scholarly journals Inflammatory Response In The Small Intestine Induced By Hind Limb Ischemia/Reperfusion (I/R): Role of iNOS

2006 ◽  
Vol 20 (5) ◽  
Author(s):  
Kazuhiro Katada ◽  
Aurelia Bihari ◽  
Big Wei Sun ◽  
Kenneth A. Harris ◽  
Richard F. Potter ◽  
...  
Keyword(s):  
Small Intestine ◽  
Inflammatory Response ◽  
Hind Limb ◽  
Ischemia Reperfusion ◽  
Limb Ischemia ◽  
Hind Limb Ischemia

scholarly journals Role of Scutellarin in Ameliorating Lung Injury in a Rat Model of Bilateral Hind Limb Ischemia–Reperfusion

2019 ◽  
Vol 302 (11) ◽  
pp. 2070-2081 ◽  
Author(s):  
Marwa A. A. Ibrahim ◽  
Walaa M. Elwan ◽  
Hanan A. Elgendy
Keyword(s):  
Lung Injury ◽  
Rat Model ◽  
Hind Limb ◽  
Ischemia Reperfusion ◽  
Limb Ischemia ◽  
Hind Limb Ischemia

scholarly journals The Role of Indoleamine 2,3 Dioxygenase in Beneficial Effects of Stem Cells in Hind Limb Ischemia Reperfusion Injury

PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e95720 ◽  
Author(s):  
Mohamad Masoumy ◽  
Jack Yu ◽  
Jun Yao Liu ◽  
Nathan Yanasak ◽  
Christopher Middleton ◽  
...  
Keyword(s):  
Stem Cells ◽  
Reperfusion Injury ◽  
Hind Limb ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Limb Ischemia ◽  
Hind Limb Ischemia ◽  
Beneficial Effects ◽  
Indoleamine 2,3 Dioxygenase

scholarly journals The intestinal tract as the major source of interleukin 6 production during abdominal aortic clamping and hind limb ischaemia-reperfusion injury

2007 ◽  
Vol 22 (suppl 1) ◽  
pp. 34-39 ◽  
Author(s):  
Márcio Benedito Palma Pimenta ◽  
José Eduardo de Aguilar-Nascimento ◽  
Dely Cristina Martins ◽  
Daniele Ribastski da Silva ◽  
Kátia Leston Bacelo ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Reperfusion Injury ◽  
Interleukin 6 ◽  
Hind Limb ◽  
Intestinal Tract ◽  
Ischemia Reperfusion ◽  
Limb Ischemia ◽  
Hind Limb Ischemia ◽  
Aortic Clamping ◽  
Hind Limbs

PURPOSE: The aim of this study was to investigate whether the hind limbs or intestinal tract is the most important initiator of the inflammatory response secondary aortic clamping and hind limb ischemia/reperfusion injury. METHODS: Blood samples of Wistar rats obtained from posterior cava vein, portal vein, and heart cavity during either laparotomy (control group, n=8) or laparotomy + 2 h of aortic clamping and bilateral hind limb ischemia (ischemia group, n=8), or 2 h after ischemia and 2 h of reperfusion (ischemia-reperfusion group, n=8) were assayed for interleukin 6 (IL-6) and C-reactive protein (CRP). RESULTS: Serum IL-6 at the heart (223.6±197.9 [10-832] pg/mL) was higher (p<0.001) than at both portal (133.08±108.52 [4-372] pg/mL) and posterior cava veins (127.58±109.15 [8-388] pg/mL). CRP was not significant different among groups. CONCLUSION: The splanchnic region is also a source of inflammatory response secondary to ischemia and reperfusion of the hind limbs.

scholarly journals Role of iNOS‐derived nitric oxide (NO) on hind limb ischemia/reperfusion (I/R)‐induced remote injury to the gut

2007 ◽  
Vol 21 (6) ◽  
Author(s):  
Kazuhiro Katada ◽  
Aurelia Bihari ◽  
Kenneth A Harris ◽  
Tom L Forbes ◽  
Richard F Potter ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Hind Limb ◽  
Ischemia Reperfusion ◽  
Limb Ischemia ◽  
Hind Limb Ischemia

scholarly journals WITHDRAWN: Melatonin attenuates lung injury in a hind limb ischemia–reperfusion rat model

2014 ◽  
Author(s):  
Hamed Takhtfooladi ◽  
Mohammad Takhtfooladi ◽  
Fariborz Moayer ◽  
Sayed Mobarakeh
Keyword(s):  
Lung Injury ◽  
Rat Model ◽  
Hind Limb ◽  
Ischemia Reperfusion ◽  
Limb Ischemia ◽  
Hind Limb Ischemia

Abstract 17597: Endogenous Del-1 is a Negative Regulator of Ischemia-induced Angiogenesis by Interacting With the Leukocytic LFA-1 Integrin

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Sebastian Cremer ◽  
Anne Klotzsche-von Ameln ◽  
Alessia Orlandi ◽  
Irina Korovina ◽  
Bettina Gercken ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Hind Limb ◽  
Hematopoietic Cells ◽  
Limb Ischemia ◽  
Inflammatory Cells ◽  
Capillary Density ◽  
Negative Regulator ◽  
Hind Limb Ischemia ◽  
Autonomous Pathway

Developmental endothelial locus-1 (Del-1) is an endothelial cell-derived secreted protein circulating in blood and associated with the cell surface and the extracellular matrix. As we previously demonstrated, Del-1 restricts leukocyte recruitment by inhibiting the β2-integrin, LFA-1. Leukocytes and progenitor cells (PC) may contribute to angiogenesis. The role of endogenous Del-1 in angiogenesis is elusive. We found, that physiological angiogenesis of the developing retina was not affected in the Del-1-/- mice compared to the wildtype (WT) mice. Surprisingly, Del-1-/- mice displayed a significantly increased angiogenic response compared to WT mice after induction of hind limb ischemia (144 ± 6 % increase of capillary density) and retinal ischemia (retinopathy of prematurity model) suggesting that endogenous Del-1 is an inhibitor of ischemia-induced neovascularization. Silencing of Del-1 with siRNA did not affect the angiogenic sprouting of endothelial cell (EC) spheroids, indicating that Del-1 blocks angiogenesis in a non-endothelial cell autonomous pathway. Soluble Del-1 blocked the adhesion of inflammatory cells on EC monolayers. In line with these results, ischemic muscles and ischemic retinae from Del-1-/- mice displayed an enhanced infiltration with inflammatory cells compared to the WT mice. Since Del-1 blocks inflammatory cell homing by inhibiting the leukocytic LFA-1-integrin, we addressed the role of the Del-1/LFA-1-integrin interaction on the inhibitory function of endogenous Del-1 on angiogenesis. Indeed, Del-1/LFA-1-double deficiency reversed the pro-angiogenic phenotype of the Del-1-/- mice to the level of WT mice in the model of hind limb ischemia. Thus, the inhibitory role of Del-1 on neovascularization is mediated by the interaction of Del-1 with the LFA-1-integrin. Moreover, Del-1-deficiency led to an increased homing of intravenously injected murine fluorescence-labeled WT Lin- BM PC in ischemic muscles in comparison to WT mice after the induction of hind limb ischemia. Taken together, Del-1 acts as a negative regulator of ischemia-induced angiogenesis by interacting with the LFA-1-integrin expressed in hematopoietic cells, thereby inhibiting the homing of hematopoietic cells to ischemic tissues.

scholarly journals Apolipoprotein E–/– mice have delayed skeletal muscle healing after hind limb ischemia–reperfusion

2008 ◽  
Vol 48 (3) ◽  
pp. 701-708 ◽  
Author(s):  
Jeanwan Kang ◽  
Hassan Albadawi ◽  
Virendra I. Patel ◽  
Thomas A. Abbruzzese ◽  
Jin-Hyung Yoo ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Apolipoprotein E ◽  
Hind Limb ◽  
Ischemia Reperfusion ◽  
Limb Ischemia ◽  
Hind Limb Ischemia

scholarly journals Hydrogen Sulfide Reduces Neutrophil Recruitment in Hind-Limb Ischemia-Reperfusion Injury in an L-Selectin and ADAM-17–Dependent Manner

2013 ◽  
Vol 131 (3) ◽  
pp. 487-497 ◽  
Author(s):  
Carissa J. Ball ◽  
Alyssa J. Reiffel ◽  
Sathvika Chintalapani ◽  
Minsoo Kim ◽  
Jason A. Spector ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Reperfusion Injury ◽  
Hind Limb ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Limb Ischemia ◽  
Neutrophil Recruitment ◽  
Dependent Manner ◽  
Hind Limb Ischemia

scholarly journals Proangiogenic role of PPARá in the mouse hind limb ischemia model

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Yasmeen Rizvi ◽  
Adebayo Oyekan
Keyword(s):  
Hind Limb ◽  
Limb Ischemia ◽  
Hind Limb Ischemia
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