scholarly journals Constituents of Artemisia annua Dietary Supplements Induce ROS Elevation, ERK Activation, and Apoptosis in Treatment‐Resistant Triple Negative Human Breast Cancer Cells

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Sophia Lang ◽  
Michael Schmiech ◽  
Susanne Hafner ◽  
Christian Paetz ◽  
Christoph Q Schmidt ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Artemisia Annua ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Treatment Resistant ◽  
Erk Activation

scholarly journals MicroRNA-378-mediated suppression of Runx1 alleviates the aggressive phenotype of triple-negative MDA-MB-231 human breast cancer cells

Tumor Biology ◽  
2016 ◽  
Vol 37 (7) ◽  
pp. 8825-8839 ◽  
Author(s):  
Gillian Browne ◽  
Julie A. Dragon ◽  
Deli Hong ◽  
Terri L. Messier ◽  
Jonathan A. R. Gordon ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Aggressive Phenotype

scholarly journals Bcl-2 inhibition sensitizes triple-negative human breast cancer cells to doxorubicin

Oncotarget ◽  
2018 ◽  
Vol 9 (39) ◽  
pp. 25545-25556 ◽  
Author(s):  
Touko Inao ◽  
Yuichi Iida ◽  
Tamami Moritani ◽  
Tamio Okimoto ◽  
Ryosuke Tanino ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Human Breast Cancer Cells ◽  
Human Breast

scholarly journals Polyphenols Extracted from Artemisia annua L. Exhibit Anti-Cancer Effects on Radio-Resistant MDA-MB-231 Human Breast Cancer Cells by Suppressing Stem Cell Phenotype, β-Catenin, and MMP-9

Molecules ◽  
2020 ◽  
Vol 25 (8) ◽  
pp. 1916
Author(s):  
Young Shin Ko ◽  
Eun Joo Jung ◽  
Se-il Go ◽  
Bae Kwon Jeong ◽  
Gon Sup Kim ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Artemisia Annua ◽  
Janus Kinase ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Artemisia Annua L ◽  
Anti Cancer

Artemisia annua L. has been reported to show anti-cancer activities. Here, we determined whether polyphenols extracted from Artemisia annua L. (pKAL) exhibit anti-cancer effects on radio-resistant MDA-MB-231 human breast cancer cells (RT-R-MDA-MB-231 cells), and further explored their molecular mechanisms. Cell viability assay and colony-forming assay revealed that pKAL inhibited cell proliferation on both parental and RT-R-MDA-MB-231 cells in a dose-dependent manner. The anti-proliferative effects of pKAL on RT-R-MDA-MB-231 cells were superior or similar to those on parental ones. Western blot analysis revealed that expressions of cluster of differentiation 44 (CD44) and Oct 3/4, matrix metalloproteinase-9 (MMP-9) and signal transducer and activator of transcription-3 (STAT-3) phosphorylation were significantly increased in RT-R-MDA-MB-231 cells compared to parental ones, suggesting that these proteins could be associated with RT resistance. pKAL inhibited the expression of CD44 and Oct 3/4 (CSC markers), and β-catenin and MMP-9 as well as STAT-3 phosphorylation of RT-R-MDA-MB-231. Regarding upstream signaling, the JNK or JAK2 inhibitor could inhibit STAT-3 activation in RT-R-MDA-MB-231 cells, but not augmented pKAL-induced anti-cancer effects. These findings suggest that c-Jun N-terminal kinase (JNK) or Janus kinase 2 (JAK2)/STAT3 signaling are not closely related to the anti-cancer effects of pKAL. In conclusion, this study suggests that pKAL exhibit anti-cancer effects on RT-R-MDA-MB-231 cells by suppressing CD44 and Oct 3/4, β-catenin and MMP-9, which appeared to be linked to RT resistance of RT-R-MDA-MB-231 cells.

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