of NKAP may act as a novel biomarker for predicting recurrence and chromosome 11q deletion in patients with NB.

scholarly journals Statins Prevent Oxidized LDL-Induced Injury of Glomerular Podocytes by Activating the Phosphatidylinositol 3-Kinase/AKT-Signaling Pathway

2005 ◽  
Vol 16 (7) ◽  
pp. 1936-1947 ◽  
Author(s):  
Benedetta Bussolati ◽  
Maria Chiara Deregibus ◽  
Valentina Fonsato ◽  
Sophie Doublier ◽  
Tiziana Spatola ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Oxidized Ldl ◽  
Akt Signaling ◽  
Akt Signaling Pathway ◽  
Phosphatidylinositol 3 Kinase ◽  
Phosphatidylinositol 3

scholarly journals Phosphatidylinositol 3-Kinase/Akt Signaling Pathway Activates the WNK-OSR1/SPAK-NCC Phosphorylation Cascade in Hyperinsulinemic db/db Mice

Hypertension ◽  
2012 ◽  
Vol 60 (4) ◽  
pp. 981-990 ◽  
Author(s):  
Hidenori Nishida ◽  
Eisei Sohara ◽  
Naohiro Nomura ◽  
Motoko Chiga ◽  
Dario R. Alessi ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Akt Signaling ◽  
Akt Signaling Pathway ◽  
Phosphatidylinositol 3 Kinase ◽  
Phosphorylation Cascade ◽  
Phosphatidylinositol 3
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