Catfish (Arius bilineatus, Val.) skin protein preparation ameliorates neurobehavioral and axonal and neuronal histopathological alterations in a sciatic nerve crush injury rat model: a novel approach

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Waleed M Renno ◽  
Mohammad M Afzal ◽  
Bincy M Paul ◽  
Divya M Nair ◽  
Jijin M Kumar ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Rat Model ◽  
Crush Injury ◽  
Sciatic Nerve Crush ◽  
Nerve Crush ◽  
Protein Preparation ◽  
Histopathological Alterations ◽  
Novel Approach ◽  
Skin Protein ◽  
Nerve Crush Injury

scholarly journals Canine Adipose-Derived Mesenchymal Stromal Cells Enhance Neuroregeneration in a Rat Model of Sciatic Nerve Crush Injury

2018 ◽  
Vol 28 (1) ◽  
pp. 47-54 ◽  
Author(s):  
Diego Noé Rodríguez Sánchez ◽  
Luiz Antonio de Lima Resende ◽  
Giovana Boff Araujo Pinto ◽  
Ana Lívia de Carvalho Bovolato ◽  
Fábio Sossai Possebon ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Mesenchymal Stromal Cells ◽  
Rat Model ◽  
Stromal Cells ◽  
Multipotent Mesenchymal Stromal Cells ◽  
Crush Injury ◽  
Sciatic Nerve Crush ◽  
Muscle Weight ◽  
Nerve Crush ◽  
Nerve Crush Injury

Crush injuries in peripheral nerves are frequent and induce long-term disability with motor and sensory deficits. Due to axonal and myelin sheath disruptions, strategies for optimized axonal regeneration are needed. Multipotent mesenchymal stromal cells (MSC) are promising because of their anti-inflammatory properties and secretion of neurotrophins. The present study investigated the effect of canine adipose tissue MSC (Ad-MSC) transplantation in an experimental sciatic nerve crush injury. Wistar rats were divided into three groups: sham ( n = 8); Crush+PBS ( n = 8); Crush+MSC ( n = 8). Measurements of sciatic nerve functional index (SFI), muscle mass, and electromyography (EMG) were performed. Canine Ad-MSC showed mesodermal characteristics (CD34-, CD45-, CD44+, CD90+ and CD105+) and multipotentiality due to chondrogenic, adipogenic, and osteogenic differentiation. SFI during weeks 3 and 4 was significantly higher in the Crush+MSC group ( p < 0.001). During week 4, the EMG latency in the Crush+MSC groups had better near normality ( p < 0.05). The EMG amplitude showed results close to normality during week 4 in the Crush+MSC group ( p < 0.04). There were no statistical differences in muscle weight between the groups ( p > 0.05), but there was a tendency toward weight gain in the Crush+MSC groups. Better motor functional recovery after crush and perineural canine Ad-MSC transplantation was observed during week 2. This was maintained till week 4. In conclusion, the canine Ad-MSC transplantation showed early pro-regenerative effects between 2–4 weeks in the rat model of sciatic nerve crush injury.

scholarly journals Expression of VEGF and neural repair after alprostadil treatment in a rat model of sciatic nerve crush injury

2009 ◽  
Vol 57 (4) ◽  
pp. 387 ◽  
Author(s):  
Xinsheng Ding ◽  
Jinrong Tang ◽  
Ye Hua ◽  
Jianhua Su ◽  
Ping Zhang ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Rat Model ◽  
Crush Injury ◽  
Sciatic Nerve Crush ◽  
Nerve Crush ◽  
Neural Repair ◽  
Nerve Crush Injury

scholarly journals Effect of Zofenopril on regeneration of sciatic nerve crush injury in a rat model

2014 ◽  
Vol 04 (01) ◽  
pp. e29-e35 ◽  
Author(s):  
Ali Kalender ◽  
Ali Dogan ◽  
Vedat Bakan ◽  
Huseyin Yildiz ◽  
Mehmet Gokalp ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Rat Model ◽  
Crush Injury ◽  
Sciatic Nerve Crush ◽  
Nerve Crush ◽  
Nerve Crush Injury

Muscle-derived GDNF facilitates motor nerve recovery following sciatic nerve crush injury

2007 ◽  
Vol 205 (3) ◽  
pp. S92
Author(s):  
Terence M. Myckatyn ◽  
Christina Kenney ◽  
Alice Tong ◽  
Jessica Duan ◽  
Daniel Hunter ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Motor Nerve ◽  
Crush Injury ◽  
Sciatic Nerve Crush ◽  
Nerve Crush ◽  
Nerve Recovery ◽  
Nerve Crush Injury
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