scholarly journals GPR56 binds tissue transglutaminase and inhibits melanoma tumor growth and metastasis

2007 ◽  
Vol 21 (5) ◽  
Author(s):  
Lei Xu ◽  
Shahinoor Begum ◽  
Jeremy D Hearn ◽  
Richard O Hynes
Keyword(s):  
Tumor Growth ◽  
Tissue Transglutaminase ◽  
Melanoma Tumor ◽  
Tumor Growth And Metastasis

scholarly journals Systemic Platelet-activating Factor Receptor Activation Augments Experimental Lung Tumor Growth and Metastasis

2014 ◽  
Vol 7 ◽  
pp. CGM.S14501 ◽  
Author(s):  
Patrick C. Hackler ◽  
Sarah Reuss ◽  
Raymond L. Konger ◽  
Jeffrey B. Travers ◽  
Ravi P. Sahu
Keyword(s):  
Lung Cancer ◽  
Tumor Growth ◽  
Cancer Progression ◽  
Lung Tumor ◽  
Platelet Activating Factor ◽  
Receptor Activation ◽  
Dependent Manner ◽  
Melanoma Tumor ◽  
Tumor Growth And Metastasis ◽  
The Impact

Pro-oxidative stressors including cigarette smoke (CS) generate novel lipids with platelet-activated factor-receptor (PAF-R) agonistic activity mediate systemic immunosuppression, one of the most recognized events in promoting carcinogenesis. Our previous studies have established that these oxidized-PAF-R-agonists augment murine B16F10 melanoma tumor growth in a PAF-R-dependent manner because of its effects on host immunity. As CS generates PAF-R agonists, the current studies sought to determine the impact of PAF-R agonists on lung cancer growth and metastasis. Using the murine Lewis Lung Carcinoma (LLC1) model, we demonstrate that treatment of C57BL/6 mice with a PAF-R agonist augments tumor growth and lung metastasis in a PAF-R-dependent manner as these findings were not seen in PAF-R-deficient mice. Importantly, this effect was because of host rather than tumor cells PAF-R dependent as LLC1 cells do not express functional PAF-R. These findings indicate that experimental lung cancer progression can be modulated by the PAF system.

scholarly journals Genetic Ablation of Cav1 Differentially Affects Melanoma Tumor Growth and Metastasis in Mice: Role of Cav1 in Shh Heterotypic Signaling and Transendothelial Migration

2012 ◽  
Vol 72 (9) ◽  
pp. 2262-2274 ◽  
Author(s):  
Franco Capozza ◽  
Casey Trimmer ◽  
Remedios Castello-Cros ◽  
Sanjay Katiyar ◽  
Diana Whitaker-Menezes ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Transendothelial Migration ◽  
Melanoma Tumor ◽  
Genetic Ablation ◽  
Tumor Growth And Metastasis

Abstract 1460: AKAP12 regulates melanoma tumor growth and metastasis

2011 ◽  
Author(s):  
Elizabeth C. Finger ◽  
Alice Banh ◽  
Erinn B. Rankin ◽  
Marta Vilalta ◽  
Adam J. Krieg ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Melanoma Tumor ◽  
Tumor Growth And Metastasis

scholarly journals V3 versican isoform expression has a dual role in human melanoma tumor growth and metastasis

2006 ◽  
Vol 86 (9) ◽  
pp. 889-901 ◽  
Author(s):  
Laia Miquel-Serra ◽  
Montserrat Serra ◽  
Daniel Hernández ◽  
Clelia Domenzain ◽  
María José Docampo ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Human Melanoma ◽  
Dual Role ◽  
Melanoma Tumor ◽  
Isoform Expression ◽  
Tumor Growth And Metastasis

scholarly journals NFAT1 Directly Regulates IL8 and MMP3 to Promote Melanoma Tumor Growth and Metastasis

2016 ◽  
Vol 76 (11) ◽  
pp. 3145-3155 ◽  
Author(s):  
Einav Shoshan ◽  
Russell R. Braeuer ◽  
Takafumi Kamiya ◽  
Aaron K. Mobley ◽  
Li Huang ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Melanoma Tumor ◽  
Tumor Growth And Metastasis
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