scholarly journals Analgesic Effect of Oral Glucose in Preterm Infants During Venipuncture--A Double-blind, Randomized, Controlled Trial

2002 ◽  
Vol 48 (3) ◽  
pp. 138-141 ◽  
Author(s):  
L. S. Deshmukh
Keyword(s):  
Randomized Controlled Trial ◽  
Preterm Infants ◽  
Analgesic Effect ◽  
Controlled Trial ◽  
Oral Glucose ◽  
Double Blind ◽  
Randomized Controlled

scholarly journals Baseline Characteristics of Participants in a Randomized Controlled Trial of Metformin for Frailty Prevention

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 130-131
Author(s):  
Tiffany Cortes ◽  
Nicolas Musi ◽  
Chen-pin Wang ◽  
Joel Michalek ◽  
Sara Espinoza
Keyword(s):  
Randomized Controlled Trial ◽  
Glucose Tolerance ◽  
Physical Performance ◽  
Controlled Trial ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Double Blind ◽  
Randomized Controlled ◽  
Insulin Clamp ◽  
And Function

Abstract We are conducting a double-blind, randomized controlled trial of metformin for frailty prevention. Participants are adults aged 65+ years with pre-diabetes assessed by 2-hour oral glucose tolerance test (OGTT). Those who are frail (Fried criteria) are excluded. Participants are randomized to metformin (maximum dose of 2,000 mg/day) vs. placebo and followed for 2 years. The primary outcome is frailty (category and score); secondary outcomes are physical performance and function (short physical performance battery, 6-minute walk, lower extremity strength), systemic and skeletal muscle tissue inflammation, muscle insulin signaling, insulin sensitivity (insulin clamp), glucose tolerance (OGTT), and body composition (dual-energy x-ray absorptiometry). Safety assessments occur every 3 months; frailty, systemic inflammation, and OGTT are assessed at baseline and every 6 months, and insulin clamp with muscle biopsies are assessed at baseline and every 12 months. To date, 85 subjects have been randomized; 120 completers are planned. Mean age is 72.8 ± 5.7 years, 55.3% are male, and 43.5% were Hispanic. Mean BMI is 30.2±5.8 kg/m2, waist circumference is 104.4 ±15.5 cm, fasting glucose is 102.3 ± 10.0 mg/dL, Hemoglobin A1c is 5.8 ±0.3, and glucose at 2 hours during OGTT is 167.3 ± 17.8 mg/dL. Metformin is being examined in this study as a potential therapeutic agent to prevent frailty in older adults with pre-diabetes. Findings from this trial may have future implications for the screening and potential treatment of pre-diabetes in older patients with metformin for the prevention of frailty.

Oral Glucose and Listening to Lullaby to Decrease Pain in Preterm Infants Supported with NCPAP: A Randomized Controlled Trial

2019 ◽  
Vol 20 (1) ◽  
pp. 54-61 ◽  
Author(s):  
Kadir Şerafettin Tekgündüz ◽  
Sevinç Polat ◽  
Ayşe Gürol ◽  
Serap Ejder Apay
Keyword(s):  
Randomized Controlled Trial ◽  
Preterm Infants ◽  
Controlled Trial ◽  
Oral Glucose ◽  
Randomized Controlled

scholarly journals Myo-Inositol, Probiotics, and Micronutrient Supplementation From Preconception for Glycemia in Pregnancy: NiPPeR International Multicenter Double-Blind Randomized Controlled Trial

2021 ◽  
Author(s):  
Keith M Godfrey ◽  
Sheila J Barton ◽  
Sarah El-Heis ◽  
Timothy Kenealy ◽  
Heidi Nield ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Preterm Birth ◽  
Primary Outcome ◽  
Controlled Trial ◽  
Preterm Births ◽  
Oral Glucose ◽  
Double Blind ◽  
Adjusted Risk ◽  
Randomized Controlled ◽  
In Pregnancy

<b>Objective:</b> Better preconception metabolic and nutritional health are hypothesized to promote gestational normoglycemia and reduce preterm birth, but evidence supporting improved outcomes with nutritional supplementation starting preconception is limited. <p><b>Research Design and Methods:</b> Double-blind randomized controlled trial recruited from the community 1729 UK, Singapore and New Zealand women aged 18-38 years planning conception. We investigated if a nutritional formulation containing myo-inositol, probiotics and multiple micronutrients (intervention), compared with a standard micronutrient supplement (control), taken preconception and throughout pregnancy, could improve pregnancy outcomes. The primary outcome was combined fasting, 1-hour and 2-hour post-load glycemia (28 weeks’ gestation oral glucose tolerance test).</p> <p><b>Results</b>: Between 2015-2017, participants were randomized to control (n=859) or intervention (n=870); 585 conceived within 1-year and completed the primary outcome (295 intervention, 290 control). In an intention-to-treat analysis adjusting for site, ethnicity and preconception glycemia with pre-specified p<0.017 for multiplicity, there were no differences in gestational fasting, 1-hour and 2-hour glycemia between groups (β [95%CI] log<sub>e</sub> mmol/L intervention versus control: -0·004 [-0·018, 0·011], 0·025 [-0·014, 0·064], 0·040 [0·004, 0·077], respectively). Between the intervention and control groups there were no significant differences in gestational diabetes (24·8% versus 22·6%, adjusted risk ratio aRR=1·22 [0·92, 1·62]), birthweight (adjusted β=0·05kg [-0·03, 0·13]), or gestational age at birth (mean 39.3 versus 39.2 weeks, adjusted β=0·20 [-0·06, 0·46]), but there were fewer preterm births (5·8% versus 9·2%, aRR=0·43 [0·22, 0·82]) adjusting for pre-specified covariates.</p> <p><b>Conclusions: </b>Supplementation with myo-inositol, probiotics and micronutrients preconception and in pregnancy did not lower gestational glycemia, but did reduce preterm birth. </p> <br>

scholarly journals Endogenous analgesic effect of pregabalin: A double-blind and randomized controlled trial

2017 ◽  
Vol 21 (6) ◽  
pp. 997-1006 ◽  
Author(s):  
S. Sugimine ◽  
S. Saito ◽  
T. Araki ◽  
K. Yamamoto ◽  
H. Obata
Keyword(s):  
Randomized Controlled Trial ◽  
Analgesic Effect ◽  
Controlled Trial ◽  
Double Blind ◽  
Randomized Controlled

scholarly journals Comparison of the analgesic effect of ibuprofen with mesalamine after discectomy surgery in patients with lumbar disc herniation: A double-blind randomized controlled trial

2009 ◽  
Vol 57 (3) ◽  
pp. 305 ◽  
Author(s):  
MohammadBorghei Razavi ◽  
HamidBorghei Razavi ◽  
RezaMostafavi Tabatabayi ◽  
YaserTolouei Tabar ◽  
SeyyedTaha Yahyavi ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Lumbar Disc Herniation ◽  
Disc Herniation ◽  
Analgesic Effect ◽  
Controlled Trial ◽  
Lumbar Disc ◽  
Double Blind ◽  
Randomized Controlled

scholarly journals Myo-Inositol, Probiotics, and Micronutrient Supplementation From Preconception for Glycemia in Pregnancy: NiPPeR International Multicenter Double-Blind Randomized Controlled Trial

2021 ◽  
Author(s):  
Keith M Godfrey ◽  
Sheila J Barton ◽  
Sarah El-Heis ◽  
Timothy Kenealy ◽  
Heidi Nield ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Preterm Birth ◽  
Primary Outcome ◽  
Controlled Trial ◽  
Preterm Births ◽  
Oral Glucose ◽  
Double Blind ◽  
Adjusted Risk ◽  
Randomized Controlled ◽  
In Pregnancy

<b>Objective:</b> Better preconception metabolic and nutritional health are hypothesized to promote gestational normoglycemia and reduce preterm birth, but evidence supporting improved outcomes with nutritional supplementation starting preconception is limited. <p><b>Research Design and Methods:</b> Double-blind randomized controlled trial recruited from the community 1729 UK, Singapore and New Zealand women aged 18-38 years planning conception. We investigated if a nutritional formulation containing myo-inositol, probiotics and multiple micronutrients (intervention), compared with a standard micronutrient supplement (control), taken preconception and throughout pregnancy, could improve pregnancy outcomes. The primary outcome was combined fasting, 1-hour and 2-hour post-load glycemia (28 weeks’ gestation oral glucose tolerance test).</p> <p><b>Results</b>: Between 2015-2017, participants were randomized to control (n=859) or intervention (n=870); 585 conceived within 1-year and completed the primary outcome (295 intervention, 290 control). In an intention-to-treat analysis adjusting for site, ethnicity and preconception glycemia with pre-specified p<0.017 for multiplicity, there were no differences in gestational fasting, 1-hour and 2-hour glycemia between groups (β [95%CI] log<sub>e</sub> mmol/L intervention versus control: -0·004 [-0·018, 0·011], 0·025 [-0·014, 0·064], 0·040 [0·004, 0·077], respectively). Between the intervention and control groups there were no significant differences in gestational diabetes (24·8% versus 22·6%, adjusted risk ratio aRR=1·22 [0·92, 1·62]), birthweight (adjusted β=0·05kg [-0·03, 0·13]), or gestational age at birth (mean 39.3 versus 39.2 weeks, adjusted β=0·20 [-0·06, 0·46]), but there were fewer preterm births (5·8% versus 9·2%, aRR=0·43 [0·22, 0·82]) adjusting for pre-specified covariates.</p> <p><b>Conclusions: </b>Supplementation with myo-inositol, probiotics and micronutrients preconception and in pregnancy did not lower gestational glycemia, but did reduce preterm birth. </p> <br>

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