scholarly journals Lead Exposure Disrupts Global DNA Methylation in Human Embryonic Stem Cells and Alters Their Neuronal Differentiation

2014 ◽  
Vol 139 (1) ◽  
pp. 142-161 ◽  
Author(s):  
Marie-Claude Senut ◽  
Arko Sen ◽  
Pablo Cingolani ◽  
Asra Shaik ◽  
Susan J. Land ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Neuronal Differentiation ◽  
Human Embryonic Stem Cells ◽  
Lead Exposure ◽  
Embryonic Stem ◽  
Global Dna Methylation

Heterogeneity and Randomness of DNA Methylation Patterns in Human Embryonic Stem Cells

2012 ◽  
Vol 31 (6) ◽  
pp. 893-907 ◽  
Author(s):  
Albert G. Tsai ◽  
Debbie M. Chen ◽  
Mayin Lin ◽  
John C. F. Hsieh ◽  
Cindy Y. Okitsu ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Methylation Patterns

The effects of electrospun TSF nanofiber diameter and alignment on neuronal differentiation of human embryonic stem cells

2011 ◽  
Vol 100A (3) ◽  
pp. 632-645 ◽  
Author(s):  
Junxia Wang ◽  
Rong Ye ◽  
Youhua Wei ◽  
Huihui Wang ◽  
Xiaojing Xu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Neuronal Differentiation ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Nanofiber Diameter

scholarly journals Distinct DNA methylation patterns characterize differentiated human embryonic stem cells and developing human fetal liver

2009 ◽  
Vol 19 (6) ◽  
pp. 1044-1056 ◽  
Author(s):  
A. L. Brunner ◽  
D. S. Johnson ◽  
S. W. Kim ◽  
A. Valouev ◽  
T. E. Reddy ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Fetal Liver ◽  
Embryonic Stem ◽  
Human Fetal Liver ◽  
Methylation Patterns

scholarly journals Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants

2022 ◽  
Vol 13 (1) ◽  
Author(s):  
Bret Sanders ◽  
Daniel D’Andrea ◽  
Mark O. Collins ◽  
Elliott Rees ◽  
Tom G. J. Steward ◽  
...  
Keyword(s):  
Gene Expression ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Neuronal Differentiation ◽  
Human Embryonic Stem Cells ◽  
De Novo ◽  
Embryonic Stem ◽  
Neuropsychiatric Disorders ◽  
Loss Of Function ◽  
Excitatory Neurons

AbstractCoordinated programs of gene expression drive brain development. It is unclear which transcriptional programs, in which cell-types, are affected in neuropsychiatric disorders such as schizophrenia. Here we integrate human genetics with transcriptomic data from differentiation of human embryonic stem cells into cortical excitatory neurons. We identify transcriptional programs expressed during early neurogenesis in vitro and in human foetal cortex that are down-regulated in DLG2−/− lines. Down-regulation impacted neuronal differentiation and maturation, impairing migration, morphology and action potential generation. Genetic variation in these programs is associated with neuropsychiatric disorders and cognitive function, with associated variants predominantly concentrated in loss-of-function intolerant genes. Neurogenic programs also overlap schizophrenia GWAS enrichment previously identified in mature excitatory neurons, suggesting that pathways active during prenatal cortical development may also be associated with mature neuronal dysfunction. Our data from human embryonic stem cells, when combined with analysis of available foetal cortical gene expression data, de novo rare variants and GWAS statistics for neuropsychiatric disorders and cognition, reveal a convergence on transcriptional programs regulating excitatory cortical neurogenesis.

Folate antagonist, methotrexate induces neuronal differentiation of human embryonic stem cells transplanted into nude mouse retina

2010 ◽  
Vol 477 (3) ◽  
pp. 138-143 ◽  
Author(s):  
Akira Hara ◽  
Ayako Taguchi ◽  
Hitomi Aoki ◽  
Yuichiro Hatano ◽  
Masayuki Niwa ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Neuronal Differentiation ◽  
Nude Mouse ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Mouse Retina

scholarly journals Genome-wide dynamic changes of DNA methylation of repetitive elements in human embryonic stem cells and fetal fibroblasts

Genomics ◽  
2012 ◽  
Vol 99 (1) ◽  
pp. 10-17 ◽  
Author(s):  
Jianzhong Su ◽  
Xiujuan Shao ◽  
Hongbo Liu ◽  
Shengqiang Liu ◽  
Qiong Wu ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Repetitive Elements ◽  
Dynamic Changes ◽  
Genome Wide ◽  
Fetal Fibroblasts

Effects of methylmercury exposure on neuronal differentiation of mouse and human embryonic stem cells

2012 ◽  
Vol 212 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Xiaoming He ◽  
Satoshi Imanishi ◽  
Hideko Sone ◽  
Reiko Nagano ◽  
Xian-Yang Qin ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Neuronal Differentiation ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Methylmercury Exposure

P3-388: Differential processing of amyloid-β precursor protein directs the proliferation and neuronal differentiation of human embryonic stem cells

2008 ◽  
Vol 4 ◽  
pp. T635-T635
Author(s):  
Prashob Porayette ◽  
Miguel J. Gallego ◽  
Maria M. Kaltcheva ◽  
Richard L. Bowen ◽  
Sivan Vadakkadath Meethal ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Neuronal Differentiation ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Amyloid Β ◽  
Precursor Protein ◽  
Differential Processing

Induced neuronal differentiation of human embryonic stem cells

2001 ◽  
Vol 913 (2) ◽  
pp. 201-205 ◽  
Author(s):  
Maya Schuldiner ◽  
Rachel Eiges ◽  
Amir Eden ◽  
Ofra Yanuka ◽  
Joseph Itskovitz-Eldor ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Neuronal Differentiation ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem
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