scholarly journals Regeneration of the peripheral motor nerves and myelin sheath following hyperglycemic induction and recovery

2021 ◽  
Vol 35 (S1) ◽  
Author(s):  
Sheridan Sargent
Development ◽  
1993 ◽  
Vol 119 (2) ◽  
pp. 533-543 ◽  
Author(s):  
K. Broadie ◽  
M. Bate

We have examined the role of innervation in directing embryonic myogenesis, using a mutant (prospero), which delays the pioneering of peripheral motor nerves of the Drosophila embryo. In the absence of motor nerves, myoblasts fuse normally to form syncytial myotubes, myotubes form normal attachments to the epidermis, and a larval musculature comparable to the wild-type pattern is generated and maintained. Likewise, the twist-expressing myoblasts that prefigure the adult musculature segregate normally in the absence of motor nerves, migrate to their final embryonic positions and continue to express twist until the end of embryonic development. In the absence of motor nerves, myotubes uncouple at the correct developmental stage to form single cells. Subsequently, uninnervated myotubes develop the mature electrical and contractile properties of larval muscles with a time course indistinguishable from normally innervated myotubes. We conclude that innervation plays no role in the patterning, morphogenesis, maintenance or physiological development of the somatic muscles in the Drosophila embryo.


2016 ◽  
Vol 16 (suppl 1) ◽  
pp. S83-S88 ◽  
Author(s):  
Ana Catarina Matos Ishigami Alvino ◽  
Luísa Rocha Medeiros de Mello ◽  
Jucille do Amaral Meneses Meira de Oliveira

Abstract Introduction: in 2015 an increasing number of congenital microcephaly cases were associated to maternal infection due to Zika virus. Some of these patients presented other alterations and arthrogryposis was the most frequently found. Arthrogryposis is defined as congenital joint contractures involving at least two different areas of the body. Description: arthrogryposis was found in 18 patients with congenital microcephaly due to Zika virus. 67% of the cases were vaginal deliveries. 50% of resuscitation performed in the delivery room was necessary. The mean birth weight was 2.371g, gestational age was 39 weeks and the head circumference was 28.3cm, 15 (83%) of these patients presented severe microcephaly. All the neonates resulted in concomitant hip joints and some also had knees, ankles and wrists affected. Nine neonates (50%) presented an early respiratory distress and four (22%) died due to respiratory failure. Discussion: the neurological result found in patients with Congenital Zika Syndrome seems to be associated to the maternal infection period. During the early stages of embryogenesis, in addition to microcephaly, could be related to the peripheral motor nerves leading to fetal akinesia, joint stiffness and arthrogryposis. These neonates tend to present greater morbimortality with the worst prognosis.


1987 ◽  
Vol 10 (8) ◽  
pp. 698-710 ◽  
Author(s):  
Robert G. Miller

2013 ◽  
Vol 36 (6) ◽  
pp. 1624-1628 ◽  
Author(s):  
Georgia Tsoumakidou ◽  
Julien Garnon ◽  
Nitin Ramamurthy ◽  
Xavier Buy ◽  
Afshin Gangi

The work of Fayrer(1), and afterwards of Brunton and Fayrer(2), established the fact that in cobra poisoning the failure of the respiration is the cause of death, the circulation surviving for some time after the breathing ceases, and the heart continuing to beat for hours if the aëration of the blood is maintained by artificial respiration. They satisfied themselves that a curara-like paralysis of the motor nerve ends occurs in certain conditions, but they remained in doubt whether the failure of the respiration is entirely due to this, and were inclined to believe that it is due in part to paralysis of the respiratory centre; the phrenic nerve proved insensible to the strongest stimuli in some experiments, while the sciatic remained irritable, and there was a want of co-ordination of the diaphragmatic and thoracic muscles in others, which appeared to arise from paralysis of the phrenic nerve. In 1883 A. J. Wall (3) concluded that, while the peripheral motor nerves are weakened, this is accompanied by a similar weakening of the central nervous system, and especially of the spinal cord.


Sign in / Sign up

Export Citation Format

Share Document