scholarly journals Nitric Oxide Inhibition of Tobacco Catalase and Ascorbate Peroxidase

2000 ◽  
Vol 13 (12) ◽  
pp. 1380-1384 ◽  
Author(s):  
Daniel Clark ◽  
Jörg Durner ◽  
Duroy A. Navarre ◽  
Daniel F. Klessig
Keyword(s):  
Nitric Oxide ◽  
Enzymatic Activity ◽  
Ascorbate Peroxidase ◽  
Plant Cells ◽  
Defense Responses ◽  
No Donor ◽  
No Donors ◽  
Nitric Oxide Inhibition ◽  
Scavenging Enzymes ◽  
Oxide Inhibition

We used a variety of nitric oxide (NO) donors to demonstrate that NO inhibits the activities of tobacco catalase and ascorbate peroxidase (APX). This inhibition appears to be reversible because removal of the NO donor led to a significant recovery of enzymatic activity. In contrast, APX and catalase were irreversibly inhibited by peroxynitrite. The ability of NO and peroxynitrite to inhibit the two major H2O2-scavenging enzymes in plant cells suggests that NO may participate in redox signaling during the activation of defense responses following pathogen attack.

Lipid hydroperoxide and cGMP are not involved in nitric oxide inhibition of steroidogenesis in bovine granulosa cells

2000 ◽  
Vol 12 (6) ◽  
pp. 289 ◽  
Author(s):  
G. Basini ◽  
F. Grasselli ◽  
N. Ponderato ◽  
S. Bussolati ◽  
C. Tamanini
Keyword(s):  
Nitric Oxide ◽  
Signal Transduction ◽  
Granulosa Cells ◽  
Soluble Guanylate Cyclase ◽  
Lipid Hydroperoxide ◽  
Lipid Hydroperoxides ◽  
No Donor ◽  
Nitric Oxide Inhibition ◽  
Cgmp Signalling ◽  
Oxide Inhibition

The present study was performed to explore two of the possible signalling mechanisms through which nitric oxide (NO) inhibits steroidogenesis in bovine granulosa cells. Because cGMP is generally known to play a pivotal role in NO signal transduction, the first aim of the present study was to verify the presence of a functional NO–cGMP signalling pathway. Because non-cGMP-dependent pathways could be involved in the inhibition of steroidogenesis by NO, we examined the formation of lipid hydroperoxides (LPOs), possibly induced by NO. Using bovine granulosa cells collected from small (< 5 mm) and large (> 8 mm) follicles, the effectiveness of the NO donor s-nitroso-N-acetylpenicillamine (SNAP; 10–3, 10–4 and 10–5 M) in stimulating cGMP production and the formation of LPOs was examined. The second aim of the present study was to determine whether the effects of NO on steroidogenesis could be mimicked by treatment of cells with a cGMP analogue (8-bromo-cGMP (8-Br-cGMP); 10–3, 10–4 and 10–5 M) and whether these effects could be reversed by [1H]-[1,2,3]oxadiaziolo[4,3a]quinoxaline-1-one (ODQ; 10–5 and 10–4 M) an inhibitor of NO-sensitive soluble guanylate cyclase. The highest dose of SNAP used induced a significant (P<0.01) increase in cGMP levels, while other concentrations tested were ineffective. Neither concentration of ODQ used significantly inhibited basal cGMP output, while both concentrations counteracted the stimulatory effect of SNAP. Treatment of cells with 8-Br-cGMP and ODQ was ineffective in modifying steroidogenesis. Treatment with SNAP, at the three concentrations tested, had no significant effect on the level of LPOs. The present results suggest that NO inhibits steroidogenesis in bovine granulosa cells without involving cGMP and LPOs.

Nifedipine Prevents Renal Injury in Rats With Chronic Nitric Oxide Inhibition

Hypertension ◽  
1995 ◽  
Vol 26 (1) ◽  
pp. 150-155 ◽  
Author(s):  
Miriam Oliveira Ribeiro ◽  
Edson Antunes ◽  
Marcelo Nicolas Muscará ◽  
Gilberto De Nucci ◽  
Roberto Zatz
Keyword(s):  
Nitric Oxide ◽  
Renal Injury ◽  
Nitric Oxide Inhibition ◽  
Oxide Inhibition

Mechanism of nitric oxide inhibition in human jejunal smooth muscle

2000 ◽  
Vol 191 (4) ◽  
pp. S25-S26
Author(s):  
Nicholas J Zyromski ◽  
Judith A Duenes ◽  
Michael L Kendrick ◽  
Gianrico Farrugia ◽  
Michael G Sarr
Keyword(s):  
Nitric Oxide ◽  
Smooth Muscle ◽  
Nitric Oxide Inhibition ◽  
Oxide Inhibition

scholarly journals Regulation of renin release is impaired after nitric oxide inhibition

1996 ◽  
Vol 49 (3) ◽  
pp. 626-633 ◽  
Author(s):  
Christos Chatziantoniou ◽  
Marie-Dominique Pauti ◽  
Florence Pinet ◽  
Dominique Promeneur ◽  
Jean-Claude Dussaule ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Renin Release ◽  
Nitric Oxide Inhibition ◽  
Oxide Inhibition

P012 ASSESSMENT OF INTESTINAL PERMEABILITY AND INTERFERON-GAMA LEVELS AFTER NITRIC OXIDE INHIBITION IN ANIMALS SUPPLEMENTED WITH GLUTAMINE

2009 ◽  
Vol 4 (2) ◽  
pp. 30
Author(s):  
M.T.D. Correia ◽  
R.G.C. Santos ◽  
M.L. Viana ◽  
S.V. Generoso ◽  
J. Nogueira-Machado ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Intestinal Permeability ◽  
Nitric Oxide Inhibition ◽  
Oxide Inhibition

Nitric Oxide Inhibition Increases Aortic Wall Matrix Metalloproteinase-9 Expression

2002 ◽  
Vol 104 (1) ◽  
pp. 15-21 ◽  
Author(s):  
Matthew J. Eagleton ◽  
David A. Peterson ◽  
Vita V. Sullivan ◽  
Karen J. Roelofs ◽  
John A. Ford ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Matrix Metalloproteinase ◽  
Aortic Wall ◽  
Matrix Metalloproteinase 9 ◽  
Nitric Oxide Inhibition ◽  
Metalloproteinase 9 ◽  
Oxide Inhibition
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